56 patients with large CBD or intrahepatic stones underwent endoscopic and/or percutaneous treatment followed by extracorporeal shock wave lithotripsy. Percutaneous access to the biliary tract was chosen when an endoscopic approach was not possible (hepaticojejunostomy in 5 patients, 1 juxtapapillary diverticulum and I inflammatory bile duct stricture). Visualization of stones was achieved radiologically in 32 patients and by ultrasound in 24. The procedure was successful in 47 of 56 treated patients (83.9%). Clearance of the biliary tract was obtained in 25 cases (53%), whereas in 22 cases (47%) complete clearing of biliary tract was obtained only after endoscopic extraction of fragments (17 cases) or percutaneous (5 cases). The median number of shock waves in each session was 1725 (range , which were applied during one (n=30), two (n=22) or three sessions (n=4). The only complications were 1 case of symptomatic hyperamylasemia and 3 cases of macrohematuria. In conclusion, extracorporeal lithotripsy combined with endoscopic and/or percutaneous treatment is a real alternative to surgery for difficult stones.Keywords" Bile duct stones, endoscopic papillosphincterotomy, extracorporeal shock-wave lithotripsy, percutaneous transhepatic cholangiography
INTRODUCTIONCurrently, the treatment of common bile duct (CBD) stones as well as both multiple and complex intrahepatic lithiasis, is no longer exclusively surgical. Both endoscopic and transhepatic percutaneous approaches, sometimes combined, may offer successful treatment for most cases [1][2][3]. However, when very large stones have to be managed or anatomic conditions interfere with their removal, the success rates of nonsurgical methods are much lower [4]. On the other hand, in the elderly and in cases with complicated stones, surgery is marked by higher rates of morbidity and mortality, even though the figure has dramatically dropped in recent years [5][6][7]. Extracorporal lithotripsy has been demonstrated to be useful for treatment of large stones in the CBD and biliary intrahepatic ducts. Several studies confirming its effectiveness have been published [8][9][10][11]. We report here In our series, overall complications, spontaneously resolved in all cases, were 7.1%. There was no case of cholangitis, particularly dangerous in this kind of pathology, probably thanks to the drainage placed in the biliary tract in almost all cases and to antibiotic treatment during the process of clearing. In our series, there was no evidence of major complications, as has, instead, been described by some other groups [20][21][22] In conclusion, the choice between surgical and non-invasive removal of stones should in our point of view be made individually for each patient, taking into consideration the risk for surgery for that patient but also, in patients without surgical risk, the fact that fortheirbiliary patology they had already been submitted to previous multiple surgical interventions. The presence of very large stones (>35 mm), the only ones not cleared in our experien...