Electrodeposited Fe and Fe–Au nanowires as MRI contrast agents

Shore, Daniel; Pailloux, Sylvie; Zhang, Jinjin; Gage, Thomas; Flannigan, David J.; Garwood, Michael; Pierre, Valérie C.; Stadler, Bethanie J. H.

doi:10.1039/c6cc06991f

Cited by 51 publications

(48 citation statements)

References 25 publications

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“…The special cylindrical geometry of MNWs gives rise to a well-dened magnetic anisotropy 16 that makes them suitable for many biological applications, such as MRI contrast, magnetic enrichment, and nanowarming. 11,[17][18][19][20][21] An external eld can be remotely used to physically excite MNWs, which makes them suitable for cell tracking, [22][23][24][25] cells manipulation, 26 cell separation, 27,28 drug delivery and drug activation, 29,30 magnetic hyperthermia, 21 and magneto-elastic ferrogels for tissue engineering. 31,32 Furthermore, the MNWs have shown a high internalization by cells in comparison to other magnetic nanoparticles, such as IONs, improving the enrichment and multiplexing yield.…”

Section: Introductionmentioning

confidence: 99%

Projection method as a probe for multiplexing/demultiplexing of magnetically enriched biological tissues

Kouhpanji

Stadler

2020

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Projection method as a probe for multiplexing/demultiplexing of magnetically enriched biological tissues

Kouhpanji

Stadler

2020

RSC Adv.

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“…Previously, the performance of Fe-based NWs and multisegmented Fe/gold NWs was assessed, where both types of NWs appeared to be promising T 2 CAs [30]. Similarly, an aqueous suspension of coated nickel NWs exhibited good performance for T 2 contrast with r 2 values similar to those of commercial Fe x O y NPs [31].…”

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confidence: 99%

Magnetic core–shell nanowires as MRI contrast agents for cell tracking

et al. 2020

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Background: Identifying the precise location of cells and their migration dynamics is of utmost importance for achieving the therapeutic potential of cells after implantation into a host. Magnetic resonance imaging is a suitable, non-invasive technique for cell monitoring when used in combination with contrast agents. Results: This work shows that nanowires with an iron core and an iron oxide shell are excellent materials for this application, due to their customizable magnetic properties and biocompatibility. The longitudinal and transverse magnetic relaxivities of the core-shell nanowires were evaluated at 1.5 T, revealing a high performance as T 2 contrast agents. Different levels of oxidation and various surface coatings were tested at 7 T. Their effects on the T 2 contrast were reflected in the tailored transverse relaxivities. Finally, the detection of nanowire-labeled breast cancer cells was demonstrated in T 2-weighted images of cells implanted in both, in vitro in tissue-mimicking phantoms and in vivo in mouse brain. Labeling the cells with a nanowire concentration of 0.8 μg of Fe/mL allowed the detection of 25 cells/µL in vitro, diminishing the possibility of side effects. This performance enabled an efficient labelling for high-resolution cell detection after in vivo implantation (~ 10 nanowire-labeled cells) over a minimum of 40 days. Conclusions: Iron-iron oxide core-shell nanowires enabled the efficient and longitudinal cellular detection through magnetic resonance imaging acting as T 2 contrast agents. Combined with the possibility of magnetic guidance as well as triggering of cellular responses, for instance by the recently discovered strong photothermal response, opens the door to new horizons in cell therapy and make iron-iron oxide core-shell nanowires a promising theranostic platform.

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“…The distinguishing factor between T 1 and T 2 agents is that T 1 is based on longitudinal magnetization recovery while T 2 is based on transverse magnetization decay [60]. In this regard, Fe and Ni NW have been shown to be useful T 2 contrast agents with Ni NW being comparable to commercial agents [61,62]. The effectiveness of NW in both therapeutics and diagnostics makes NW and magnetic NW an attractive prospect for designing theranostics systems for cancer.…”

Section: The Use Of Magnetic Nanowire As a Theranostics System In Cancermentioning

confidence: 99%

Multifunctional Magnetic Nanowires: Design, Fabrication, and Future Prospects as Cancer Therapeutics

Nana

Marimuthu

Kondiah

et al. 2019

Cancers

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Traditional cancer therapeutics are limited by factors such as multi-drug resistance and a plethora of adverse effect. These limitations need to be overcome for the progression of cancer treatment. In order to overcome these limitations, multifunctional nanosystems have recently been introduced into the market. The employment of multifunctional nanosystems provide for the enhancement of treatment efficacy and therapeutic effect as well as a decrease in drug toxicity. However, in addition to these effects, magnetic nanowires bring specific advantages over traditional nanoparticles in multifunctional systems in terms of the formulation and application into a therapeutic system. The most significant of which is its larger surface area, larger net magnetic moment compared to nanoparticles, and interaction under a magnetic field. This results in magnetic nanowires producing a greater drug delivery and therapeutic platform with specific regard to magnetic drug targeting, magnetic hyperthermia, and magnetic actuation. This, in turn, increases the potential of magnetic nanowires for decreasing adverse effects and improving patient therapeutic outcomes. This review focuses on the design, fabrication, and future potential of multifunctional magnetic nanowire systems with the emphasis on improving patient chemotherapeutic outcomes.

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Electrodeposited Fe and Fe–Au nanowires as MRI contrast agents

Cited by 51 publications

References 25 publications

Projection method as a probe for multiplexing/demultiplexing of magnetically enriched biological tissues

Projection method as a probe for multiplexing/demultiplexing of magnetically enriched biological tissues

Magnetic core–shell nanowires as MRI contrast agents for cell tracking

Multifunctional Magnetic Nanowires: Design, Fabrication, and Future Prospects as Cancer Therapeutics

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