Electrogenerated Chemiluminescent Detection of Polyamines on a Microfluidic Device Using Micromolded Carbon Paste Microelectrodes

Gross, Erin M.; Lowry, Emily R.; Schaffer, Leah V.; Henry, Charles S.

doi:10.1002/elan.202100410

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…Cu 2+ —2-carboxymethylthio-5-mercapto-1,3,4-thiadiazole-functionalized organic thin-film transistors (OTFTs) exhibit the detection and discrimination of multi-polyamines [ 99 ]. The electrochemiluminescent (ECL) method was developed for the detection of several polyamines on a microfluidic chip [ 100 ]. An ultrahigh-performance supercritical fluid chromatography (UHPSFC) method was utilized for polyamine detection in gentamicin sulfate [ 101 ].…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Recent Advances in Fluorescent Methods for Polyamine Detection and the Polyamine Suppressing Strategy in Tumor Treatment

Wang

Ran

et al. 2022

Biosensors

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The biogenic aliphatic polyamines (spermine, spermidine, and putrescine) are responsible for numerous cell functions, including cell proliferation, the stabilization of nucleic acid conformations, cell division, homeostasis, gene expression, and protein synthesis in living organisms. The change of polyamine concentrations in the urine or blood is usually related to the presence of malignant tumors and is regarded as a biomarker for the early diagnosis of cancer. Therefore, the detection of polyamine levels in physiological fluids can provide valuable information in terms of cancer diagnosis and in monitoring therapeutic effects. In this review, we summarize the recent advances in fluorescent methods for polyamine detection (supramolecular fluorescent sensing systems, fluorescent probes based on the chromophore reaction, fluorescent small molecules, and fluorescent nanoparticles). In addition, tumor polyamine-suppressing strategies (such as polyamine conjugate, polyamine analogs, combinations that target multiple components, spermine-responsive supramolecular chemotherapy, a combination of polyamine consumption and photodynamic therapy, etc.) are highlighted. We hope that this review promotes the development of more efficient polyamine detection methods and provides a comprehensive understanding of polyamine-based tumor suppressor strategies.

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Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Recent Advances in Fluorescent Methods for Polyamine Detection and the Polyamine Suppressing Strategy in Tumor Treatment

Wang

Ran

et al. 2022

Biosensors

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Polyamines: The Gleam of Next-Generation Plant Growth Regulators for Growth, Development, Stress Mitigation, and Hormonal Crosstalk in Plants—A Systematic Review

Jangra

Chaturvedi²,

Kumar³

et al. 2022

J Plant Growth Regul

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Comparison of Mobile Phone and CCD Cameras for Electrochemiluminescent Detection of Biogenic Amines

Heckenlaible

Snyder

Herchenbach

et al. 2022

Sensors

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Biogenic amines are an important and widely studied class of molecules due to their link to the physiological processes of food-related illnesses and histamine poisoning. Electrochemiluminescent (ECL) detection offers an inexpensive and portable analytical method of detection for biogenic amines when coupled with recent advancements in low-cost carbon-based electrodes and a smartphone camera. In this work, a mobile phone camera was evaluated against a piece of conventional instrumentation, the charge-coupled device, for the detection of ECL from the reaction of biogenic amines with the luminescent compound tris(2,2′-bipyridyl)ruthenium(II). Assisted by a 3D-printed light-tight housing, the mobile phone achieved limits of detection of 127, 425 and 421 μM for spermidine, putrescine, and histamine, respectively. The mobile phone’s analytical figures of merit were lesser than the CCD camera but were still within the range to detect contamination. In an exploration of real-world samples, the mobile phone was able to determine the contents of amines in skim milk on par with that of a CCD camera.

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Electrogenerated Chemiluminescent Detection of Polyamines on a Microfluidic Device Using Micromolded Carbon Paste Microelectrodes

Cited by 3 publications

References 42 publications

Recent Advances in Fluorescent Methods for Polyamine Detection and the Polyamine Suppressing Strategy in Tumor Treatment

Recent Advances in Fluorescent Methods for Polyamine Detection and the Polyamine Suppressing Strategy in Tumor Treatment

Polyamines: The Gleam of Next-Generation Plant Growth Regulators for Growth, Development, Stress Mitigation, and Hormonal Crosstalk in Plants—A Systematic Review

Comparison of Mobile Phone and CCD Cameras for Electrochemiluminescent Detection of Biogenic Amines

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