Electroclinical and imaging findings in ulegyria and epilepsy: a study on 25 patients

Kuchukhidze, Giorgi; Unterberger, Iris; Dobesberger, Judith; Embacher, Norbert; Walser, Gerald; Haberlandt, Edda; Gotwald, Thaddaeus; Maier, Hans; Ortler, Martin; Felber, S.; Bauer, Gerhard; Trinka, Eugen

doi:10.1136/jnnp.2007.118216

Cited by 30 publications

(36 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Surgical treatment for posterior cortex epilepsy due to tumors and cortical dysplasia has been reported (Aykut‐Bingol et al, 1998; Boesebeck et al, 2002). Ulegyria is usually bilateral, and coexistence with hippocampal sclerosis has been reported (Kuchukhidze et al, 2008). However, the surgical indication and strategy for posterior cortex epilepsy due to ulegyria has not been reported.…”

mentioning

confidence: 99%

Posterior cortex epilepsy secondary to ulegyria: Is it a surgically remediable syndrome?

et al. 2008

View full text Add to dashboard Cite

Summary Purpose: To examine whether surgery is indicated for posterior cortex epilepsy secondary to ulegyria. Patients and methods: Ten patients who underwent surgery for posterior cortex epilepsy with ulegyria and were followed for more than 2 years were included. All patients underwent comprehensive presurgical evaluations. Five patients underwent intracranial electroencephalography (EEG) studies. The posterior cortex including the magnetic resonance imaging (MRI) lesion was resected in all patients. Postoperative follow‐up period was 2–12 (mean 6) years. Results: Nine patients had a history of perinatal distress including asphyxia and prolonged labor. Age at seizure onset was 5–11 years, except one patient. Three patients had visual field defects preoperatively. Ulegyria was unilateral in four patients and bilateral but unilateral‐predominant in six patients. In most of the cases, the lesions were in the posterior cerebral artery area or the watershed area between middle cerebral and posterior cerebral arteries. In four of five patients who underwent intracranial EEG, seizure onset zones extended outside the lesions. Postoperative seizure outcome was Engel's class I in seven cases, and class III in three cases. Three of four patients whose seizure onset zones were not completely resected achieved class I outcome. Four of six patients with bilateral lesions achieved class I outcome. Conclusion: Ulegyria due to perinatal distress is considered to be a major cause of posterior cortex epilepsy. Long‐term postoperative seizure outcome is favorable. Resection of MRI lesion is important for seizure relief. Bilateral lesions should not be excluded from surgical indication. The usefulness of intracranial EEG may be limited.

show abstract

mentioning

confidence: 99%

Posterior cortex epilepsy secondary to ulegyria: Is it a surgically remediable syndrome?

et al. 2008

View full text Add to dashboard Cite

show abstract

“…The recognition that the epilepsy and visiual loss had a common substrate was not appreciated until adulthood. In previous series of posterioronset epilepsy secondary to ulegyria, ictal semiology, characteristic of temporal, frontal, and parietal cortical regions, has been demonstrated (Kuchukhidze et al, 2008). Watershed zones between the major cerebral arteries in the term newborn are vulnerable to reduced perfusion.…”

Section: Discussionmentioning

confidence: 95%

“…Interestingly, ulegyria is thought to most commonly involve the occipital lobes (Kuchukhidze et al, 2008). The detection of ulegria on brain imaging provided the proof that each patient's visual loss and drug-resistant epilepsy had a common tissue substrate and cause.…”

Section: Discussionmentioning

confidence: 99%

“…This results in tissue at the base of gyri being more susceptible to hypoxic injury. Despite ulegyria being first described in 1899, it is rarely reported in the literature (Kuchukhidze et al, 2008). frontoparietal, occipital, and perisylvian areas, are particularly vulnerable (Kuchukhidze et al, 2008).…”

mentioning

confidence: 99%

“…Watershed zones of the major cerebral arteries, i.e. A retrospective review at a tertiary referral centre reported a frequency of 0.5% amongst attending epilepsy patients (Kuchukhidze et al, 2008). Despite ulegyria being first described in 1899, it is rarely reported in the literature (Kuchukhidze et al, 2008).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Occipital ulegyria causing epilepsy and visual impairment: an easily overlooked epilepsy syndrome

O’Connor

Costello

2017

Epileptic Disorders

View full text Add to dashboard Cite

Ulegyria refers to scarring of the cerebral cortex usually arising from perinatal ischaemia. The scarring has a specific configuration in which small atrophic circumvolutions at the bottom of a sulcus underlie an intact spared gyral apex. This disconnection of overlying cortex may allow an “epileptogenic” island of cortex to generate seizures. Ulegyria is often associated with epilepsy and developmental delay, however, the syndromic association of visual impairment with epilepsy due to occipital ulegyria may not be recognised as a specific entity. Here, we report a series of five patients with occipital ulegyria who presented with widely variable seizure semiology and an array of visual deficits. In some patients, the link between the epilepsy and the visual impairment was not appreciated until they attended an epilepsy clinic.

show abstract

Diseases of the Central Nervous System

Shimosegawa¹,

Shigemoto²,

Sato³

et al. 2023

Radiology‐Nuclear Medicine Diagnostic Imaging

View full text Add to dashboard Cite

Electroclinical and imaging findings in ulegyria and epilepsy: a study on 25 patients

Abstract: Patients with ulegyria often have a history of perinatal asphyxia and present with pharmacoresistant seizures. Their presurgical assessment is complicated because of frequent dual pathology (hippocampal sclerosis) and bilateral lesions.

Cited by 30 publications

References 17 publications

Posterior cortex epilepsy secondary to ulegyria: Is it a surgically remediable syndrome?

Posterior cortex epilepsy secondary to ulegyria: Is it a surgically remediable syndrome?

Occipital ulegyria causing epilepsy and visual impairment: an easily overlooked epilepsy syndrome

Diseases of the Central Nervous System

Contact Info

Product

Resources

About