Astrophysical observations suggest that most of the matter in the cosmos consists of a new form that has not been observed on Earth. The nature and origin of this mysterious dark matter are among the most pressing questions in fundamental science. In this review we summarize the current state of dark matter research from two perspectives. First, we provide an overview of the leading theoretical proposals for dark matter. And second, we describe how these proposals have driven a broad and diverse global search program for dark matter involving direct laboratory searches and astrophysical observations. This review is based on a Green Paper on dark matter prepared as part of the 2020 Astroparticle Community Planning initiative undertaken by the Canadian Subatomic Physics community but has been significantly updated to reflect recent advances.