Electrochemistry of Purine Derivatives 1: Direct Determination for the Antiviral Drug 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine by Anodic Differential Pulse Voltammetry

Visor, Gary C.; Jackson, Stuart E.; Kenley, Richard A.; Lee, G.C.

doi:10.1002/jps.2600741012

Cited by 13 publications

(1 citation statement)

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“…They may also be of value under conditions caused by herpes, such as chickenpox and shingles. These drugs are not curative, but may reduce the pain of a herpes outbreak and shorten the period of viral shedding [1][2][3]. These compounds are converted rapidly and extensively into acyclovir, the active antiviral component of valacyclovir, and L-valine, an essential amino acid, probably in the liver and the intestine by hydrolysis, after oral administration.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic and Analytic Properties of New Copper(II) Complex of Antiviral Drug Valacyclovir

Gölcü

Dolaz

Demirelli

et al. 2006

Transition Met Chem

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The complexation processes between Cu II and the antiviral drug, valacyclovir hydrochloride (H 2 L), were studied under different reaction conditions, using UV-Vis, IR and mass spectra, magnetochemical, thermogravimetric, atomic absorption, conductivity, and elemental analysis data. Using the Job method, the compositions of these complexes were determined. Under the ligand (H 2 L) excess (M:L = 1:1-1:10). In aqueous solutions, a binuclear violet complex Cu 2 (HL) 2 L(H 2 O) 4 is formed, with an octahedral structure. Under comparable amounts of the reagents, in MeOH solutions, a green mononuclear complex Cu(H 2 L)Cl 2 is formed. Protonation constants of the H 2 L, and stability constants of its Cu 2+ complexes, were determined by potentiometric titration in H 2 O media at 25±0.02°C under a N 2 atmosphere and ionic strength of 0.1 M NaCl. It has been observed that H 2 L has three protonation constants. The divalent metal ion Cu 2+ forms stable 2:1 and 2:2 complexes with H 2 L. The antimicrobial activity studies of the valacyclovir and it's complexes have been studied against some gram positive species:

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Section: Introductionmentioning

confidence: 99%