Electromagnetic fields enhance the stress response at elevated temperatures in the nematodeCaenorhabditis elegans

Junkersdorf, Bernd; Bauer, H.‐D.; Gutzeit, Herwig O.

doi:10.1002/(sici)1521-186x(200002)21:2<100::aid-bem4>3.0.co;2-u

Cited by 60 publications

(40 citation statements)

References 23 publications

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“…Other recent studies have shown a stress response in C. elegans due to exposure to extremely low frequency (ELF -50/60 Hz) magnetic fields, which may also have been owing to interactions with biogenic magnetite (Junkersdorf et al 2000;Miyakawa et al 2001). Both of these sets of results are consistent with ferromagnetic transduction via biogenic magnetite and may need to be re-evaluated in light of the discovery of biogenic magnetite in C. elegans.…”

Section: Discussionmentioning

confidence: 77%

Biogenic magnetite in the nematode Caenorhabditis elegans

Cranfield

Dawe

Karloukovski

et al. 2004

Proc. R. Soc. Lond. B

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The nematode Caenorhabditis elegans is widely used as a model system in biological research. Recently, examination of the production of heatshock proteins in this organism in response to mobile phone-type electromagnetic f ield exposure produced the most robust demonstration to date of a non-thermal, deleterious biological effect. Though these results appear to be a sound demonstration of non-thermal bioeffects, to our knowledge, no mechanism has been proposed to explain them. We show, apparently for the f irst time, that biogenic magnetite, a ferrimagnetic iron oxide, is present in C. elegans. Its presence may have confounding effects on experiments involving electromagnetic f ields as well as implications for the use of this nematode as a model system for iron biomineralization in multicellular organisms.

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Section: Discussionmentioning

confidence: 77%

Biogenic magnetite in the nematode Caenorhabditis elegans

Cranfield

Dawe

Karloukovski

et al. 2004

Proc. R. Soc. Lond. B

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“…It has been suggested that sensitization might be a prerequisite for biological effects of electromagnetic fields to be observed, or that a co-stress enhances the power-frequency magnetic-field effect (22,23). It was for this reason that whole blood rather than isolated leukocytes was used in this study, since the separation of leukocytes from blood by differential centrifugation might elicit physical stress on the isolated cells.…”

Section: Resultsmentioning

confidence: 99%

Effect of 50 Hz Electromagnetic Fields on the Induction of Heat-Shock Protein Gene Expression in Human Leukocytes

et al. 2004

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Although evidence is controversial, exposure to environmental power-frequency magnetic fields is of public concern. Cells respond to some abnormal physiological conditions by producing cytoprotective heat-shock (or stress) proteins. In this study, we determined whether exposure to power-frequency magnetic fields in the range 0-100 T rms either alone or concomitant with mild heating induced heat-shock protein gene expression in human leukocytes, and we compared this response to that induced by heat alone. Samples of human peripheral blood were simultaneously exposed to a range of magnetic-field amplitudes using a regimen that was designed to allow field effects to be distinguished from possible artifacts due to the position of the samples in the exposure system. Power-frequency magnetic-field exposure for 4 h at 37؇C had no detectable effect on expression of the genes encoding HSP27, HSP70A or HSP70B, as determined using reverse transcriptase-PCR, whereas 2 h at 42؇C elicited 10-, 5-and 12-fold increases, respectively, in the expression of these genes. Gene expression in cells exposed to power-frequency magnetic fields at 40؇C was not increased compared to cells incubated at 40؇C without field exposure. These findings and the extant literature suggest that power-frequency electromagnetic fields are not a universal stressor, in contrast to physical agents such as heat. ᭧

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“…Miyakawa et al [2001] found that the temperature required for a given expression of a reporter gene (lacZ) under HSP16 promoter control in transgenic nematode worms was reduced after exposure to a 60 Hz magnetic field at up to 0.5 T. Leszczynski et al [2002] saw an increase in protein phosphorylation and Hsp27 expression after exposure to a 900 MHz GSM signal. Other reports, discussed previously, have found magnetic field influences on Hsp16 activity in nematodes [Junkersdorf et al, 2000], as well as Hsp27 in cell cultures [Pipkin et al, 1999;Tokalov and Gutzeit, 2004]. Controversy exists for studies of HSP27 as well, and no effect was seen in several papers [Guisasola et al, 2002;Shi et al, 2003;Coulton et al, 2004;Lim et al, 2005].…”

Section: Mechanisms: Heat Shock Proteinsmentioning

confidence: 93%

The influence of extremely low frequency magnetic fields on cytoprotection and repair

Robertson

Thomas

Bureau

et al. 2006

Bioelectromagnetics

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Ischemia-reperfusion injuries, such as those suffered from various types of cardiovascular disease, are major causes of death and disability. For relatively short periods of ischemia, much of the damage is potentially reversible and in fact, does not occur until the influx of oxygen during the reperfusion stage. Because of this, there is a window of opportunity to protect the ischemic tissue. Here, we review several mechanisms of protection, such as heat shock proteins, opioids, collateral blood flow, and nitric oxide induction, and the evidence indicating that magnetic fields may be used as a means of providing protection via each of these mechanisms. While there are few studies demonstrating direct protection with magnetic field therapies, there are a number of published reports indicating that electromagnetic fields may be able to influence some of the biochemical systems with protective applications.

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Electromagnetic fields enhance the stress response at elevated temperatures in the nematodeCaenorhabditis elegans

Cited by 60 publications

References 23 publications

Biogenic magnetite in the nematode Caenorhabditis elegans

Biogenic magnetite in the nematode Caenorhabditis elegans

Effect of 50 Hz Electromagnetic Fields on the Induction of Heat-Shock Protein Gene Expression in Human Leukocytes

The influence of extremely low frequency magnetic fields on cytoprotection and repair

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