Electromagnetic field exposure as a plausible approach to enhance the proliferation and differentiation of mesenchymal stem cells in clinically relevant scenarios

Hamid, Haslinda Abdul; Sarmadi, Vahid Hosseinpour; Prasad, Vivek; Ramasamy, Rajesh; Miskon, Azizi

doi:10.1631/jzus.b2100443

Cited by 18 publications

(26 citation statements)

References 133 publications

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“…In addition to the previously mentioned biochemical stimuli, physical stimuli such as electromagnetic fields (EMF), microgravity (MG), fluid shear stress (FSS), and hydrostatic pressure (HP) could also have an impact on the proliferation and differentiation of MSCs (Table 3 ). EMF, a non-invasive biophysical therapy, is a combination of electric and magnetic fields and has been widely used in the treatment of bone diseases[ 38 , 39 ]. Exposure to sinusoidal EMF (1mT,15Hz,4h/d) promoted the proliferation and osteogenic and chondrogenic differentiation of BMSCs[ 40 ].…”

Section: Physical Stimulimentioning

confidence: 99%

Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells

Zhou¹,

Wan²,

Wang³

et al. 2023

World J Stem Cells

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Mesenchymal stem cells (MSCs), distributed in many tissues in the human body, are multipotent cells capable of differentiating in specific directions. It is usually considered that the differentiation process of MSCs depends on specialized external stimulating factors, including cell signaling pathways, cytokines, and other physical stimuli. Recent findings have revealed other underrated roles in the differentiation process of MSCs, such as material morphology and exosomes. Although relevant achievements have substantially advanced the applicability of MSCs, some of these regulatory mechanisms still need to be better understood. Moreover, limitations such as long-term survival in vivo hinder the clinical application of MSCs therapy. This review article summarizes current knowledge regarding the differentiation patterns of MSCs under specific stimulating factors.

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Section: Physical Stimulimentioning

confidence: 99%

Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells

Zhou¹,

Wan²,

Wang³

et al. 2023

World J Stem Cells

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“…Using the human bone marrow-derived MSCs, our group confirmed that EMFs significantly promoted cell migration by activating intracellular Ca 2+ -dependent FAK/Rho GTPase migratory signalling [ 72 ]. Additionally, higher proliferation rate of MSCs resulted from EMFs’ stimulation is well-determined and has been widely demonstrated [ 73 – 75 ]. Therefore, after EMFs’ application, MSCs loaded on bone tissue engineering scaffolds would give rise to enhanced cell proliferation and migration, both of which are beneficial for bone regeneration.…”

Section: Biological Effects Of Emfs In Bone Tissue Engineering Applic...mentioning

confidence: 99%

Harnessing electromagnetic fields to assist bone tissue engineering

Zhao

Liu

et al. 2023

Stem Cell Res Ther

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Bone tissue engineering (BTE) emerged as one of the exceptional means for bone defects owing to it providing mechanical supports to guide bone tissue regeneration. Great advances have been made to facilitate the success of BTE in regenerating bone within defects. The use of externally applied fields has been regarded as an alternative strategy for BTE. Electromagnetic fields (EMFs), known as a simple and non-invasive therapy, can remotely provide electric and magnetic stimulation to cells and biomaterials, thus applying EMFs to assist BTE would be a promising strategy for bone regeneration. When combined with BTE, EMFs improve cell adhesion to the material surface by promoting protein adsorption. Additionally, EMFs have positive effects on mesenchymal stem cells and show capabilities of pro-angiogenesis and macrophage polarization manipulation. These advantages of EMFs indicate that it is perfectly suitable for representing the adjuvant treatment of BTE. We also summarize studies concerning combinations of EMFs and diverse biomaterial types. The strategy of combining EMFs and BTE receives encouraging outcomes and holds a promising future for effectively treating bone defects.

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“…Even though freshly isolated MSCs have numerous positive attributes, they are extremely heterogeneous and come in limited quantities, owing to the patients age and gender (Hamid et al, 2022). As such, the development of novel methods for cell expansion is a critical step towards translation into clinics.…”

Section: Electromagnetic Fieldsmentioning

confidence: 99%

Mesenchymal stem cell therapy for neurological disorders: The light or the dark side of the force?

Isakovic

Šerer

Barišić

et al. 2023

Front. Bioeng. Biotechnol.

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Neurological disorders are recognized as major causes of death and disability worldwide. Because of this, they represent one of the largest public health challenges. With awareness of the massive burden associated with these disorders, came the recognition that treatment options were disproportionately scarce and, oftentimes, ineffective. To address these problems, modern research is increasingly looking into novel, more effective methods to treat neurological patients; one of which is cell-based therapies. In this review, we present a critical analysis of the features, challenges, and prospects of one of the stem cell types that can be employed to treat numerous neurological disorders—mesenchymal stem cells (MSCs). Despite the fact that several studies have already established the safety of MSC-based treatment approaches, there are still some reservations within the field regarding their immunocompatibility, heterogeneity, stemness stability, and a range of adverse effects—one of which is their tumor-promoting ability. We additionally examine MSCs’ mechanisms of action with respect to in vitro and in vivo research as well as detail the findings of past and ongoing clinical trials for Parkinson’s and Alzheimer’s disease, ischemic stroke, glioblastoma multiforme, and multiple sclerosis. Finally, this review discusses prospects for MSC-based therapeutics in the form of biomaterials, as well as the use of electromagnetic fields to enhance MSCs’ proliferation and differentiation into neuronal cells.

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Electromagnetic field exposure as a plausible approach to enhance the proliferation and differentiation of mesenchymal stem cells in clinically relevant scenarios

Cited by 18 publications

References 133 publications

Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells

Stimulating factors for regulation of osteogenic and chondrogenic differentiation of mesenchymal stem cells

Harnessing electromagnetic fields to assist bone tissue engineering

Mesenchymal stem cell therapy for neurological disorders: The light or the dark side of the force?

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