Electrocorticographic and neurochemical findings after local cortical valproate application in patients with pharmacoresistant focal epilepsy

Altenmüller, Dirk‐Matthias; Hebel, Jonas M.; Deniz, Cagan; Volz, Silvanie; Zentner, Josef; Feuerstein, Thomas J.; Möser, Andreas

doi:10.1111/epi.16523

Cited by 4 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glutamate, the predominant excitatory transmitter, has been reported to be reduced by VPA. 48 In HT22 cells, administration of 1 mM VPA significantly prevented glutamate‐induced neuron injury by inhibiting ROS production, calcium content, and LDH release. This result is in line with those of the previous studies in which 1 mM VPA significantly ameliorated radiation‐ and hemin‐induced neuron injury.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Overexpression of Homer1b/c induces valproic acid resistance in epilepsy

Wang

et al. 2022

CNS Neurosci Ther

View full text Add to dashboard Cite

Aims: Resistance to valproic acid (VPA) is a major challenge for epilepsy treatment.We aimed to explore the mechanism underlying this resistance.Methods: Pentylenetetrazol-induced chronic epileptic rats were administered VPA (250 mg/Kg) for 14 days; rats with controlled seizure stages (seizure score 14th-before ≤0) and latent time (latent time 14th-before ≥0) were considered VPA-responsive, while the others were considered nonresponsive. Differentially expressed genes (DEGs) between the VPA-responsive and nonresponsive rat hippocampus transcriptomes were identified, and their functions were evaluated. The roles of postsynaptic density (PSD) and Homer1 were also determined. Furthermore, a subtype of Homer1 (Homer1b/c) was overexpressed or silenced in HT22 cells to determine its effect on VPA efficacy.Moreover, the membrane levels of mGluR1/5 directly bound to Homer1b/c were assessed.Results: Overall, 264 DEGs commonly enriched in the PSD between VPA-responsive and nonresponsive rats. Among them, Homer1 was more highly expressed in the hippocampus of nonresponses compared to that of responses. Overexpression of Homer1b/c interrupted VPA efficacy by increasing reactive oxygen species production, lactate dehydrogenase release, and calcium content. Furthermore, it induced the overexpression of mGluR1 and mGluR5. Conclusion:Overexpression of Homer1b/c influenced VPA efficacy, revealing it could be a target to improve the efficacy of this treatment.

show abstract

Section: Discussionmentioning

confidence: 94%

“…Glutamate, the predominant excitatory transmitter, has been reported to be reduced by VPA 48 . In HT22 cells, administration of 1 mM VPA significantly prevented glutamate‐induced neuron injury by inhibiting ROS production, calcium content, and LDH release.…”

Section: Discussionmentioning

confidence: 97%

Overexpression of Homer1b/c induces valproic acid resistance in epilepsy

Wang

et al. 2022

CNS Neurosci Ther

View full text Add to dashboard Cite

show abstract

“…Electroencephalogram plays an important role in the diagnosis, treatment, and prognosis of epilepsy ( 40 – 42 ). Electroencephalogram signals have non-linear structures in the time dimension.…”

Section: Discussionmentioning

confidence: 99%

“…Electroencephalogram plays an important role in the diagnosis, treatment, and prognosis of epilepsy (40)(41)(42).…”

Section: Eeg Complexity As a Biomarker For Epilepsymentioning

confidence: 99%

EEG-Driven Prediction Model of Oxcarbazepine Treatment Outcomes in Patients With Newly-Diagnosed Focal Epilepsy

et al. 2022

View full text Add to dashboard Cite

Objective: Antiseizure medicine (ASM) is the first choice for patients with epilepsy. The choice of ASM is determined by the type of epilepsy or epileptic syndrome, which may not be suitable for certain patients. This initial choice of a particular drug affects the long-term prognosis of patients, so it is critical to select the appropriate ASMs based on the individual characteristics of a patient at the early stage of the disease. The purpose of this study is to develop a personalized prediction model to predict the probability of achieving seizure control in patients with focal epilepsy, which will help in providing a more precise initial medication to patients.Methods: Based on response to oxcarbazepine (OXC), enrolled patients were divided into two groups: seizure-free (52 patients), not seizure-free (NSF) (22 patients). We created models to predict patients' response to OXC monotherapy by combining Electroencephalogram (EEG) complexities and 15 clinical features. The prediction models were gradient boosting decision tree-Kolmogorov complexity (GBDT-KC) and gradient boosting decision tree-Lempel-Ziv complexity (GBDT-LZC). We also constructed two additional prediction models, support vector machine-Kolmogorov complexity (SVM-KC) and SVM-LZC, and these two models were compared with the GBDT models. The performance of the models was evaluated by calculating the accuracy, precision, recall, F1-score, sensitivity, specificity, and area under the curve (AUC) of these models.Results: The mean accuracy, precision, recall, F1-score, sensitivity, specificity, AUC of GBDT-LZC model after five-fold cross-validation were 81%, 84%, 91%, 87%, 91%, 64%, 81%, respectively. The average accuracy, precision, recall, F1-score, sensitivity, specificity, AUC of GBDT-KC model with five-fold cross-validation were 82%, 84%, 92%, 88%, 83%, 92%, 83%, respectively. We used the rank of absolute weights to separately calculate the features that have the most significant impact on the classification of the two models.Conclusion: (1) The GBDT-KC model has the potential to be used in the clinic to predict seizure-free with OXC monotherapy. (2). Electroencephalogram complexity, especially Kolmogorov complexity (KC) may be a potential biomarker in predicting the treatment efficacy of OXC in newly diagnosed patients with focal epilepsy.

show abstract

“…Brain-machine interfaces with thousands of cell-recording electrode-channels implantable in the human cerebral cortex have already been developed (Musk & Neuralink, 2019), and molecular brain-machine interfaces (Ludvig, 2000;Ludvig et al, 2016) are supportively reexamined (Gernert & Feja, 2020) and tested with new approaches in clinical neurosurgical setting (Altenmüller at al, 2020). These achievements are still far from yielding knowledge on the guided complexity Figure 1.…”

Section: Neuroscience To Approach the Soul Of Multiverse At The Indiv...mentioning

confidence: 99%

A Cosmological Neuroscientific Approach to the Soul of Multiverse

Ludvig¹

2022

OJPP

View full text Add to dashboard Cite

Based on neuroscientific facts and cosmological considerations, the hypothesis is presented here that just as the guided complexity of matter and energy in the unique space-time of each human brain generates the host's Soul, the infinite complexity of the Multiverse, a more likely embodiment of the allness of existence than a single Universe, must also have a Soul. It is appreciated that this hypothesized Soul of Multiverse, imagined as majestically as obscurely in some ancient religious texts, is currently outside of the realm of science. Yet, this paper argues that the intellectual and technological advances of the 21 st century created favorable conditions for starting to address the nature of Soul across human and cosmic scales with the approach of cosmological neuroscience. This interdisciplinary field aims to examine the nervous system in the context of cosmic laws, including the laws that made life on Earth possible and let it evolve to generate the nervous system and its increasingly more sophisticated forms culminating into the appearance of human Soul and its noospheric expansion with purpose and potential to transcend. A human-specific prefrontal cortical supercircuitry termed Self-Ken, with domains Conscience, Mission, Will and Identity, is proposed for the neural center of the individual human Soul. The design of a globally applicable Noospheric Creativity Monitor is introduced to initiate the examination of Soul at its individual and global levels. Possible experimental astronomical and broadened cosmological studies are mentioned to evaluate the discussed hypothesis.

show abstract

Electrocorticographic and neurochemical findings after local cortical valproate application in patients with pharmacoresistant focal epilepsy

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 4 publications

References 18 publications

Overexpression of Homer1b/c induces valproic acid resistance in epilepsy

Overexpression of Homer1b/c induces valproic acid resistance in epilepsy

EEG-Driven Prediction Model of Oxcarbazepine Treatment Outcomes in Patients With Newly-Diagnosed Focal Epilepsy

A Cosmological Neuroscientific Approach to the Soul of Multiverse

Contact Info

Product

Resources

About