Electrolyte Excretion by Sweat Glands and Kidneys

Body Fluid Balance During Heat Stress in Humans

“…However, many of these studies administered aldosterone just prior to thermal stress, while the latency of action of treatment is more on the order of 18-24 h (196). Subjects given spirolactone, a competitive inhibitor of aldosterone, increase their sweat Naf concentration (46,89,142,156). Davies et al (59) documented an increase in plasma aldosterone levels with heat acclimatization, regardless of the salt balance, and a decrease in sweat "a+].…”

Mechanisms, Instrumentation, Recording Techniques, and Quantification of Responses

“…Additional evidence for a direct effect of salt-active steroids in human sweat glands comes from investigations of ;he competitive aldosterone inhibitor spironolactone, and the increase in Na + concentrations of both thermal (Furman & Beer, 1963;Ladell & Shepherd, 1962;May, 1965) and nonthermal (Collins, 1966) sweat which result from its administration.…”