Electrolyte composition of retro‐oil fluid and silicone oil‐related visual loss

Scheerlinck, Laura M E; Kuiper, Jonas J.W.; Liem, Albert T.A.; Schellekens, Peter; Leeuwen, Redmer van

doi:10.1111/aos.12959

Cited by 23 publications

(28 citation statements)

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“…Therefore, the hypothesis of potassium siphoning failure as a mechanism of unexplained visual loss after SO use or removal might in our opinion be a subject of controversy. This is in agreement with Scheerlinck et al [19] , who lately found that potassium and sodium levels were not increased in retro-oil fluid during SO tamponade, while magnesium and chloride levels were significantly lower in retro-oil fluid compared with vitreous humor, and lactate dehydrogenase levels were highly significantly elevated in retro-oil fluid.…”

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confidence: 92%

Silicone Oil-Related Visual Loss

et al. 2017

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Background: Silicone oil (SO) is used as an intravitreal tamponade agent in vitreoretinal surgery for rhegmatogenous retinal detachment (RRD) complicated by proliferative vitreoretinopathy or with large, multiple retinal tears. Usually, SO is left in the eye for at least 3 months. Although its use can lead to well-known complications, intraocular SO is generally well tolerated. Some studies have reported unexpected central vision loss after SO use or removal. Objective: To investigate and analyze the reason for visual loss after the use or removal of intraocular SO in patients who underwent vitrectomy surgeries for RRD. Patients and Methods: A retrospective observational case series of 12 patients with macula-on RRD who reported visual loss after the use or removal of SO was reviewed. Investigations carried out included fundus fluorescein angiography, optical coherence tomography (OCT) of the macula and optic disc, perimetry, and electrophysiological study. Electrolyte levels were measured in retro-oil fluid and compared with their levels in the vitreous humor of patients who underwent vitrectomy for macular holes, floaters, dropped intraocular lenses, or dropped crystalline lens fragments. Results: Visual acuity levels dropped by at least 2 Snellen chart lines. None of the 12 cases had macular detachment at any stage. Fundus fluorescein angiography and OCT results were unremarkable in most of the cases. Mean levels of electrolytes in retro-oil fluids and vitreous humor were similar. Conclusion: Visual loss is a possible complication after SO use or removal. This still remains a mysterious issue which needs further research and investigation.

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confidence: 92%

Silicone Oil-Related Visual Loss

et al. 2017

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“…Once the SO is removed, the K + concentration undergoes sudden changes that activate apoptosis through caspase-3 and caspase-9 pathways [34]. However a recent study found that the potassium levels are not increased in retro-oil fluid during silicone oil tamponade rendering this hypothesis unlikely [37]. …”

Section: Discussionmentioning

confidence: 99%

Un-explained visual loss following silicone oil removal: results of the Pan American Collaborative Retina Study (PACORES) Group

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Berrocal

et al. 2017

Int J Retin Vitr

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PurposeTo report the incidence and clinical features of patients that experienced un-explained visual loss following silicone oil (SO) removal.MethodsMulticenter retrospective study of patients that underwent SO removal during 2000–2012. Visual loss of ≥2 lines was considered significant.ResultsA total of 324 eyes of 324 patients underwent SO removal during the study period. Forty two (13%) eyes suffered a significant visual loss following SO removal. Twenty three (7.1%) of these eyes lost vision secondary to known causes. In the remaining 19 (5.9%) eyes, the loss of vision was not explained by any other pathology. Eleven of these 19 patients (57.9%) were male. The mean age of this group was 49.2 ± 16.4 years. Eyes that had an un-explained visual loss had a mean IOP while the eye was filled with SO of 19.6 ± 6.9 mm Hg. The length of time that the eye was filled with SO was 14.8 ± 4.4 months. In comparison, eyes that did not experience visual loss had a mean IOP of 14 ± 7.3 mm Hg (p < 0.0002) and a mean tamponade duration of 9.3 ± 10.9 months (p < 0.0001).ConclusionsAn un-explained visual loss after SO removal was observed in 5.9% of eyes. Factors associated with this phenomenon included a higher IOP and longer SO tamponade duration.

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“…Previously, we showed that microperimetry is a sensitive test to demonstrate a deep central scotoma in eyes with SORVL (Scheerlinck et al. ,b). We also noted that the central scotoma on microperimetry in SORVL is different from the microperimetry pattern seen in eyes with a macula‐off RRD with similar visual acuity (VA) (Scheerlinck et al.…”

Section: Introductionmentioning

confidence: 90%

“…; Scheerlinck et al. ,b). Silicone oil‐related visual loss (SORVL) is characterized by a profound and irreversible visual loss occurring during SO tamponade or shortly after SO removal, without abnormalities on optical coherence tomography (OCT) or fluorescein angiography (Newsom et al.…”

Section: Introductionmentioning

confidence: 99%