Electrode Model and Simulation of His- Bundle Pacing for Cardiac Resynchronization Therapy

Pascual, Domenic; Heinke, Matthias; Echle, Reinhard; Hörth, Johannes

doi:10.1515/cdbme-2020-3142

Cited by 1 publication

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 14 , 15 Voltage-dependent slowing of conduction has similarly been shown to occur in depressed ventricular conduction bundles. 16 This situation is comparable for the concealed accessory pathways, which are similarly considered to have a low safety factor of conduction. 14 …”

Section: Discussionmentioning

confidence: 96%

Evidence for concealed fasciculo-ventricular connections as revealed by His bundle pacing

et al. 2023

View full text Add to dashboard Cite

Background It is almost 100 years ago since Mahaim described the so-called paraspecific connections between the ventricular conduction axis and the crest of the muscular ventricular septum, believing such pathways to be ubiquitous. These pathways, however, have yet to be considered as potential pathways for septal activation during His bundle pacing. Materials So as to explore the hypothesis that specialised septal pathways might provide the substrate for septal activation during His bundle pacing, we compared the findings from 22 serially sectioned histological datasets and 34 different individuals undergoing His bundle pacing. Results We found histologically specialised pathways connecting the branching component of the atrioventricular conduction axis with the crest of the muscular ventricular septum in almost four-fifths of the histological datasets. In 32 of 34 patients undergoing His bundle pacing, the QRS complex closely resembled published images of known conduction through fasciculo-ventricular pathways. In only two patients was a delta wave not seen at any pacing voltages. Capture of these connections varied according to pacing voltage, a finding which correlated with the distance of the pathways from the site of penetration of the ventricular conduction axis. Ventricular activation times remained normal in the presence of the delta wave at higher pacing voltage but were prolonged at lower voltages. Conclusions Our histologic findings confirm fasciculo-ventricular connections, initially described by Mahaim as being paraspecific, are likely ubiquitous. Analysis of 12-lead electrocardiograms leads us to conclude that fasciculo-ventricular pathways, concealed during sinus rhythm, become manifest with His bundle pacing.

show abstract