Abstract. The forthcoming space missions aiming at developing new habits on the Moon and into deep space are opening new challenges for materials scientists in enabling in-situ efficient systems and subsystems. During the last decades, Space Agencies programs of long-term missions addressed to the future Moon colonization moved the aerospace research interest toward the knowledge of how the lunar conditions could represent scientific and technological tasks to be tackled, to deal with such a big challenge. Among very many matters, a still open question is to understand how proper the lunar environment would be for TLC systems daily used on Earth, or whether it should be necessary to establish different stable systems on the Moon by finding alternative solutions with respect to the Earth conventional technologies. This paper introduces the scientific activity developed during recent years at the Aerospace Systems Laboratory of Sapienza University of Rome, concerning the study of lunar regolith with focus on its effect on the microwave fields propagation. The research addresses such task by simulating several representative Moon environmental conditions, reproducing well defined chemical/physical background in terms of atmospheric parameters and soil compositions, as from the available literature data, and analyzing the microwave propagation characteristics to design efficiently mobile TLC systems operating on the Moon. With the further objective of considering regolith as main routine resource for drawing up systems and facilities constituting lunar living structures, the analysis of regolith-microwave interaction is thus focused on two specific paths, such as building airtight structures by means of ISRU methodologies and the EM compatibility (EMC) analysis of simulated lunar environment & TLC systems design. This work can be thus considered as linked to the forthcoming projects aimed at enhancing the research community knowledge about the Moon environment, by assessing scientific background and establishing technological processes for lunar TLC systems development.