Electromechanical Effects of 1,25‐Dihydroxyvitamin D with Antiatrial Fibrillation Activities

Abstract

1,25[OH]2 D has direct electromechanical effects on the LA and can prevent or terminate AF.

Low-Level Vitamin D Is Associated with Atrial Fibrillation in Patients with Chronic Heart Failure

“…The present study found a relationship between the vitamin D level and AF in patients with HF is independent of BMI and HF stage, which indicates that vitamin D might have a direct effect on cardiomyocytes. These findings are similar to those of Hanafy et al, who reported that vitamin D protects against AF or helps reverse AF via a direct effect on atrial myocardium [19]. The relationship between the vitamin D level and hypertension is well known; however, there wasn't a difference in the levels of vitamin D among the causes of HF (CAD or HT).…”

Meta‐analysis of Vitamin D Deficiency and Risk of Atrial Fibrillation

“…By modulating the immune response, and thus, inflammatory pathways, vitamin D may exert additional effects on AF pathogenesis. Finally, Hanafy et al 36 found that 1,25[OH]2D increased the action potential duration and contractility in the left atrium of heart failure rabbits, suggested the direct electromechanical effects of vitamin D for enabling prevention or termination of AF.…”

Vitamin D deficiency and atrial fibrillation

“…Only articles that studied the relationship between vitamin D and AF were included in our review. Our search of the literature identified one experimental study [16] and five observational studies [17][18][19][20][21] that specifically investigated the relationship between vitamin D and AF (Table 1). …”

“…The electromechanical effects of the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25[OH] 2 D) on isolated rabbit left atria, and in heart failure (HF) rabbits that had undergone left coronary artery ligation, were examined by Hanafy et al [16]. An electrical stimulus was used to trigger action potentials (APs) in isolated left atria, with control specimens pre-treated with 0.1 μM ryanodine, an antagonist of the ryanodine receptor responsible for calcium induced calcium release and subsequent contraction of the myocardium.…”