Electrodepositing salicylate modified PHEMA on stainless steel surface for hemocompatibility

Chen, B.; Chen, J.; Yang, Liming; Zhao, Guochen; Ding, Guangwei

doi:10.1179/1743294414y.0000000313

Cited by 1 publication

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Applications for p(HEMA) include wear resistant hydrophilic surface coatings for prosthetics [5], antimicrobial wound dressings [6], intramuscular biosensor http://dx.doi.org/10.1016/j.eurpolymj.2015.07.035 0014-3057/Ó 2015 Elsevier Ltd. All rights reserved. coatings [7], tissue engineering scaffolds [8], generation of bone-like materials [9], imparting hemocompatibility to metal surfaces [10], improving hardness and elasticity of brittle substrates [11], soft contact lenses [12], and sophisticated drug delivery systems [13][14][15]. When conferred with pH and/or biologically derived responsiveness, poly(HEMA)-based hydrogels have been used in responsive drug delivery with engineered feedback control [14,[16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Partitioning of coomassie brilliant blue into DMAEMA containing poly(HEMA)-based hydrogels

Kotanen

Janagam

Idziak

et al. 2015

European Polymer Journal

View full text Add to dashboard Cite

a b s t r a c tThe loading and release of anti-inflammatory drugs from hydrogel-coated implantable devices is a demonstrated approach in mitigating the inflammatory response of implantable devices. Poly(2-hydroxyethyl methacrylate)-based hydrogels possessing ionizable 2-(dimethylamino)ethyl methacrylate (DMAEMA) and cross-linked with varying concentrations (1, 3, 5, 7, 9 and 12 mol%) tetra(ethylene glycol) diacrylate (TEGDA) were synthesized and studied for their degree of hydration, glass transition temperature and partitioning of zwitterionic Coomassie Brilliant Blue (CBB), a zwitterionic drug surrogate known to bind to amines. Using UV-Vis spectroscopy, the partition coefficient of CBB within the hydrogels was found to average 6.69 ± 0.12 but to rise monotonically from 6.54 (1 mol%) to 6.84 (12 mol%) as a function of TEGDA mol% or cross-link density in accord with a monotonic reduction of the degree of hydration. The absence of DMAEMA was found to reduce the partition coefficient of CBB from 6.5 to 4.1. Both formulations, with and without DMAEMA (pK a = 7.5), showed an independence of pH over the physiologically relevant range, pH 5-pH 9, confirming that this difference was not due to Henderson-Hasselbalch ionization of the pendant group. The presence of DMAEMA resulted in a 1.44 fold increase in CBB loading confirming complex formation. The absence of DMAEMA still resulted in considerable partitioning of CBB into the hydrogel suggesting that the affinity between CBB and DMAEMA may not be the only relationship controlling the partition coefficient.

show abstract