Electromagnetic Breast Imaging: Average Tissue Property Values in Women with Negative Clinical Findings

Poplack, Steven P.; Paulsen, Keith D.; Hartov, Alex; Meaney, Paul M.; Pogue, Brian W.; Tosteson, Tor D.; Grove, Margaret R.; Soho, Sandra; Wells, Wendy A.

doi:10.1148/radiol.2312030606

Cited by 113 publications

(80 citation statements)

References 32 publications

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“…Adding alternative imaging modalities, particularly modalities providing functional assessment of tissues, to structural x-ray imaging could provide improvement for cancer diagnosis. In particular, functional imaging by means of diffuse optical tomography (DOT) has shown great promise in this respect (11)(12)(13)(14)(15)(16).…”

Section: Imaging Instrumentationmentioning

confidence: 99%

Combined Optical and X-ray Tomosynthesis Breast Imaging

Fang¹,

Selb²,

Carp³

et al. 2011

Radiology

196

176

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Purpose:To explore the optical and physiologic properties of normal and lesion-bearing breasts by using a combined optical and digital breast tomosynthesis (DBT) imaging system. Materials and Methods:Institutional review board approval and patient informed consent were obtained for this HIPAA-compliant study. Combined optical and tomosynthesis imaging analysis was performed in 189 breasts from 125 subjects (mean age, 56 years 6 13 [standard deviation]), including 138 breasts with negative fi ndings and 51 breasts with lesions. Threedimensional (3D) maps of total hemoglobin concentration (Hb T ), oxygen saturation (S O 2 ), and tissue reduced scattering coeffi cients were interpreted by using the coregistered DBT images. Paired and unpaired t tests were performed between various tissue types to identify signifi cant differences. Results:The estimated average bulk Hb T from 138 normal breasts was 19.2 m mol/L. The corresponding mean SO 2 was 0.73, within the range of values in the literature. A linear correlation ( R = 0.57, P , .0001) was found between Hb T and the fi broglandular volume fraction derived from the 3D DBT scans. Optical reconstructions of normal breasts revealed structures corresponding to chest-wall muscle, fi broglandular, and adipose tissues in the Hb T , SO 2 , and scattering images. In 26 malignant tumors of 0.6-2.5 cm in size, Hb T was signifi cantly greater than that in the fibroglandular tissue of the same breast ( P = .0062). Solid benign lesions ( n = 17) and cysts ( n = 8) had signifi cantly lower Hb T contrast than did the malignant lesions ( P = .025 and P = .0033, respectively). Conclusion:The optical and DBT images were structurally consistent. The malignant tumors and benign lesions demonstrated different Hb T and scattering contrasts, which can potentially be exploited to reduce the false-positive rate of conventional mammography and unnecessary biopsies. BREAST IMAGING: Combined Optical and X-ray Tomosynthesis Breast Imaging Fang et al cancers and the reduction of the number of biopsies of benign lesions, compared with stand-alone conventional mammography.Our purpose was to explore the optical and physiologic properties of normal and lesion-bearing breasts by using a combined optical and DBT imaging system. Materials and MethodsThe experimental protocols were approved by the institutional review board (Massachusetts General Hospital), and written informed consent was obtained from all subjects. The study was compliant with Health Insurance Portability and Accountability Act guidelines. Imaging InstrumentationA photograph of the combined optical and DBT imaging system and probes is shown in Figures E1 and E2 (online). The detailed confi guration of the imaging physiologic parameters, such as the concentrations of oxygenated hemoglobin (Hb O ), deoxygenated hemoglobin (Hb R ), water, and lipids ( 16 ). With DOT, nearinfrared lasers, either radiofrequencymodulated, continuous-wave or pulsed, are used to probe tissue structure noninvasively ( 13,17 ). The concentrations of the tissue ...

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Section: Imaging Instrumentationmentioning

confidence: 99%

Combined Optical and X-ray Tomosynthesis Breast Imaging

Fang¹,

Selb²,

Carp³

et al. 2011

Radiology

196

176

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“…Recent studies have used scattering to study structural variations. For example, Poplack et al 38 showed in a normal cohort of 23 women that there is a significant decrease in the reduced scattering coefficient ͑ s Ј͒ at 785 nm with increasing body mass index and that adipose tissue was less scattering than glandular tissue, as expected. The same trend was observed by Durduran et al 29 in a subject pool of 52 volunteers.…”

Section: Discussionmentioning

confidence: 65%

Three Dimensional Reconstruction Algorithm for Imaging Pathophysiological Signals Within Breast Tissue Using Near Infrared Light

Dehghani¹

2006

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE (DD-MM-YYYY) 01-07-2005 REPORT TYPE Annual Summary DATES COVERED (From -To PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERDartmouth College Hanover, NH 03755 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel CommandFort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTOptical tomography is a non-invasive imaging technique that can image properties of biological tissue using Near Infrared light. Under this program, this technique has been used to characterize breast tissue in healthy volunteers as well as detecting tumor in patients. Image reconstruction models and algorithms have been developed, under this program, which incorporates inherent wavelength dependant a-priori information (spectral) as well as concurrently measured MRI structural information (spatial) to show that the quantitative and qualitative accuracy can be dramatically improved. Three dimensional models have been developed that will allow the use of correct size and shape of the breast being imaged showing that image artifacts can be eliminated by the correct assumptions about the model of the breast. Novel models have also been developed that will account for otherwise ignored Refractive Index (RI) distribution of breast tissue, and the results indicate that providing the RI distribution of breast tissue is not extremely heterogeneous, the impact on reconstructed artifacts is minimal. Conclusions…………………………………………………………………………..7 SUBJECT TERMS References……………………………………………………………………………7 Appendices……………………………………………………………………………9Introduction In this work, a novel imaging technique is explored that uses non-harmful application of near infrared light to determine the pathophysiological properties of breast tissue. Using this technique, known as near infrared (NIR) tomography, an optical fiber placed on the surface of the region of interest, the breast, delivers an input signal while other optical ...

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“…Similar results were also reported 28 for a 3 days tumor inoculated rat with 1064 nm PAT system. On the other hand, since early tumor development is always accompanied by higher water content and induced larger local conductivity, 29 the tumor is notably detected in TAT image [ Fig. 2(c)].…”

Section: Resultsmentioning

confidence: 99%

In vivo tumor detection with combined MR–Photoacoustic-Thermoacoustic imaging

Huang

Cai

Zhao

et al. 2016

J. Innov. Opt. Health Sci.

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Here, we report a new method using combined magnetic resonance (MR)-Photoacoustic (PA)-Thermoacoustic (TA) imaging techniques, and demonstrate its unique ability for in vivo cancer detection using tumor-bearing mice. Circular scanning TA and PA imaging systems were used to recover the dielectric and optical property distributions of three colon carcinoma bearing mice While a 7.0-T magnetic resonance imaging (MRI) unit with a mouse body volume coil was utilized for high resolution structural imaging of the same mice. Three plastic tubes¯lled with soybean sauce were used as¯ducial markers for the co-registration of MR, PA and TA images. The resulting fused images provided both enhanced tumor margin and contrast relative to the surrounding normal tissues. In particular, some¯nger-like protrusions extending into the surrounding tissues were revealed in the MR/TA infused images. These results show that the tissue functional optical and dielectric properties provided by PA and TA images along with the anatomical structure by MRI in one picture make accurate tumor identi¯cation easier. This combined MR-PA-TA-imaging strategy has the potential to o®er a clinically useful triplemodality tool for accurate cancer detection and for intraoperative surgical navigation.

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Electromagnetic Breast Imaging: Average Tissue Property Values in Women with Negative Clinical Findings

Cited by 113 publications

References 32 publications

Combined Optical and X-ray Tomosynthesis Breast Imaging

Combined Optical and X-ray Tomosynthesis Breast Imaging

Three Dimensional Reconstruction Algorithm for Imaging Pathophysiological Signals Within Breast Tissue Using Near Infrared Light

In vivo tumor detection with combined MR–Photoacoustic-Thermoacoustic imaging

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