We investigate the QCD topological susceptibility χt by using the nonlocal chiral quark model (NLχQM). This model is based on the liquid instanton QCD-vacuum configuration in which SU(3) flavor symmetry is explicitly broken by the current quark mass (m u,d , ms) ≈ (5, 135) MeV. To compute χt, the local topological charge density operator Qt(x) is derived from the effective partition function of NLχQM. We take into account the contributions from the leading-order (LO) ones ∼ O(Nc) in the 1 Nc expansion. We also verify that the analytical expression of χt in NLχQM satisfy the Witten-Veneziano (WV) and the Leutwyler-Smilga (LS) formulae. Once the average instanton size and inter-instanton distance are fixed withρ = 1 3 fm andR = 1 fm, respectively, all the associated model parameters are all determined self-consistently within the model, including the η and η ′ weak decay constants. We obtain the results such as Fη = 96.77 MeV and F η ′ = 102.53 MeV for instance. Numerically we observe that χt = (165.57 MeV) 4 in our full calculation. This value is comparable with its empirical one χt = (175 ± 5 MeV)4 . We also find that our χ (194.30, MeV) 4 in the quenched limit and χ LS t = (162.54 MeV) 4 in the chiral limit. Consequently, we conclude that χt < χ QL t . Our result also implies that the (10 ∼ 20) % decrease with the dynamical quark contributions.