Electroconductive natural polymer-based hydrogels

Shi, Zhijun; Gao, Xing; Ullah, Muhammad Wajid; Li, Sixiang; Wang, Qun; Yang, Guang

doi:10.1016/j.biomaterials.2016.09.020

Cited by 326 publications

(165 citation statements)

References 185 publications

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“…[ 17 ] In addition, Scaffold's wettability is a key factor to be considered in the fabrication of scaffold as it determines its hydrophobicity or philicity that could affect its biological function. [ 52 ] The results for water contact angle measurement of precoated and postcoated scaffold were shown in Figure 3e,f. The water contact angle of the precoated scaffold is 126.3°, and for the postcoated scaffold is 68.2°.…”

Section: Resultsmentioning

confidence: 99%

Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes

Liu

Zhang

et al. 2020

Macro Materials & Eng

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Skin injuries are an urgent health issue, which raises a great concern in the clinic. Although numerous strategies have been proposed to fabricate skin substitutes for treatment of wounds over the past several decades, fabricating an ideal skin substitute to replace the damaged one can still be a problem. In this study, a novel biomimetic 3D composite skin scaffold is fabricated by combining electrohydrodynamic (EHD) jetting, electrospinning, and coating techniques. Here, the first polycaprolactone (PCL) porous structure is produced by the EHD jetting. Next, the second polylactic acid (PLA) membrane consisted of nanoscale fibers is prepared on the PCL porous structure via the electrospinning. The PCL porous structure and PLA fibers membrane can mimic the dermis and epidermis layer, respectively. Furthermore, gelatin is used as coating solution to enhance the biocompatibility of the scaffold. The structure and morphology of the fabricated scaffolds are analyzed, and the mechanical properties are investigated as well. Moreover, the in vitro and in vivo experiments demonstrate the biocompatibility of the materials and the fabrication process. In conclusion, these results demonstrate that the composite scaffold is effective and holds great potential for skin regeneration in the clinic.

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Section: Resultsmentioning

confidence: 99%

Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes

Liu

Zhang

et al. 2020

Macro Materials & Eng

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“…Natural hydrogels are made from natural polymers, including polysaccharides (e.g., hyaluronic acid [HA], alginate, chitosan, and cellulose), proteins (collagen, gelatine), and DNA. These polymers can be obtained from various natural sources (e.g., mammals, insects, shellfish exoskeletons, bacteria, plants, algae) . The main advantage of natural polymers, in addition to their natural availability, is the increased physiological resemblance with the extracellular matrix in vivo .…”

Section: Sterilization Of Hydrogel‐based Medical Devicesmentioning

confidence: 99%

Sterilization of hydrogels for biomedical applications: A review

et al. 2017

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Despite the beneficial properties and outstanding potential of hydrogels for biomedical applications, several unmet challenges must be overcome, especially regarding to their known sensitivity to conventional sterilization methods. It is crucial for any biomaterial to withstand an efficient sterilization to obtain approval from regulatory organizations and to safely proceed to clinical trials. Sterility assurance minimizes the incidence of medical device-related infections, which still constitute a major concern in health care. In this review, we provide a detailed and comprehensive description of the published work from the past decade regarding the effects of sterilization on different types of hydrogels for biomedical applications. Advances in hydrogel production methods with simultaneous sterilization are also reported. Terminal sterilization methods can induce negative or positive effects on several material properties (e.g., aspect, size, color, chemical structure, mechanical integrity, and biocompatibility). Due to the complexity of factors involved (e.g., material properties, drug stability, sterilization conditions, and parameters), it is important to note the virtual impossibility of predicting the outcome of sterilization methods to determine a set of universal rules. Each system requires case-by-case testing to select the most suitable, effective method that allows for the main properties to remain unaltered. The impact of sterilization methods on the intrinsic properties of these systems is understudied, and further research is needed. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2472-2492, 2018.

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“…Therefore, the ordered BC scaffolds can support the alignment of cells out growth, and furthermore, this method has the potential to fabricate large BC sheets with multilevel, microstructured surfaces with complex, variable geometries at micrometer and even in nanometer range. Such multileveled microstructures could be modified with bioactive or functional molecules to several other advanced applications, such as fabrication of ordered conductive scaffolds to promote skin or neural regeneration under electrical stimulation [136]. In another study, we developed a strategy to rapidly fabricate multilayered tubular structures by employing the shape-memory property of BC membranes.…”

Section: Microbial Cell Factories: Manufacturing Functional Metabolitesmentioning

confidence: 99%

Fabrication of nanocomposites and hybrid materials using microbial biotemplates

Shi

Ullah

et al. 2017

Adv Compos Hybrid Mater

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Microbes are important part of life that vary in sizes and shapes, diverse surface chemistry and biology, and porous nature of their cell walls. Besides their importance in industrial processes such as fermentation, these serve as biotemplates and provide a biomimetic approach for fabrication of multifarious complex constructs with predefined features, ordered composites and hybrid nanomaterials, microdevices, and micro/nanorobots through various strategies. The template or building blocks for such approaches can be bacterial, algal, and fungal cells or virus particles. Here, we have summarized recent advancements in biofabrication based on live microbes. Using engineering approaches and suitable methods, live microbes can be manipulated as functional Bmicro/nanodevices and -robots^to further perform biological functions such as replication, distribution, motility, formation of colonies, and secretion of metabolites at will. Biofabrication based on microbes provides effective methods to control and manipulate microbes as functional live building blocks to create micro/nanodevices and -robots for biomedical and energy applications.

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Electroconductive natural polymer-based hydrogels

Cited by 326 publications

References 185 publications

Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes

Development and Evaluation of Biomimetic 3D Coated Composite Scaffold for Application as Skin Substitutes

Sterilization of hydrogels for biomedical applications: A review

Fabrication of nanocomposites and hybrid materials using microbial biotemplates

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