Electrodiagnostic and Clinical Aspects of Guillain-Barré Syndrome: An Analysis of 142 Cases

Background:Guillain-Barré syndrome (GBS) is an acute inflammatory polyneuropathy commonly characterized by rapidly progressive, symmetric weakness and areflexia.Materials and Methods:We retrospectively assessed the clinical manifestations, results of electrodiagnostic tests, functional status and prognosis of 36 children diagnosed with GBS.Results:Based on clinical and electrophysiological findings, the patients were classified as having acute inflammatory demyelinating polyradiculoneuropathy (AIDP) (n = 25), acute motor axonal neuropathy (AMAN) (n = 10) and acute motor-sensory axonal neuropathy (AMSAN) (n = 1). Twenty (55.5%) patients were males and 16 (44.5%) patients were females. The mean age of the 36 patients was 68.1 ± 45.01 months (range, 6–180 months). Five (13.8%) patients were younger than 2 years. The most common initial symptoms were limb weakness, which was documented in 34 (94.4%) patients. In our study, 18 patients (51.4%) showed albuminocytological dissociation (raised protein concentration without pleocytosis) on cerebrospinal fluid (CSF) examination. Three patients (8.3%) required mechanical ventilation therapy during hospitalization. Unfortunately, three (8.3%) patients died; one patient had AIDP and two patients had axonal involvement (one case was AMAN and another case was AMSAN). When we compared the cases of residual sequel/dead and cases of complete recovery for neural involvement type including AIDP, AMAN and AMSAN, we did not find a statistically significant difference between the groups (P > 0.05).Conclusion:Our findings showed that cases of GBS was not uncommon in children younger than 2 years of age, and CSF protein level might be found high in the first week of the disease in about one half of the patients, with a higher rate of morbidity and mortality in patients with axonal involvement than in those with AIDP.

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“…In our study, the patients were classified into AIDP or AMAN based on the existing electrodiagnostic criteria. [10]…”

Section: Methodsmentioning

confidence: 99%

Clinical features and prognosis with Guillain-Barré syndrome

Akbayram

Doğan

Akgün

et al. 2011

Ann Indian Acad Neurol

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“…In Indian series the incidence of AIDP and AMAN are virtually equal although AMAN is more common in younger patients. [8] There seems to be a slight preponderance of AIDP in studies by Gupta et al [9] and by Meena et al (unpublished data from NIMS, Hyderabad). Available Indian literature indicates a peak incidence between June–July and Sept–October.…”

Section: Epidemiologymentioning

confidence: 97%

Treatment guidelines for Guillain-Barré Syndrome

Meena

Khadilkar

Murthy

2011

Ann Indian Acad Neurol

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“…The most common variant of GBS was AIDP followed by AMAN. Other studies from different parts of the world have reported 80-90 per cent frequency from Europe and the USA1819 and Indian studies reporting 48.8 to 85.2 per cent202122. A large study from northern India comprising 328 patients reported AIDP in 73.8 per cent patients and better outcome compared to AMAN6.…”

Section: Discussionmentioning

confidence: 95%

Guillain–Barre syndrome

Shrivastava

Shah

Navaid

2017

Indian Journal of Medical Research

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Background & objectives: Guillain–Barre syndrome (GBS) is an autoimmune disease and a recognized cause of generalized progressive paralysis worldwide. The present study was aimed to document the clinical findings, demographics and seasonal variations amongst the patients with GBS during the hospital stay. Methods: A retrospective analysis of 66 referred cases diagnosed as GBS was conducted. Medical records and the data related to age, sex, antecedent illness, duration of symptoms before admission, muscle power graded by the Medical Research Council scale, functional scores, details of Intensive Care Unit complications and need for ventilation were obtained. The patients were divided into four seasonal groups: S1 (spring, February to April), S2 (summer, May to July), S3 (rainy, August to October) and S4 (winter, November to January) and parameters were studied. Results: The mean age of the patients was 40.69 yr. Forty one (62.1%) patients had a history of preceding illness. Forty nine (74.2%) patients showed quadriparesis as most common complaint. Thirty three (50%) patients were of acute inflammatory demyelinating polyneuropathy (AIDP) variant. The highest number of GBS cases (60%) was found in S1 and S2. The maximum duration of hospital stay was observed in S3 group (mean 23 days). Interpretation & conclusions: GBS seems to affect all age groups with male preponderance. Most common antecedent event and presenting feature were flu-like illness and quadriparesis, respectively. AIDP was the most common variant. Most cases occurred from February to July (S1 and S2 group) (maximum in July) with preceding influenza and diarrhoea and maximum duration of hospital stay was observed in S3 group. Prospective studies with follow up of GBS patients need to be done to confirm findings.

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Electrodiagnostic and Clinical Aspects of Guillain-Barré Syndrome: An Analysis of 142 Cases

Cited by 28 publications

References 36 publications

Clinical features and prognosis with Guillain-Barré syndrome

Clinical features and prognosis with Guillain-Barré syndrome

Treatment guidelines for Guillain-Barré Syndrome

Guillain–Barre syndrome

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