Electroconvulsive therapy for the physical signs of Parkinson's disease without depressive disorder.

Pridmore, Saxby; Yeo, Philip; Pasha, Mohamed Iqbal

doi:10.1136/jnnp.58.5.641-a

Cited by 31 publications

(22 citation statements)

References 5 publications

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“…74,75 Indeed, ECT has been tried as a treatment for motor symptoms in PD patients without depression, with apparent positive results, lasting from several weeks to months. [76][77][78] Looking at the limited number of studies, and their largely negative results, it is not surprising that 2 systematic reviews have concluded that there is insufficient evidence for the efficacy and safety of SSRIs and tricyclic antidepressants (TCAs) in the treatment of depression in PD, with the exception of a possible efficacy of nortriptyline. 79,80 The most important consequence of the high placeboresponse in the aforementioned double-blind studies is that studies that have not followed a placebo-controlled design will never provide evidence of a superior efficacy of antidepressant treatment.…”

Section: Treatmentmentioning

confidence: 99%

Depression in Parkinson’s Disease: Conceptual Issues and Clinical Challenges

Leentjens

2004

J Geriatr Psychiatry Neurol

128

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Background: Depression frequently accompanies Parkinson’s disease (PD) and may have a negative impact on activities of daily living, cognitive performance, and quality of life. Because of the symptom overlap between the 2 disorders, it may be difficult to recognize depression in PD. Moreover, the partially shared pathophysiology may make it difficult to treat depressive symptoms without influencing motor or cognitive function. Objective: To review the current knowledge of the epidemiology, etiology, pathophysiology, and treatment of depression in patients with Parkinson’s disease. Method: Discussion of recent studies and relevant literature. Conclusion: Not only conceptually but also in terms of etiology, pathophysiology, and treatment, the relationship between PD and depression remains a challenge. There are still many questions to be answered. In the therapeutic domain, large, placebo-controlled trials are necessary to evaluate the efficacy of antidepressant treatment and allow the development of evidence-based guidelines. (J Geriatr Psychiatry Neurol 2004; 17:120-126)

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Section: Treatmentmentioning

confidence: 99%

Depression in Parkinson’s Disease: Conceptual Issues and Clinical Challenges

Leentjens

2004

J Geriatr Psychiatry Neurol

128

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“…During this review period, there have been 21 new reports of patients with PD undergoing ECT, [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]26,27,29,30 and four additional reports describing ECT and parkinsonian syndromes (totaling 25 reports). During this review period, there have been 21 new reports of patients with PD undergoing ECT, [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]26,27,29,30 and four additional reports describing ECT and parkinsonian syndromes (totaling 25 reports).…”

Section: Parkinson's Disease and Parkinsonian Syndromesmentioning

confidence: 99%

“…12,26 One of these 12 focused on the safety of ECT with organic brain disorders and made no comment on the outcome of movement disorders. 14,[19][20][21][22]30 One 14 focused on the incidence of delirium in PD patients receiving ECT, with no comment on the movement disorder. There were four prospective, open trials during this review period.…”

Section: Parkinson's Disease and Parkinsonian Syndromesmentioning

confidence: 99%

Electroconvulsive Therapy in Movement Disorders: An Update

Kennedy

Mittal²,

O'Jile³

2003

JNP

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Electroconvulsive therapy (ECT) is a well-recognized treatment for psychiatric illness, primarily depressive disorders. Its use in patients with neurological illnesses is steadily increasing. Older reviews indicate that ECT may also benefit Parkinson's disease and similar movement disorders independent of its effects on comorbid psychiatric disorders. In this updated review, recent literature regarding ECT and movement disorders is summarized from 1990 to 2000. Considerable evidence indicates that ECT improves motor symptoms of Parkinson's disease in patients with and without mood disorders. A few case reports, ranging from one to six patients per disorder, suggest that ECT may ameliorate the motor symptoms of other movement disorders. ECT affects a variety of neurotransmitters that play a role in these diseases. Limitations of current reports are reviewed, and recommendations for further investigation are made.

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“…6,14,[24][25][26][27][28][29] Several mechanisms of action have been proposed for ECT in IPD. The improvement in motor symptoms was caused by resolved depression, with reduced psychomotor retardation.…”

Section: Discussionmentioning

confidence: 99%

Electroconvulsive Therapy in Drug-Induced Psychiatric States and Neuroleptic Malignant Syndrome

Özer¹,

Meral²,

Aydın³

et al. 2005

The Journal of ECT

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In the late-stage idiopathic Parkinson's disease (IDP), comorbid conditions such as depression and drug-induced psychosis may be observed. A patient with Parkinson disease, major depression, and paranoid psychosis who developed neuroleptic malignant syndrome (NMS) as the result of the sudden termination of high-dose (1200 mg/d) levodopa treatment is presented in this report. Because the patient did not respond to other treatment modalities, electroconvulsive therapy (ECT) was applied, and a rapid improvement was observed both in the patient's NMS and also in Parkinson's and psychiatric symptoms, with no additional side effects other than transient post-ictal confusions. The application of ECT allowed the patient to remain stable for a 5-year period with a quite low dose of levodopa (300 mg/d). Later, the patient had two episodes of depressive and psychotic symptoms, which were again successfully treated with the ECT. We suggest that ECT might be an effective and life-saving therapy in patients with severe, drug-resistant NMS.

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Electroconvulsive therapy for the physical signs of Parkinson's disease without depressive disorder.

Cited by 31 publications

References 5 publications

Depression in Parkinson’s Disease: Conceptual Issues and Clinical Challenges

Depression in Parkinson’s Disease: Conceptual Issues and Clinical Challenges

Electroconvulsive Therapy in Movement Disorders: An Update

Electroconvulsive Therapy in Drug-Induced Psychiatric States and Neuroleptic Malignant Syndrome

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