Electrodeposition on Nanofibrous Polymer Scaffolds: Rapid Mineralization, Tunable Calcium Phosphate Composition and Topography

He, Chang; Xiao, Gui‐yong; Jin, Xun; Sun, Chenghui; Peter, X.

doi:10.1002/adfm.201000993

Cited by 100 publications

(85 citation statements)

References 46 publications

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“…However, static mineralization is very time consuming because the solution has to be changed every 2 h and yields nonuniform mineralization throughout the scaffold. 30,31 Flow mineralization, on the other hand, utilizes a pump to actively flow the SBF solution through a chamber in which the scaffolds are housed. The advantages of using flow mineralization include a rapid and an active replacement of the SBF solution.…”

Section: Comparing Mineralization Techniques (Flow Vs Static)mentioning

confidence: 99%

Investigating processing techniques for bovine gelatin electrospun scaffolds for bone tissue regeneration

Taylor

Limaye

Yarborough

et al. 2016

J. Biomed. Mater. Res.

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Tissue engineering has emerged as a promising solution to tissue regeneration in the case of significant bone loss due to disease or injury. The ability to promote cellular attachment, migration, and differentiation into tissue is dependent on the scaffold's surface properties and composition. Bovine gelatin is a natural polymer commonly used as a scaffolding material for tissue engineering applications. Nonetheless, due to the hydrophilic behavior of gelatin, cross-linking and additives are necessary to maintain the scaffold's structure and overall strength in vivo. In this article, we discuss various processing techniques to determine the optimal electrospinning, cross-linking, sintering, and mineralization parameters necessary to yield a porous, mechanically enhanced scaffold. The scaffolds were evaluated quantitatively using compressive mechanical testing, and qualitatively using scanning electron microscopy (SEM). Mechanical data concluded the use of biocompatible microbial transglutaminase (mTG) as a cross-linking agent, led to increased compressive strength. SEM images confirmed the presence of individual gelatin and polymeric nanofibers woven into one scaffold. Sintering before leaching the scaffold yielded structured pores throughout the three-dimensional scaffold when compared to the scaffolds that were leached prior to sintering. The results presented in this article will provide novel information about processing techniques that can be utilized to develop a hybrid synthetic and biological based biomimetic mineralized scaffold for trabecular bone tissue regeneration. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1131-1140, 2017.

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Section: Comparing Mineralization Techniques (Flow Vs Static)mentioning

confidence: 99%

Investigating processing techniques for bovine gelatin electrospun scaffolds for bone tissue regeneration

Taylor

Limaye

Yarborough

et al. 2016

J. Biomed. Mater. Res.

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“…Ideally, the scaffolding materials should also be a mimic of the natural extracellular matrix (ECM) of the target tissue by integrating suitable mechanical, structural, and biological signals into scaffold [2]. To this end, a wide range of natural biopolymer-based scaffolds have been proposed for tissue repair or regeneration during the past years.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of gelatin–hyaluronic acid hybrid scaffolds with tunable porous structures for soft tissue engineering

Zhang

Cao

et al. 2011

International Journal of Biological Macromolecules

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135

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“…For example, it usually requires several weeks to form a mineralized HA layer on the surface of pure PLA polymer. 40,41 The result can be explained by the hydrophobic properties of PLA polymer which cannot supply active groups or sites for the mineralization. 23,42 The result obtained for PLA nanofibers also indicated poor mineralization.…”

mentioning

confidence: 99%

Electrospinning of calcium phosphate-poly(D,L-lactic acid) nanofibers for sustained release of water-soluble drug and fast mineralization

Fu¹,

Zi²,

Xu³

et al. 2016

IJN

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Calcium phosphate-based biomaterials have been well studied in biomedical fields due to their outstanding chemical and biological properties which are similar to the inorganic constituents in bone tissue. In this study, amorphous calcium phosphate (ACP) nanoparticles were prepared by a precipitation method, and used for preparation of ACP-poly( d , l -lactic acid) (ACP-PLA) nanofibers and water-soluble drug-containing ACP-PLA nanofibers by electrospinning. Promoting the encapsulation efficiency of water-soluble drugs in electrospun hydrophobic polymer nanofibers is a common problem due to the incompatibility between the water-soluble drug molecules and hydrophobic polymers solution. Herein, we used a native biomolecule of lecithin as a biocompatible surfactant to overcome this problem, and successfully prepared water-soluble drug-containing ACP-PLA nanofibers. The lecithin and ACP nanoparticles played important roles in stabilizing water-soluble drug in the electrospinning composite solution. The electrospun drug-containing ACP-PLA nanofibers exhibited fast mineralization in simulated body fluid. The ACP nanoparticles played the key role of seeds in the process of mineralization. Furthermore, the drug-containing ACP-PLA nanofibers exhibited sustained drug release which simultaneously occurred with the in situ mineralization in simulated body fluid. The osteoblast-like (MG63) cells with spreading filopodia were well observed on the as-prepared nanofibrous mats after culturing for 24 hours, indicating a high cytocompatibility. Due to the high biocompatibility, sustained drug release, and fast mineralization, the as-prepared composite nanofibers may have potential applications in water-soluble drug loading and release for tissue engineering.

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Electrodeposition on Nanofibrous Polymer Scaffolds: Rapid Mineralization, Tunable Calcium Phosphate Composition and Topography

Cited by 100 publications

References 46 publications

Investigating processing techniques for bovine gelatin electrospun scaffolds for bone tissue regeneration

Investigating processing techniques for bovine gelatin electrospun scaffolds for bone tissue regeneration

Fabrication of gelatin–hyaluronic acid hybrid scaffolds with tunable porous structures for soft tissue engineering

Electrospinning of calcium phosphate-poly(D,L-lactic acid) nanofibers for sustained release of water-soluble drug and fast mineralization

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