Electroconvulsive stimulations prevent chronic stress-induced increases in L-type calcium channel mRNAs in the hippocampus and basolateral amygdala

Maigaard, Katrine; Hageman, Ida; Jørgensen, Anders; Jørgensen, Martin Balslev; Wörtwein, Gitta

doi:10.1016/j.neulet.2012.03.043

Cited by 25 publications

(11 citation statements)

References 23 publications

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“…In this study, several components of the Wnt, Hippo and Fak-Mapk pathways were found to be up-or down-regulated during different phases of DO by microarray. The results revealed that the Wnt pathway was Previous studies demonstrated that mechanical stimulation could induce changes in molecular function, demonstrated by the up-or down-regulation of transcription factors, 25,26 increased mRNA synthesis, 27 and cause changes in gene expression. 28,29 Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that associates with integrins at focal adhesion in the Integrin-Fak pathway.…”

Section: Altered Expression Of Bone Formation-related Molecular Patmentioning

confidence: 85%

“…Previous studies demonstrated that mechanical stimulation could induce changes in molecular function, demonstrated by the up‐ or down‐regulation of transcription factors, increased mRNA synthesis, and cause changes in gene expression . Focal adhesion kinase (FAK) is a non‐receptor tyrosine kinase that associates with integrins at focal adhesion in the Integrin‐Fak pathway .…”

Section: Discussionmentioning

confidence: 99%

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Fak‐Mapk, Hippo and Wnt signalling pathway expression and regulation in distraction osteogenesis

Song

Liu

et al. 2018

Cell Proliferation

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Section: Altered Expression Of Bone Formation-related Molecular Patmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Fak‐Mapk, Hippo and Wnt signalling pathway expression and regulation in distraction osteogenesis

Song

Liu

et al. 2018

Cell Proliferation

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“…Of note, animal models suggest specificity of the neuroplastic effects, with neurogenesis occurring in the dentate gyrus of the hippocampus (14) and attenuated dendritic arborization in the basolateral complex of the amygdala (56). Furthermore, the expression of voltagegated calcium channels in the basolateral complex and the dentate gyrus are selectively downregulated by ECS (57), which is likely to improve neuronal survival (58). As such, studies of global volumetric changes of these brain areas may not be sensitive to ECT outcome, which is appreciated by recent studies further dividing these brain areas into their respective subfields.…”

Section: Discussionmentioning

confidence: 99%

Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

Ousdal

Árgyelán

Narr

et al. 2020

Biological Psychiatry

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BACKGROUND: Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray matter, white matter, and ventricle volumes in patients with major depressive disorder as well as predictors of ECT-related clinical response. METHODS: Longitudinal magnetic resonance imaging and clinical data from the Global ECT-MRI Research Collaboration (GEMRIC) were used to investigate changes in white matter, gray matter, and ventricle volumes before and after ECT in 328 patients experiencing a major depressive episode. In addition, 95 nondepressed control subjects were scanned twice. We performed a mega-analysis of single subject data from 14 independent GEMRIC sites. RESULTS: Volumetric increases occurred in 79 of 84 gray matter regions of interest. In total, the cortical volume increased by mean 6 SD of 1.04 6 1.03% (Cohen's d = 1.01, p , .001) and the subcortical gray matter volume increased by 1.47 6 1.05% (d = 1.40, p , .001) in patients. The subcortical gray matter increase was negatively associated with total ventricle volume (Spearman's rank correlation r = 2.44, p , .001), while total white matter volume remained unchanged (d = 20.05, p = .41). The changes were modulated by number of ECTs and mode of electrode placements. However, the gray matter volumetric enlargements were not associated with clinical outcome. CONCLUSIONS: The findings suggest that ECT induces gray matter volumetric increases that are broadly distributed. However, gross volumetric increases of specific anatomically defined regions may not serve as feasible biomarkers of clinical response.

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“…The current findings indicate that cells born up to a week after a 1‐day stress continue to show decreased survival. L‐type calcium channels containing the Ca V 1.2 subunit, which are upregulated in the hippocampus following SPS and chronic stress and have been implicated in PTSD (Ji et al, ; Krzyzewska et al, ; Maigaard, Hageman, Jørgensen, Jørgensen, & Wörtwein, ), may be an important part of the mechanism regulating the survival of new neurons following SPS. A recent study found that cells born at the end of chronic stress period showed increased survival relative to cells born in unstressed rats (De Miguel, Haditsch, Palmer, Azpiroz, & Sapolsky, ), suggesting that the removal of stress may have a positive effect on survival of a cohort of neurons maturing during the poststress recovery period.…”

Section: Discussionmentioning

confidence: 99%

New neurons restore structural and behavioral abnormalities in a rat model of PTSD

et al. 2019

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Post-traumatic stress disorder (PTSD) has been associated with anxiety, memory impairments, enhanced fear, and hippocampal volume loss, although the relationship between these changes remain unknown. Single-prolonged stress (SPS) is a model for PTSD combining three forms of stress (restraint, swim, and anesthesia) in a single session that results in prolonged behavioral effects. Using pharmacogenetic ablation of adult neurogenesis in rats, we investigated the role of new neurons in the hippocampus in the long-lasting structural and behavioral effects of SPS. Two weeks after SPS, stressed rats displayed increased anxiety-like behavior and decreased preference for objects in novel locations regardless of the presence or absence of new neurons. Chronic stress produced by daily restraint for 2 or 6 hours produced similar behavioral effects that were also independent of ongoing neurogenesis. At a longer recovery time point, one month after SPS, rats with intact neurogenesis had normalized, showing control levels of anxiety-like behavior. However, GFAP-TK rats, which lacked new neurons, continued to show elevated anxiety-like behavior and enhanced serum corticosterone response to anxiogenic experience. Volume loss in ventral CA1 paralleled increases in anxiety-like behavior, occurring in all rats exposed to SPS at the early time point and only rats lacking adult neurogenesis at the later time point. In chronic stress experiments, volume loss occurred broadly throughout the dentate gyrus and CA1 after 6-hour daily stress but was not apparent in any hippocampal subregion after 2-hr daily stress. No effect of SPS was seen on cell proliferation in the dentate gyrus, but the survival of young neurons born a week after stress was decreased. Together, these data suggest that new neurons are functionally important for recovery of normal behavior and hippocampal structure following a strong acute stress and point to the ventral CA1 region as a potential key mediator of stress-induced anxiety-like behavior.

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Electroconvulsive stimulations prevent chronic stress-induced increases in L-type calcium channel mRNAs in the hippocampus and basolateral amygdala

Cited by 25 publications

References 23 publications

Fak‐Mapk, Hippo and Wnt signalling pathway expression and regulation in distraction osteogenesis

Fak‐Mapk, Hippo and Wnt signalling pathway expression and regulation in distraction osteogenesis

Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

New neurons restore structural and behavioral abnormalities in a rat model of PTSD

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