Electromembrane extraction using deep eutectic solvents as the liquid membrane

Hansen, Frederik André; Santigosa‐Murillo, Elia; Ramos‐Payán, María; Muñoz, Marı́a; Øiestad, Elisabeth Leere; Pedersen‐Bjergaard, Stig

doi:10.1016/j.aca.2020.11.044

Cited by 75 publications

(25 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SLMs are summarized in Table 3, with assignment of potential analyte‐SLM interactions including ionic bonding, hydrogen bonding, cation‐π bonding, and π‐π stacking. The SLMs included traditional solvents used for EME as well as DESs, the latter have been very recently described with EME [22]. Ionic interactions were incorporated by addition of the ionic carrier DEHP.…”

Section: Resultsmentioning

confidence: 99%

“…Recently, EME was conducted with DESs based on mixtures of coumarin and thymol as SLM [22]. In said initial work, only a handful of polar basic model substances were studied.…”

Section: Resultsmentioning

confidence: 99%

“…Examples of other solvents for extraction of polar substances are 1‐ethyl‐2‐nitrobenzene [18, 19] and 1‐octanol [20, 21]. Very recently, we also demonstrated the application of deep eutectic solvents (DESs) based on coumarin and thymol as SLMs [22]. These solvents were efficient and provided exhaustive extractions for bases with log P −0.4 to +5.0.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Selectivity and efficiency of electromembrane extraction of polar bases with different liquid membranes—Link to analyte properties

Hansen

Tirandaz

Pedersen‐Bjergaard

2021

J of Separation Science

Self Cite

View full text Add to dashboard Cite

In the present fundamental study, selectivity and efficiency of electromembrane extraction of 50 polar basic substances (−6.7 < log P < +1.0) was systematically studied for ten different supported liquid membranes. For each model substance, 23 molecular descriptors were collected and these were investigated as potential parameters for understanding of extraction efficiency and selectivity by means of partial least squares regression. Overall, a highly aromatic deep eutectic solvent composed of coumarin and thymol with addition of 2% ionic carrier (di(2‐ethylhexyl) phosphate) provided the highest extraction efficiency with an average extraction yield of 69% from pure water samples, 55% from plasma, and 62% from urine. With this solvent system, ionic, cation‐π, and π‐π interactions between the supported liquid membrane and analytes were dominant. Supported liquid membranes without aromaticity, however, operated primarily based on hydrogen‐bonding interactions. This is the first time the relationship between analyte properties, solvent composition, and extraction yield has systematically been studied for polar bases in electromembrane extraction. This new knowledge represents a first step toward enabling future development and optimization of electromembrane extraction systems for polar bases based on rational design, rather than trial‐and‐error approaches.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Recently, EME was conducted with DESs based on mixtures of coumarin and thymol as SLM [22]. In said initial work, only a handful of polar basic model substances were studied.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Selectivity and efficiency of electromembrane extraction of polar bases with different liquid membranes—Link to analyte properties

Hansen

Tirandaz

Pedersen‐Bjergaard

2021

J of Separation Science

Self Cite

View full text Add to dashboard Cite

show abstract

“…Rajabi et al first adopted a completely eco-friendly and high solubility HDES (ChCl/1-phenylethanol) for HF-LPME in biological and environmental samples [62]. In 2021, Pedersen-Bjergaard et al first reported that a hydrophobic NADES (coumarin/thymol) was used as SLM for electromembrane extraction in a biological fluid sample and almost completely extracted different polar compounds [75]. This paper proved that DESs are very suitable for extraction in the form of SLM.…”

Section: Hf-lpmementioning

confidence: 94%

Application of Extraction and Determination Based on Deep Eutectic Solvents in Different Types of Environmental Samples

Wang

Jiang

et al. 2021

Water

View full text Add to dashboard Cite

Water sources are an indispensable resource for human survival. Monitoring the pollution status of the surrounding environment is necessary to protect water sources. Research on the environmental matrix of deep eutectic solvents (DESs) has expanded rapidly because of their high extraction efficiency for various target analytes, controllable synthesis, and versatile structure. Following the synthesis of hydrophobic deep eutectic solvents (HDESs), their application in aqueous matrices broadened greatly. The present review conducted a survey on the pollutant extraction methods based DESs in environmental matrices from two aspects, application methods and matrix types; discussed the potential risk of DESs to the environment and future development trends; and provided some references for researchers to choose DES-based extraction methods for environmental research.

show abstract

“…Hydrophobic DESs have been introduced more recently [9,10]. Thus, mixtures of coumarin and thymol have demonstrated much potential for extraction of ionizable compounds with a wide polarity window [11]. Besides, DESs decomposition has been exploited for extraction of hydrophobic compounds [12].…”

Section: Implementation Of Novel Materials In Sample Preparationmentioning

confidence: 99%