Electroencephalographic correlates of blood flow and oxygen metabolism provided by positron emission tomography in patients with cerebral infarction

Nagata, Ken; Tagawa, Koichi; Hiroi, Satoru; Shishido, Fumio; Uemura, Kazunori

doi:10.1016/0013-4694(89)90027-8

Cited by 128 publications

(79 citation statements)

References 31 publications

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“…Later studies confirmed that the most frequent findings based on visual EEG analysis are focal delta or theta activities, often associated with decreased background alpha activity [13]. Spectral analysis of the waking EEG revealed increased delta activity and decreased alpha activity over the affected hemisphere [14, 15, 16]. Murri et al [17]reported a relation between the spatial localization of the maximum delta power and the topography of the lesion based on brain computer tomogram.…”

Section: Introductionmentioning

confidence: 60%

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Visual and Spectral Analysis of Sleep EEG in Acute Hemispheric Stroke

et al. 2002

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Background: Reports on the effects of focal hemispheric damage on sleep EEG are rare and contradictory. Patients and Methods: Twenty patients (mean age ± SD 53 ± 14 years) with a first acute hemispheric stroke and no sleep apnea were studied. Stroke severity [National Institute of Health Stroke Scale (NIHSS)], volume (diffusion-weighted brain MRI), and short-term outcome (Rankin score) were assessed. Within the first 8 days after stroke onset, 1–3 sleep EEG recordings per patient were performed. Sleep scoring and spectral analysis were based on the central derivation of the healthy hemisphere. Data were compared with those of 10 age-matched and gender-matched hospitalized controls with no brain damage and no sleep apnea. Results: Stroke patients had higher amounts of wakefulness after sleep onset (112 ± 53 min vs. 60 ± 38 min, p < 0.05) and a lower sleep efficiency (76 ± 10% vs. 86 ± 8%, p < 0.05) than controls. Time spent in slow-wave sleep (SWS) and rapid eye movement (REM) sleep and total sleep time were lower in stroke patients, but differences were not significant. A positive correlation was found between the amount of SWS and stroke volume (r = 0.79). The slow-wave activity (SWA) ratio NREM sleep/wakefulness was lower in patients than in controls (p < 0.05), and correlated with NIHSS (r = –0.47). Conclusion: Acute hemispheric stroke is accompanied by alterations of sleep EEG over the healthy hemisphere that correlate with stroke volume and outcome. The increased SWA during wakefulness and SWS over the healthy hemisphere contralaterally to large strokes may reflect neuronal hypometabolism induced transhemispherically (diaschisis).

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Section: Introductionmentioning

confidence: 60%

“…Finally, there is increasing evidence that EEG changes may also occur in the healthy hemisphere during recovery after a focal cerebral lesion [28]. A few studies reported, for example, a slowing of the waking EEG over the nonaffected hemisphere [14, 29]. …”

Section: Introductionmentioning

confidence: 99%

Visual and Spectral Analysis of Sleep EEG in Acute Hemispheric Stroke

et al. 2002

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“…Studies of CBF and cerebral rate of oxygen metabolism (CMRO 2 ) using Xenon computed tomography (CT) and positron emission tomography (PET) in ischemic stroke have demonstrated that regional EEG changes also refl ect the coupling of CBF and metabolism [14]. In early subacute ischemic stroke, the EEG correlates well with CBF as the oxygen extraction fraction increases to preserve CMRO 2 , a period termed "misery perfusion" or stage 2 hemodynamic failure [14,15].…”

Section: Eeg Changes In Ischemiamentioning

confidence: 99%

“…Cerebral perfusion pressure (CPP), related to CBF and to ICP, correlates with decreases in mean frequency as CPP falls below 60 mmHg, even in comatose or sedated patients [30]. Finally, increased power in slower frequency bands (delta and theta) and decreased power in faster frequency bands (alpha and beta) are seen with reduc tions in brain metabolism (CMRO 2 ) [14]. Overall, the rela tive delta percentage appears to provide the most robust correlation with CBF and metabolism during focal ischemia.…”

Section: Quantitative Eeg In Ischemiamentioning

confidence: 99%

Quantitative EEG for the Detection of Brain Ischemia

Foreman¹,

Claassen²

2012

Annual Update in Intensive Care and Emergency Medicine 2012

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“…42 The usefulness of electroencephalography has been demonstrated during NM monitoring of surgical treatment of cerebral aneurysm clipping, 43 carotid artery clamping, and during CEA. 43 In patients undergoing CEA, major electroencephalography changes occur with marked electric attenuation and slowing with cerebral blood flow values <10 mL/100 g per minute, with the critical level defined as 15 mL/100 g per minute.…”

Section: Electroencephalography and Quantitative Electroencephalograpmentioning

confidence: 99%