Electroencephalographic Effects of Bilateral Prefrontal Lobotomy

Levin, Sarah; Greenblatt, Milton; Healey, Marie M.; Solomon, Harry C.

doi:10.1176/ajp.106.3.174

Cited by 12 publications

(1 citation statement)

References 9 publications

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“…While these findings confirmed previous observations in non-stereotactic psychosurgery and ECT (Levin et al, 1949;Roth et al, 1957), they indicate that the lesions have a profound immediate effect on fronto-thalamic loops and that the extent of this effect has a predictive value on the final outcome, despite the fact that clinical improvement does not usually manifest itself for a number of months after surgery (Mindus, 1991;Bridges et al, 1994;Poynton et al, 1995).…”

Section: Electroencephalograms (Eeg) and Psychophysiologysupporting

confidence: 88%

The frontal lobes and neurosurgery for psychiatric disorders

Malizia

1997

J Psychopharmacol

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The frontal lobe has been the main target for surgical treatment of mental illness over the last 60 years. Initially the surgery was crude and performed on patients with many different psychiatric disorders. Contemporary surgery utilizes stereotactic lesions which interrupt fronto-thalamic and/or fronto-cingulate fibres. The findings of clinical, neurochemical, neuroimaging, neuropsychological and physiological research in this area are summarized. Current advances in clinical neuroscience methods should be used in patients with these lesions to elucidate the neural substrate of post-operative changes and optimize clinical practice.

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Section: Electroencephalograms (Eeg) and Psychophysiologysupporting

confidence: 88%

The frontal lobes and neurosurgery for psychiatric disorders

Malizia

1997

J Psychopharmacol

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Clinical and Electroencephalographic Effects of Prefrontal Lobotomy and Topectomy in Chronic Psychoses

Krueger¹,

Wayne²

1952

Arch NeurPsych

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Case Material and Procedures.\p=m-\Withthe exception of one patient with manic-depressive psychosis, all had chronic advanced schizophrenia of paranoid, hebephrenic, or catatonic type. A comparative study of the effects of prefrontal lobotomy and topectomy seemed to be particularly applicable in a rather homogeneous group of patients with advanced schizophrenia.A selection of the patients for one or the other procedure was deliberately avoided. All 105 patients\p=m-\84 from the Northport Veterans Administration Hospital, 17 from the Canandaigua Veterans Administration Hospital, and four from other hospitals\p=m-\wereselected for psychosurgical procedures by the lobotomy boards of the various hospitals, according to several criteria. The duration of illness was at least two or three years, with an average duration of five years. All patients had had previous treatment, consisting of institutional care, electric shock, or insulin coma, resulting in little or no improvement. Most patients came from the wards for disturbed patients and constituted grave problems in management. Their symptoms ranged from violent, destructive, assaultive, homicidal, suicidal, or agitated behavior to apathy, complete withdrawal, and marked deterioration, with lack of control of bodily functions. Several patients had required prolonged tube feeding, and many had been under continuous medical sedation or pack therapy for a long period. The prognosis was considered extremely poor in all cases. The majority of the patients, mostly of similar social background, were young to middle-aged male veterans of World War II, with an average age of approximately 30. After transfer to the Bronx Veterans Administration Hospital, the patients were reevaluated for the advisability of psychosurgery after a preoperative observation period of two to four weeks, during which time various laboratory procedures and psychological tests were per-

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Incidence of Seizures, with EEG Findings, in Prefrontal Lobotomy

Klotz¹

1955

Arch NeurPsych

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Electroencephalographic Effects of Bilateral Prefrontal Lobotomy

Cited by 12 publications

References 9 publications

The frontal lobes and neurosurgery for psychiatric disorders

The frontal lobes and neurosurgery for psychiatric disorders

Clinical and Electroencephalographic Effects of Prefrontal Lobotomy and Topectomy in Chronic Psychoses

Incidence of Seizures, with EEG Findings, in Prefrontal Lobotomy

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