Electromagnetic field and TGF-β enhance the compensatory plasticity after sensory nerve injury in cockroach Periplaneta americana

Jankowska, Milena; Klimek, Angelika; Valsecchi, Chiara; Stankiewicz, Maria; Wyszkowska, Joanna; Rogalska, Justyna

doi:10.1038/s41598-021-85341-z

Cited by 2 publications

(2 citation statements)

References 46 publications

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“…Both peripheral ( Eccles et al, 1963 ; Jankowska et al, 2021 ) and central ( Carpenter et al, 1963 ; Andersen et al, 1964 ; Fetz, 1968 ) mechanisms have been shown to contribute to regulate Ia sensory transmission. GABAergic neurons contributing to regulate Ia sensory transmission receive innervation from the brain and spinal cord ( Rudomin and Schmidt, 1999 ).…”

Section: Discussionmentioning

confidence: 99%

Altered regulation of Ia afferent input during voluntary contraction in humans with spinal cord injury

Chen

Perez

2022

eLife

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Sensory input converging on the spinal cord contributes to the control of movement. Although sensory pathways reorganize following spinal cord injury (SCI), the extent to which sensory input from Ia afferents is regulated during voluntary contraction after the injury remains largely unknown. To address this question, the soleus H-reflex and conditioning of the H-reflex by stimulating homonymous [depression of the soleus H-reflex evoked by common peroneal nerve (CPN) stimulation, D1 inhibition] and heteronymous (d), [monosynaptic Ia facilitation of the soleus H-reflex evoked by femoral nerve stimulation (FN facilitation)] nerves were tested at rest, and during tonic voluntary contraction in humans with and without chronic incomplete SCI. The soleus H-reflex size increased in both groups during voluntary contraction compared with rest, but to a lesser extent in SCI participants. Compared with rest, the D1 inhibition decreased during voluntary contraction in controls but it was still present in SCI participants. Further, the FN facilitation increased in controls but remained unchanged in SCI participants during voluntary contraction compared with rest. Changes in the D1 inhibition and FN facilitation were correlated with changes in the H-reflex during voluntary contraction, suggesting an association between outcomes. These findings provide the first demonstration that the regulation of Ia afferent input from homonymous and heteronymous nerves is altered during voluntary contraction in humans with SCI, resulting in lesser facilitatory effect on motor neurons.

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Section: Discussionmentioning

confidence: 99%

Altered regulation of Ia afferent input during voluntary contraction in humans with spinal cord injury

Chen

Perez

2022

eLife

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“…Both peripheral 35,36 and central 37-39 mechanisms have been shown to contribute to regulate Ia sensory transmission. GABAergic neurons contributing to regulate Ia sensory transmission receive innervation from the brain and spinal cord 13 .…”

Section: Discussionmentioning

confidence: 99%

Altered Regulation of Ia Afferent Input during Voluntary Activity after Human Spinal Cord Injury

Chen

Perez

2022

Preprint

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Sensory input converging on the spinal cord contributes to the control of voluntary activity. Although sensory pathways reorganize following spinal cord injury (SCI), the extent to which sensory input from Ia afferents is regulated during voluntary activity after the injury remains largely unknown. To address this question, we examined the soleus H-reflex and conditioning of the H-reflex by stimulating homonymous and heteronymous nerves [depression of the soleus H-reflex evoked by common peroneal nerve stimulation (D1 inhibition) and the monosynaptic Ia facilitation of the soleus H-reflex evoked by femoral nerve stimulation (FN facilitation)] at rest, and during tonic voluntary activity in humans with and without chronic incomplete SCI. We found that during voluntary activity the soleus H-reflex size increased in both groups compared with rest, but to a lesser extent in SCI participants. Compared with rest, the D1 inhibition decreased during voluntary activity in controls but it was still present in SCI participants. Further, the FN facilitation increased in controls but remained unchanged in SCI participants during voluntary activity compared with rest. Changes in the D1 inhibition and FN facilitation were correlated with changes in the H-reflex during voluntary activity, suggesting an association between outcomes. These findings provide the first demonstration that the regulation of Ia afferent input from homonymous and heteronymous nerves is altered during voluntary in humans with SCI, resulting in lesser facilitatory effect on motor neurons.

show abstract

Electromagnetic field and TGF-β enhance the compensatory plasticity after sensory nerve injury in cockroach Periplaneta americana

Cited by 2 publications

References 46 publications

Altered regulation of Ia afferent input during voluntary contraction in humans with spinal cord injury

Altered regulation of Ia afferent input during voluntary contraction in humans with spinal cord injury

Altered Regulation of Ia Afferent Input during Voluntary Activity after Human Spinal Cord Injury

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