Electromagnetic field (10 Hz, 1 mT) protects mesenchymal stem cells from oxygen-glucose deprivation-induced cell death by reducing intracellular Ca&lt;sup&gt;2+&lt;/sup&gt; and reactive oxygen species

Jung, Jae-Chul; Kim, Jae Young

doi:10.1016/j.jab.2016.11.003

Cited by 2 publications

(2 citation statements)

References 60 publications

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“…In a similar experiment, ELF-MF (50 Hz/1 mT) increased cell viability and decreased intracellular ROS/RNS in mesenchymal stem cells submitted to OGD conditions and 3 h ELF-MF exposure (Jung and Kim, 2017). The other combinations (10 Hz/0.01 mT, 10 Hz/0.1 mT, and 100 Hz/1 mT) did not show any protective effect.…”

Section: Sinusoidal Electromagnetic Field: In Vitro and In Vivo Experimentsmentioning

confidence: 75%

“…Electromagnetic field homogeneity is another parameter to be analyzed in order to define the best approach. Among the examined articles, only four authors used a homogenous magnetic field (Rauš et al, 2014;Duong and Kim, 2016;Segal et al, 2016;Jung and Kim, 2017). This approach guarantees the same magnetic induction in all work surfaces but such induction changes once the electromagnetic field interacts with the sample.…”

Section: Discussionmentioning

confidence: 99%

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Electromagnetic Field as a Treatment for Cerebral Ischemic Stroke

Gomez

Font

Brône

et al. 2021

Front. Mol. Biosci.

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Cerebral stroke is a leading cause of death and adult-acquired disability worldwide. To this date, treatment options are limited; hence, the search for new therapeutic approaches continues. Electromagnetic fields (EMFs) affect a wide variety of biological processes and accumulating evidence shows their potential as a treatment for ischemic stroke. Based on their characteristics, they can be divided into stationary, pulsed, and sinusoidal EMF. The aim of this review is to provide an extensive literature overview ranging from in vitro to even clinical studies within the field of ischemic stroke of all EMF types. A thorough comparison between EMF types and their effects is provided, as well as an overview of the signal pathways activated in cell types relevant for ischemic stroke such as neurons, microglia, astrocytes, and endothelial cells. We also discuss which steps have to be taken to improve their therapeutic efficacy in the frame of the clinical translation of this promising therapy.

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Section: Sinusoidal Electromagnetic Field: In Vitro and In Vivo Experimentsmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Electromagnetic Field as a Treatment for Cerebral Ischemic Stroke

Gomez

Font

Brône

et al. 2021

Front. Mol. Biosci.

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Magnetic field in the extreme low frequency band protects neuronal and microglia cells from oxygen-glucose deprivation

Mata,

Calovi,

Benli

et al. 2024

Front. Cell. Neurosci.

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Ischemic stroke consists of rapid neural death as a consequence of brain vessel obstruction, followed by damage to the neighboring tissue known as ischemic penumbra. The cerebral tissue in the core of the lesions becomes irreversibly damaged, however, the ischemic penumbra is potentially recoverable during the initial phases after the stroke. Therefore, there is real need for emerging therapeutic strategies to reduce ischemic damage and its spread to the penumbral region. For this reason, we tested the effect of Extreme Low Frequency Electromagnetic Stimulation (ELF-EMS) on in vitro primary neuronal and microglial cultures under oxygen-glucose deprivation (OGD) conditions. ELF-EMS under basal non-OGD conditions did not induce any effect in cell survival. However, ELF-EMS significantly reduced neuronal cell death in OGD conditions and reduced ischemic induced Ca2+ overload. Likewise, ELF-EMS modulated microglia activation and OGD-induced microglia cell death. Hence, this study suggests potential benefits in the application of ELF-EMS to limit ischemic irreversible damages under in vitro stroke conditions, encouraging in vivo preclinical validations of ELF-EMS as a potential therapeutic strategy for ischemic stroke.

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Electromagnetic field (10 Hz, 1 mT) protects mesenchymal stem cells from oxygen-glucose deprivation-induced cell death by reducing intracellular Ca<sup>2+</sup> and reactive oxygen species

Cited by 2 publications

References 60 publications

Electromagnetic Field as a Treatment for Cerebral Ischemic Stroke

Electromagnetic Field as a Treatment for Cerebral Ischemic Stroke

Magnetic field in the extreme low frequency band protects neuronal and microglia cells from oxygen-glucose deprivation

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