Electrodeposition of Ca–P coatings on biodegradable Mg alloy: In vitro biomineralization behavior☆

Song, Yang; Zhang, Shaoxiang; Li, Jianan; Zhao, Changli; Zhang, Xiaonong

doi:10.1016/j.actbio.2009.12.020

Cited by 346 publications

(181 citation statements)

References 19 publications

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“…35 The surface modification of magnesium substrate can significantly decrease the corrosion rate leading to less change in pH value and Mg ion release. 33 In our study, FHA/MAO coating on the magnesium substrate reduces the pH increase and Mg ion release leads to the best cell viability compared to other samples. Moreover, having calcium element in the chemical composition of FHA coating can be helpful on the cellular behavior, as it improves the chemical signaling of the cells and absorbs fibronectin and vitronectin proteins which are crucial elements on the biological function of the cells.…”

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confidence: 92%

“…It not only can produce a porous template for the EPD coating layer, but it also can act as a barrier layer for corrosion attacks due to the existence of MgO in its chemical composition. 22,29 There has been some research separately on MAO coating, 29,30,31 and FHA coating by electrodeposition technique 32,33 on magnesium alloys. In our previous work, we employed a combination of MAO and EPD techniques for the surface modification of AZ91 magnesium alloy by FHA coating which exhibits a significant property enhancement of implants.…”

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confidence: 99%

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In vivo assessments of bioabsorbable AZ91 magnesium implants coated with nanostructured fluoridated hydroxyapatite by MAO/EPD technique for biomedical applications

Razavi

Fathi

Savabi

et al. 2015

Materials Science and Engineering: C

100

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Although magnesium (Mg) is a unique biodegradable metal which possesses mechanical property similar to that of the natural bone and can be an attractive material to be used as orthopedic implants, its quick corrosion rate restricts its actual clinical applications. To control its rapid degradation, we have modified the surface of magnesium implant using fluoridated hydroxyapatite (FHA: Ca10(PO4)6OH2 − xFx) through the combined micro-arc oxidation (MAO) and electrophoretic deposition (EPD) techniques, which was NOT THE PUBLISHED VERSION; this is the author's final, peer-reviewed manuscript. The published version may be accessed by following the link in the citation at the bottom of the page. 2015): pg. 21-27. DOI. This article is © Elsevier and permission has been granted for this version to appear in e-Publications@Marquette. Elsevier does not grant permission for this article to be further copied/distributed or hosted elsewhere without the express permission from Elsevier. Materials Science and Engineering: C, Vol 48 (March3 presented in our previous paper. In this article, the biocompatibility examinations were conducted on the coated AZ91 magnesium alloy by implanting it into the greater trochanter area of rabbits. The results of the in vivo animal test revealed a significant enhancement in the biocompatibility of FHA/MAO coated implant compared to the uncoated one. By applying the FHA/MAO coating on the AZ91 implant, the amount of weight loss and magnesium ion release in blood plasma decreased. According to the histological results, the formation of the new bone increased and the inflammation decreased around the implant. In addition, the implantation of the uncoated AZ91 alloy accompanied by the release of hydrogen gas around the implant; this release was suppressed by applying the coated implant. Our study exemplifies that the surface coating of magnesium implant using a bioactive ceramic such as fluoridated hydroxyapatite may improve the biocompatibility of the implant to make it suitable as a commercialized biomedical product.

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confidence: 92%

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confidence: 99%

In vivo assessments of bioabsorbable AZ91 magnesium implants coated with nanostructured fluoridated hydroxyapatite by MAO/EPD technique for biomedical applications

Razavi

Fathi

Savabi

et al. 2015

Materials Science and Engineering: C

100

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“…Previous investigations have studied this fact more explicitly. 47,48 SEM micrographs of Mg scaffold (a, b), Mg scaffold/1PCL-BG (c, d) and Mg scaffold/3PCL-BG (e, f) after 48 h immersion in the SBF have been presented in Fig. 6.…”

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confidence: 99%

Surface modification of biodegradable porous Mg bone scaffold using polycaprolactone/bioactive glass composite

Yazdimamaghani

Razavi

Vashaee

et al. 2015

Materials Science and Engineering: C

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A reduction in the degradation rate of magnesium (Mg) and its alloys is in high demand to enable these materials to be used in orthopedic applications. For this purpose, in this paper, a biocompatible polymeric layer reinforced with a bioactive ceramic made of polycaprolactone (PCL) and bioactive glass (BG) was applied on the surface of Mg scaffolds using dipcoating technique under low vacuum. The results indicated that the PCL-BG coated Mg scaffolds exhibited noticeably enhanced bioactivity compared to the uncoated scaffold. Moreover, the mechanical integrity of the Mg scaffolds was improved using the PCL-BG coating on the surface. The stable barrier property of the coatings effectively delayed the degradation activity of Mg scaffold substrates. Moreover, the coatings induced the formation of apatite layer on their surface after immersion in the SBF, which can enhance the biological bone in-growth and block the microcracks and pore channels in the coatings, thus prolonging their protective effect. Furthermore, it was shown that a three times increase in the concentration of PCL-BG noticeably improved the characteristics of scaffolds including their degradation resistance and mechanical stability. Since bioactivity, degradation resistance and mechanical integrity of a bone substitute are the key factors for repairing and healing fractured bones, we suggest that PCL-BG is a suitable coating material for surface modification of Mg scaffolds.

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“…Song, Yang, et al [9] showed that both the HA and FHA (fluoridated hydroxyapatite) coating could promote the nucleation of osteoconductive minerals (bone-like apatite or β-TCP), while the precipitates on the uncoated Mg-Zn alloy in modified simulated biological fluid had low Ca/P molar ratios, which delayed bone-like apatite formation.…”

Section: Introductionmentioning

confidence: 99%

“…Ca and P are the major elements in bone minerals. Thus, Ca-P coatings, especially osteoconductive minerals such as hydroxyapatite (HA) and tricalcium phosphate (TCP), should be useful in constructing new bone and promoting osteointegration around Mg implants [9].…”

Section: Introductionmentioning

confidence: 99%

Effect of Adding Sb on Microstructure, Mechanical Properties and in <i>Vitro</i> Degradation Behavior of as Cast Mg-4wt% Zn Alloy for Medical Application

Mohamed¹,

Moussa²,

Waly³

et al. 2017

JSEMAT

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Magnesium (Mg) and its alloys are one of a novel kind of biodegradable metallic implants which attracted much fundamental research to develop its clinical application. Nevertheless, it has more restrictions in biomedical applications because it degrades too fast at the early stage after implantation, thus commonly leading to some problems such as early fast mechanical loss, hydric bubble aggregation, gap formation between the implants and the tissue. This work aims to study the effect of 0.5 wt% Sb addition on the microstructure, mechanical properties and degradation behavior of as cast Mg-4wt% Zn alloy. The evaluation process was conducted using optical and scanning electron microscopy, X-ray diffraction, tensile and compression tests, in addition to a corrosion study by immersing in simulated body fluid (SBF). Results showed that Sb refines the grain size of the base alloy and also enhances its mechanical properties and degradation rate as well. These were due to the formation of the secondary phase of Mg 3 Sb 2 . To get better degradation rate, the Mg-4wt% Zn and Mg-4wt% Zn-0.5wt% Sb alloys are coated with Ca-P using autocatalytic technique. The results demonstrated that the formed coat layer improves the degradation rate of samples under the condition of this study. The current study shows that Mg-4wt% Zn-0.5wt% Sb alloy has good mechanical properties and when it coated by Ca-P, it gave a better corrosion resistance that makes it ideal for biodegradable medical application.

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Electrodeposition of Ca–P coatings on biodegradable Mg alloy: In vitro biomineralization behavior☆

Cited by 346 publications

References 19 publications

In vivo assessments of bioabsorbable AZ91 magnesium implants coated with nanostructured fluoridated hydroxyapatite by MAO/EPD technique for biomedical applications

In vivo assessments of bioabsorbable AZ91 magnesium implants coated with nanostructured fluoridated hydroxyapatite by MAO/EPD technique for biomedical applications

Surface modification of biodegradable porous Mg bone scaffold using polycaprolactone/bioactive glass composite

Effect of Adding Sb on Microstructure, Mechanical Properties and in <i>Vitro</i> Degradation Behavior of as Cast Mg-4wt% Zn Alloy for Medical Application

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Electrodeposition of Ca–P coatings on biodegradable Mg alloy: In vitro biomineralization behavior☆

Cited by 346 publications

References 19 publications

In vivo assessments of bioabsorbable AZ91 magnesium implants coated with nanostructured fluoridated hydroxyapatite by MAO/EPD technique for biomedical applications

In vivo assessments of bioabsorbable AZ91 magnesium implants coated with nanostructured fluoridated hydroxyapatite by MAO/EPD technique for biomedical applications

Surface modification of biodegradable porous Mg bone scaffold using polycaprolactone/bioactive glass composite

Effect of Adding Sb on Microstructure, Mechanical Properties and in &lt;i&gt;Vitro&lt;/i&gt; Degradation Behavior of as Cast Mg-4wt% Zn Alloy for Medical Application

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Effect of Adding Sb on Microstructure, Mechanical Properties and in <i>Vitro</i> Degradation Behavior of as Cast Mg-4wt% Zn Alloy for Medical Application