Electrochemotherapy in Veterinary Oncology

Tozon, Nataša; Milevoj, Nina; Impellizeri, Joseph A.

doi:10.1007/978-3-030-80668-2_3

Cited by 2 publications

(6 citation statements)

References 99 publications

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“…Treating the back of a Doberman, where very sharp and rigid needles are needed, is different from treating the sensitive nose of the cat. Veterinary ECT is more challenging if we consider the variety of species that can be treated, i.e., cats [37,39,62] , dogs [63,64] , horses [65,66] , and even wild animals [67,68] , and, ideally, an equal variety of electrodes should be available. The inconveniences of using the same electrodes for every patient are often accepted, but it may lead to poorer results for the patients.…”

Section: Discussionmentioning

confidence: 99%

“…ECT may be used independently or in combination with surgery, especially when the surgery cannot provide clean margins. ECT may be used as a neoadjuvant, adjuvant, or concomitant therapy [37][38][39][40] . Some authors have reported an objective response rate of 97.3% when treating feline patients with nasal planum cSCC with minimum side effects [41] .…”

Section: Electrochemotherapymentioning

confidence: 99%

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Electrochemotherapy using thin-needle electrode improves recovery in feline nasal planum squamous cell carcinoma - a translational model

Tellado¹,

Michinski²,

Impellizeri³

et al. 2022

Cancer Drug Resist

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Aim: Cutaneous squamous cell carcinoma (cSCC) is a common disease in patients exposed to UV-light and human papillomavirus. Electrochemotherapy, a well-established treatment modality with minimum side effects in human and veterinary medicine, circumvents chemoresistance to bleomycin by the use of electric fields. However, patients are sensitive to the trauma produced by the insertion of the needles that lengthen recovery times, particularly cats with nasal planum cSCC. To address this matter, we developed thin-needles electrodes. Methods: Thin-needles electrodes developed using computer simulations and plant tissue models were compared to standard electrodes. A prospective non-randomized study recruiting 52 feline patients with nasal planum cSCC was performed. Local response, anorexia, and overall survival were evaluated. Results: Computer simulations and plant model experiments showed satisfactory results with both electrodes. The patients treated with the thin-needle electrode obtained similar local response rates compared to the standard group, OR 97.3% vs. 80%, respectively (P < 0.067). Most patients in the thin-needle group resumed eating in less than 48 h, as the anorexia was significantly lower (P < 0.0001). Using the standard electrode, most patients took 3 to 5 days to resume normal feeding. The electric current circulating in the standard electrode was 44% higher, contributing to a longer duration of anorexia due to tissue damage. The overall survival in both groups was similar. Conclusion: Electrochemotherapy using thin-needle electrodes provides equivalent local response rates and overall survival compared with standard electrodes but significantly reduced return to appetite after the treatment. These results may be useful in the development of new electrodes for human patients.

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Section: Discussionmentioning

confidence: 99%

Section: Electrochemotherapymentioning

confidence: 99%

Electrochemotherapy using thin-needle electrode improves recovery in feline nasal planum squamous cell carcinoma - a translational model

Tellado¹,

Michinski²,

Impellizeri³

et al. 2022

Cancer Drug Resist

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“…Cutaneous or subcutaneous tumors (primary or metastatic) of any histology, which cannot be satisfactorily treated with their respective first-line treatments ( 26 , 31 ).…”

Section: Materials Equipment and Patientsmentioning

confidence: 99%

“…Primary or metastatic tumors affecting the quality of life due to bleeding, ulceration, or pain ( 26 ).…”

Section: Materials Equipment and Patientsmentioning

confidence: 99%

“…It is also important to recall that the therapy can be combined with other treatment modalities increasing their effectiveness, for example in combination with debulking surgery, chemo, or radiotherapy ( 25 ). Finally, ECT can be applied when no other treatment options are available, still with good results, making ECT a very attractive tool for the veterinary oncologist ( 26 ).…”

Section: Introductionmentioning

confidence: 99%

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Veterinary Guidelines for Electrochemotherapy of Superficial Tumors

Tellado¹,

Mir

Maglietti

2022

Front. Vet. Sci.

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Electrochemotherapy (ECT) consists in the application of electric pulses to increase chemotherapeutic drug intake (bleomycin, cisplatin, or calcium) into the tumor cells. It has become a very valuable treatment option in veterinary oncology. It is an effective and safe treatment modality, which is not only beneficial as a palliative treatment, but also for a curative approach. Performing the treatment adequately will ensure the best results possible, in the minimum number of sessions, and reduce complications. Usually, only one session is enough to achieve excellent results, but the treatment can be repeated. Several sessions can be necessary in the case of incompletely treated or very extended lesions, as well as in the occurrence of new lesions. ECT is effective for superficial or oral tumors of any histology that are accessible to the electrodes. Intravenous bleomycin is the preferred drug and route of administration, leaving other ways of administration and drugs for selected cases. The guidelines presented here are destined to veterinarians who want to develop their understanding of the basis of ECT and wish to perform it adequately and effectively. In this paper, we also discuss common problems and how to solve them, and we include practical tips to improve the treatment results based on common questions and mistakes of beginner users.

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Electrochemotherapy in Veterinary Oncology

Cited by 2 publications

References 99 publications

Electrochemotherapy using thin-needle electrode improves recovery in feline nasal planum squamous cell carcinoma - a translational model

Electrochemotherapy using thin-needle electrode improves recovery in feline nasal planum squamous cell carcinoma - a translational model

Veterinary Guidelines for Electrochemotherapy of Superficial Tumors

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