Abstract-A compact tri-band slot antenna based on a mesh-grid structure, which is suitable for WLAN/WiMAX applications, is presented. The proposed antenna is optimized by a Boolean differential evolution algorithm (BDE). Then an experimental prototype is fabricated and measured. Results of simulation and measurements indicate that the proposed antenna has |S 11 | < −10 dB in the three chosen frequency bands from 2.35 to 2.85 GHz, from 3.1 to 4.4 GHz and from 4.8 GHz to 5.85 GHz, which covers WLAN bands (2.4/5.2/5.8 GHz) and the WiMAX bands (2.5/3.5/5.5 GHz), respectively.In addition, good radiation performances such as omnidirectional and doughnut-shaped directivity and reasonable gain over the operating bands have been obtained.This example also demonstrates the applicability of the BDE/MOM optimization algorithm to efficient and in potential automated method for the antenna design.