Electroencephalogram changes during inhalation with nitric oxide in the pediatric intensive care patient-A preliminary report

Abstract

These preliminary data suggest the occurrence of EEG-abnormalities after application of inhaled NO in critically ill children. We found no correlation with other potential EEG-influencing parameters, although clinical state, medication, or hypoxemia might contribute. Comprehensive, prospective, clinical assessment regarding a causal relationship between NO-inhalation and EEG-abnormalities and their clinical importance is needed.

Neurodevelopmental outcome in high‐risk preterm infants treated with inhaled nitric oxide

“…Animal studies have demonstrated an increased incidence of abnormal behaviour and learning processes in addition to a prolongation of auditory evoked responses (5). Inhaled NO therapy in children receiving mechanical ventilation is associated with abnormal electroencephalogram changes (6). In preterm neonates, there has been considerable concern surrounding abnormal platelet aggregation and prolongation of bleeding time resulting in a potential increased incidence of intracranial haemorrhage with iNO therapy (7).…”