Electromagnetic non-polarized symmetric hybrid wave propagation in nonlinear media with saturation

Yu., Kurseeva V.

doi:10.1109/dd.2018.8553516

Cited by 1 publication

(1 citation statement)

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“…The triphenylethylene core is constructed via the McMurry coupling reaction using substituted benzophenones and propiophenone. 51 E-isomer of 25 is isolated in acetone-hexane system as the major product (E/Z ratio: 6:1) with a 72% yield and confirmed by NOE NMR experiment. Nitro group was also reduced directly under the reducing environment with zinc powder.…”

Section: Synthesis Of Compound 9 Analogsmentioning

confidence: 69%

Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors

Cooper

Schafer

et al. 2020

J. Med. Chem.

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Filoviridae, including Ebola (EBOV) and Marburg (MARV) viruses, are emerging pathogens that pose a serious threat to public health. No agents have been approved to treat filovirus infections, representing a major unmet medical need. The selective estrogen receptor modulator (SERM) toremifene was previously identified from a screen of FDA-approved drugs as a potent EBOV viral entry inhibitor, via binding to EBOV glycoprotein (GP). A focused screen of ER ligands identified ridaifen-B as a potent dual inhibitor of EBOV and MARV. Optimization and reverseengineering to remove ER activity led to a novel compound 30 showing potent inhibition against infectious EBOV Zaire (0.09 μM) and MARV (0.64 μM). Mutagenesis studies confirmed that inhibition of EBOV viral entry is mediated by direct interaction with GP. Importantly, compound 30 (XL-147) displayed broad-spectrum anti-filovirus activity against Bundibugyo, Tai Forest, Reston, and Měnglà viruses, and is the first sub-micromolar antiviral agent reported for some of these strains, therefore warranting further development as a pan-filovirus inhibitor.

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Section: Synthesis Of Compound 9 Analogsmentioning

confidence: 69%