Electrolyzed Strong Acid Aqueous Solution Irrigation Promotes Wound Healing in a Burn Wound Model

Nakae, Hajime; Inaba, Hideo

doi:10.1046/j.1525-1594.2000.06550.x

Cited by 15 publications

(18 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistently, the microbicidal activities of EOWs were also completely abolished in our study after addition of 20% BSA to the test solutions. Indeed, the rapid inactivation of the anti‐microbial activity following contact with organic matter is the main disadvantage of the application of EOWs (Nakae and Inaba, 2000; Shimmura et al., 2000). Thus, to ensure the efficacy of disinfection procedures using EOW, a thorough pre‐cleaning to minimize the organic load present is essential.…”

Section: Discussionmentioning

confidence: 99%

The Anti‐microbial Activity of Electrolysed Oxidizing Water against Microorganisms relevant in Veterinary Medicine

Fenner

Burge

Kayser

et al. 2006

Journal of Veterinary Medicine, Series B

View full text Add to dashboard Cite

Standards of the German Association of Veterinary Medicine (DVG) for the evaluation of chemical disinfectants were used to assess the anti-microbial efficacy of electrolysed oxidizing water (EOW). Enterococcus faecium, Mycobacterium avium subspecies avium, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans were exposed to anode EOW (pH, 3.0+/-0.1; oxidation-reduction potential (ORP), +1100+/-50 mV; free chlorine, 400+/-20 mg/l Cl2) and combined EOW (7:3 anode:cathode, v/v; pH, 8.3+/-0.1; ORP, 930-950 mV; free chlorine, 271+/-20 mg/l Cl2). In water of standardized hardness (WSH), all bacterial strains were completely inactivated by a 30 min exposure to maximum 10.0% anode EOW (approximately 40.0 mg/l Cl2) or 50.0% combined EOW (approximately 135.5 mg/l Cl2). The sensitivity ranking order for anode EOW to the bacterial test strains was P. mirabilis>S. aureus>M. avium ssp. avium>E. faecium>P. aeruginosa. P. mirabilis and S. aureus decreased to undetectable levels after 5 min of exposure to 7.5% anode EOW (approximately 30.0 mg/l Cl2). Candida albicans was completely inactivated by a 5-min exposure to 5.0% anode EOW. Both, anode and combined EOW exhibited no anti-microbial activities in standardized nutrient broth or after addition of 20.0% bovine serum to the WSH. Further research is necessary to evaluate the efficacy of EOW as a disinfectant under operating conditions in animal production facilities.

show abstract

Section: Discussionmentioning

confidence: 99%

The Anti‐microbial Activity of Electrolysed Oxidizing Water against Microorganisms relevant in Veterinary Medicine

Fenner

Burge

Kayser

et al. 2006

Journal of Veterinary Medicine, Series B

View full text Add to dashboard Cite

show abstract

“…ECAS a treatment significantly improved the survival rates within a rodent in vivo burn wound model infected with P. aeruginosa, along with a reduction in serum endotoxin levels [110]. Moreover, acidic ECAS a have been found to promote re-epithelisation (in an in vivo burn wound model), increasing the proliferation of lymphocytes and macrophages associated with dense collagen deposition [111]. The clinical evidence for the use of ECAS a is largely based on small-scale case studies, but it has shown promise in reducing bacterial infections in burn wounds [112], for the treatment of refractory chronic ulcers [109], as well as synergistic necrotising infections [113], and a neutralised ECAS is now commercially available specifically for the treatment of wounds (Dermacyn, Oculus Innovative Sciences, Petaluma, CA, USA [114]).…”

Section: (I) Treatment and Prevention Of Wound Infectionmentioning

confidence: 97%

Electrochemically activated solutions: evidence for antimicrobial efficacy and applications in healthcare environments

Thorn

Lee

Robinson

et al. 2011

Eur J Clin Microbiol Infect Dis

107

View full text Add to dashboard Cite

Due to the limitations associated with the use of existing biocidal agents, there is a need to explore new methods of disinfection to help maintain effective bioburden control, especially within the healthcare environment. The transformation of low mineral salt solutions into an activated metastable state, by electrochemical unipolar action, produces a solution containing a variety of oxidants, including hypochlorous acid, free chlorine and free radicals, known to possess antimicrobial properties. Electrochemically activated solutions (ECAS) have been shown to have broad-spectrum antimicrobial activity, and have the potential to be widely adopted within the healthcare environment due to low-cost raw material requirements and ease of production (either remotely or in situ). Numerous studies have found ECAS to be highly efficacious, as both a novel environmental decontaminant and a topical treatment agent (with low accompanying toxicity), but they are still not in widespread use, particularly within the healthcare environment. This review provides an overview of the scientific evidence for the mode of action, antimicrobial spectrum and potential healthcare-related applications of ECAS, providing an insight into these novel yet seldom utilised biocides.

show abstract

“…Five commonly used topical agents are 5% mafenide acetate, 10% povidone with 1% free iodine, 0.25% sodium hypochlorite, 3% hydrogen peroxide, and 0.25% acetic acid [25]. In addition, hyaluronic acid was used for wound dressing [26]. Basically, modulation of nutrition, underlining medical problems (such as vascular and neural diseases, diabetes, and infection), acidity of wounds, host immunity, cytokines, NO, or prostaglandins have a great impact on wound healing process.…”

Section: Pathophysiology Of Wound Healingmentioning

confidence: 99%

Honey for Wound Healing, Ulcers, and Burns; Data Supporting Its Use in Clinical Practice

Al-Waili

Salom²,

Al-Ghamdi

2011

The Scientific World JOURNAL

249

193

View full text Add to dashboard Cite

The widespread existence of unhealed wounds, ulcers, and burns has a great impact on public health and economy. Many interventions, including new medications and technologies, are being used to help achieve significant wound healing and to eliminate infections. Therefore, to find an intervention that has both therapeutic effect on the healing process and the ability to kill microbes is of great value. Honey is a natural product that has been recently introduced in modern medical practice. Honey's antibacterial properties and its effects on wound healing have been thoroughly investigated. Laboratory studies and clinical trials have shown that honey is an effective broad-spectrum antibacterial agent. This paper reviews data that support the effectiveness of natural honey in wound healing and its ability to sterilize infected wounds. Studies on the therapeutic effects of honey collected in different geographical areas on skin wounds, skin and gastric ulcers, and burns are reviewed and mechanisms of action are discussed. (Ulcers and burns are included as an example of challenging wounds.) The data show that the wound healing properties of honey include stimulation of tissue growth, enhanced epithelialization, and minimized scar formation. These effects are ascribed to honey's acidity, hydrogen peroxide content, osmotic effect, nutritional and antioxidant contents, stimulation of immunity, and to unidentified compounds. Prostaglandins and nitric oxide play a major role in inflammation, microbial killing, and the healing process. Honey was found to lower prostaglandin levels and elevate nitric oxide end products. These properties might help to explain some biological and therapeutic properties of honey, particularly as an antibacterial agent or wound healer. The data presented here demonstrate that honeys from different geographical areas have considerable therapeutic effects on chronic wounds, ulcers, and burns. The results encourage the use of honey in clinical practice as a natural and safe wound healer.

show abstract

Electrolyzed Strong Acid Aqueous Solution Irrigation Promotes Wound Healing in a Burn Wound Model

Cited by 15 publications

References 9 publications

The Anti‐microbial Activity of Electrolysed Oxidizing Water against Microorganisms relevant in Veterinary Medicine

The Anti‐microbial Activity of Electrolysed Oxidizing Water against Microorganisms relevant in Veterinary Medicine

Electrochemically activated solutions: evidence for antimicrobial efficacy and applications in healthcare environments

Honey for Wound Healing, Ulcers, and Burns; Data Supporting Its Use in Clinical Practice

Contact Info

Product

Resources

About