Electrogenerated chemiluminescence quenching of Ru(bpy)32+ (bpy=2,2′-bipyridine) in the presence of acetaminophen, salicylic acid and their metabolites

Haslag, Catherine S.; Richter, Mark M.

doi:10.1016/j.jlumin.2011.09.059

Cited by 15 publications

(9 citation statements)

References 64 publications

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“…Up to now, several methods have been developed for detection of DA and AC, including capillary electrophoresis [10], chromatography [11], chemiluminescence [12], spectrophotometric [13], and electrochemical method [14,15]. Among them, electrochemical methods are widely used, owing to their intrinsic advantages such as rapid response, high sensitivity, easy operation, and low cost.…”

Section: Introductionmentioning

confidence: 99%

A glassy carbon electrode modified with porous gold nanosheets for simultaneous determination of dopamine and acetaminophen

et al. 2014

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Porous gold nanosheets modified glassy carbon electrode (GCE) was facilely prepared by one-step electrodeposition, using N-methylimidazole as a growth-directing agent. The porous gold nanosheets modified GCE was characterized by scanning electron microscopy, transmission electron microscopy, and X-ray diffraction spectroscopy. The modified electrode displayed improved sensitivity for individual and simultaneous differential pulse voltammetric determination of dopamine (DA; at 180 mV) and acetaminophen (AC; at 450 mV vs. Ag/AgCl) even in the presence of ascorbic acid. The oxidation peak currents linearly increased with the concentrations of DA and AC in the ranges from 2.0 to 298.0 μM and 3.0 to 320.0 μM, respectively, and the detection limits are 0.28 μM for DA and 0.23 μM for AC. The relative standard deviations (n=20) are 1.5 % for DA and 0.4 % for AC.

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Section: Introductionmentioning

confidence: 99%

A glassy carbon electrode modified with porous gold nanosheets for simultaneous determination of dopamine and acetaminophen

et al. 2014

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“…This behavior can be explained in terms of producing ECL from a redox reaction of [Ru(bpy) 3 ] 2+ and Ketamine as observed previously for amines in water (Scheme 3). 26 The ECL intensities of Ketamine were measured as shown in Table II. This table illustrates The blank also presents an ECL emission value, this is due to the presence of chloride ions coming from tris-(2,2 -bipyridyl) ruthenium(II) dichloride hexahydrate in aqueous medium.…”

Section: Resultsmentioning

confidence: 99%

“…[17][18][19][20] It has been widely employed in biological matrixes, 21 pharmaceutical 22 and some drugs containing tertiary amine functional group 21,[23][24][25] due to its continuance, sensitivity, reproducibility and selectivity toward many target analytes. 21,24,26,27 Generally, the amino group present in amine produces a secondary amine following by a dealkylation process in the presence of water. The radical cation of the amine is able to react with [Ru(bpy) 3 28 This is the first time that the electroanalytical sensing of Ketamine in buffer solution using ECL has been reported.…”

Section: Ketamine (K) [2-(-o-chlorophenyl)-2-(methylamino)-cyclohexanmentioning

confidence: 99%

Electroanalytical Sensing of Ketamine Using Electrogenerated Chemiluminescence

Lledo-Fernandéz

Pollard

Kruanetr

2013

J. Electrochem. Soc.

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The electro-analytical sensing of Ketamine is reported for the first time utilizing [Ru(bpy) 3 ] 2+ as a Electrochemiluminescent reagent probe. The niche of this electro-analytical method is the lack of any sample pre-treatment as well as being cost and time effective. The methodology is shown to be useful for quantifying low levels, ng/mL, Ketamine in not only buffered solutions but also in an alcoholic beverage. We have successfully demonstrated the detection of Ketamine over a range of Ketamine concentrations 2000 ng/mL to 50 ng/mL in buffer solution. A linear response is observed (ECL emission/mV = 0.0098x+6.120, R 2 = 0.9915 and N = 5) with a detection limit of 33 ng/mL (based on 3-sigma). The proposed method was successfully applied to the determination of Ketamine in an alcoholic beverage sample -Gordon's Gin & Tonic. , is a synthetic, sedative, non-barbiturate, and fast acting anesthetic, which is able to block the receptor of N-methyl-d-asparate (NMDA) and is believed to affect opioid, adrenergic, cholinergic and serotonin receptors.1,2 Ketamine is a drug used in human and veterinary medicine, primarily for the induction and maintenance of general anesthesia, usually in combination with a sedative 3-5 (which is depicted in Figure 1).The increase in illicit use prompted ketamine's placement in Schedule III of the United States Controlled Substance Act in August 1999. 5,6 It became labeled a Class C drug on 1 January 2006 in the United Kingdom. 6 The recreational use of Ketamine has increased popularity worldwide over the last 10 years. 3,5 In fact, ketamine has surpassed other club drugs and even replaced heroin as the predominant drug of abuse in Hong Kong since the early 2000 7 with user experiencing hallucinations and a cataleptic state called the "K-hole." 5,6 Ketamine is generally analyzed by using immunoassays, 8 Liquid Chromatography-Mass Spectroscopy (LC-MS) 2,9,10 or Gas Chromatography-Mass Spectroscopy (GC-MS) 11-13 methodologies in biological matrixes. The drawbacks to these methods are that the times for the analysis are longer than 6 minutes per sample and a liquidliquid extraction prior to analysis is also needed.14-16 Tu et al. 8 reported an electrochemical impedimetric immunosensor for determining Ketamine in buffered samples. This method offers very low detection limits.Electrochemiluminescence (ECL) is an advantageous analytical tool, which is cost effective, portable and fast. [Ru(bpy) 3 ] 2+ is one the most important ECL reagents and the most widely used complexes for analytical investigations and applications owing to their excellent intrinsic characteristics. [17][18][19][20] It has been widely employed in biological matrixes, 21 pharmaceutical 22 and some drugs containing tertiary amine functional group 21,23-25 due to its continuance, sensitivity, reproducibility and selectivity toward many target analytes. 21,24,26,27 Generally, the amino group present in amine produces a secondary amine following by a dealkylation process in the presence of water. The radical cation of the ami...

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“…Typical ECL reagents, such as luminol and tris (2,2′-bipyridyl) ruthenium (II) (Ru(bpy) 3 2+ ), have been used extensively in various fields (Chu et al 2012;Haslag and Richter 2012). The detection of many species (or coreactants) has been demonstrated by virtue of their ability to generate light during reactions with the oxidized form of the complex.…”

Section: Introductionmentioning

confidence: 99%

Enhanced electrogenerated chemiluminescence of tris(2,2′-bipyridyl)ruthenium(II) system by l-cysteine-capped CdTe quantum dots and its application for the determination of nitrofuran antibiotics

Taokaenchan

Tangkuaram

Pookmanee

et al. 2015

Biosensors and Bioelectronics

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Electrogenerated chemiluminescence quenching of Ru(bpy)32+ (bpy=2,2′-bipyridine) in the presence of acetaminophen, salicylic acid and their metabolites

Cited by 15 publications

References 64 publications

A glassy carbon electrode modified with porous gold nanosheets for simultaneous determination of dopamine and acetaminophen

A glassy carbon electrode modified with porous gold nanosheets for simultaneous determination of dopamine and acetaminophen

Electroanalytical Sensing of Ketamine Using Electrogenerated Chemiluminescence

Enhanced electrogenerated chemiluminescence of tris(2,2′-bipyridyl)ruthenium(II) system by l-cysteine-capped CdTe quantum dots and its application for the determination of nitrofuran antibiotics

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