Electron arc therapy treatment planning verification with alanine/EPR dosimetry

Angelis, C. De; Mattacchioni, A; Onori, S.; Aragno, D.; Paula, Ugo De; Panichelli, V.

doi:10.1016/s0969-8043(00)00072-5

Cited by 13 publications

(6 citation statements)

References 6 publications

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“…No significant variation in the ratios was found at an uncertainty level of 0.6%, indicating that the alanine/EPR response per unit absorbed dose-to-water does not depend on the energy of the electron beam. The lack of energy dependence for electron beams found in this study is consistent with the previous studies of De Angelis et al (2000), Olsen et al (1990), Onori et al (1990) and Sharpe and Burns (1995), although the dosimeter compositions used in those studies are different.…”

Section: Energy Dependence Of Alanine Response For Electronssupporting

confidence: 92%

“…There are a few published studies focusing on the use of alanine in radiation therapy with electron beams. In De Angelis et al's (2000) work, alanine was applied in electron arc therapy for treatment planning verification and the alanine-determined doses were in very good agreement with the ion-chamber-determined doses. Their investigation also shows no change in the response per unit absorbed dose-to-water of alanine pellets (alanine/polyethylene) in the energy range 4-16 MeV.…”

Section: Introductionmentioning

confidence: 81%

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An experimental and Monte Carlo investigation of the energy dependence of alanine/EPR dosimetry: II. Clinical electron beams

Zeng

McEwen²,

Rogers

et al. 2005

Phys. Med. Biol.

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The energy dependence of alanine/EPR dosimetry for 8, 12, 18 and 22 MeV clinical electron beams was investigated by experiment and by Monte Carlo simulations. Alanine pellets in a waterproof holder were irradiated in a water phantom using an Elekta Precise linear accelerator. The dose rates at the reference point were determined following the TG-51 protocol using an NACP-02 parallel-plate chamber calibrated in a (60)Co beam. The EPR spectra of irradiated pellets were measured using a Bruker EMX 081 EPR spectrometer. Experimentally, we found no significant change in alanine/EPR response to absorbed dose-to-water over the energy range 8-22 MeV at an uncertainty level of 0.6%. However, the response for high-energy electrons is about 1.3 (+/-1.1)% lower than for (60)Co. The EGSnrc Monte Carlo system was used to calculate the ratio of absorbed dose-to-alanine to absorbed dose-to-water and it was shown that there is 1.3 (+/-0.2)% reduction in this ratio from the (60)Co beam to the electron beams, which confirms the experimental results. Alanine/EPR response per unit absorbed dose-to-alanine was also investigated and it is the same for high-energy electrons and (60)Co gamma-rays.

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Section: Energy Dependence Of Alanine Response For Electronssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 81%

An experimental and Monte Carlo investigation of the energy dependence of alanine/EPR dosimetry: II. Clinical electron beams

Zeng

McEwen²,

Rogers

et al. 2005

Phys. Med. Biol.

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“…Other clinical applications of EPR spectrometry of alanine include brachytherapy (De Angelis et al, 1999), proton therapy (Nichiporov et al, 1995;Onori et al, 1997), electron arc therapy treatment planning verification (De Angelis et al, 2000) and total body irradiation (Indovina et al, 1989). Desrosiers et al (1993) reported on the results of measurements of radiopharmaceutical absorbed doses.…”

Section: Quality Control For Therapeutic Radiation Facilities Using Ementioning

confidence: 99%

Electron paramagnetic resonance (EPR) in medical dosimetry

Schauer

Iwasaki

Romanyukha

et al. 2006

Radiation Measurements

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This paper describes the fundamentals of electron paramagnetic resonance (EPR) and its application to retrospective measurements of clinically significant doses of ionizing radiation. X-band is the most widely used in EPR dosimetry because it represents a good compromise between sensitivity, sample size and water content in the sample. Higher frequency bands (e.g., W and Q) provide higher sensitivity, but they are also greatly influenced by water content. L and S bands can be used for EPR measurements in samples with high water content but they are less sensitive than X-band. Quality control for therapeutic radiation facilities using X-band EPR spectrometry of alanine is also presented.

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“…However, studies have been conducted to test the precision of EPR/alanine dosimetry for use in the therapeutic dose ranges [3]. The advanced radiotherapy beam modalities and applications that have been verified using alanine dosimetry include intensity modulated radiotherapy (IMRT); electron, proton, carbon ion, and neutron beams radiotherapy; tomotherapy [4]; gamma knife [5]; cyberknife [6]; brachytherapy [7]; small field dosimetry [8]; in vivo dosimetry [9]; electron arc therapy treatment planning verification [10]; total body irradiation [11]; and blood irradiation [12]. In addition, the EPR/alanine dosimetry was used in national audits of radiotherapy centers in other countries, such as the UK [13] and Italy [14].…”

Section: Introductionmentioning

confidence: 99%

Verification of the pure alanine in PMMA tube dosimeter applicability for dosimetry of radiotherapy photon beams: a feasibility study

Al-Karmi

Ayaz

Al-Enezi

et al. 2015

Australas Phys Eng Sci Med

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Alanine dosimeters in the form of pure alanine powder in PMMA plastic tubes were investigated for dosimetry in a clinical application. Electron paramagnetic resonance (EPR) spectroscopy was used to measure absorbed radiation doses by detection of signals from radicals generated in irradiated alanine. The measurements were performed for low-dose ranges typical for single-fraction doses often used in external photon beam radiotherapy. First, the dosimeters were irradiated in a solid water phantom to establish calibration curves in the dose range from 0.3 to 3 Gy for 6 and 18 MV X-ray beams from a clinical linear accelerator. Next, the dosimeters were placed at various locations in an anthropomorphic pelvic phantom to measure the dose delivery of a conventional four-field box technique treatment plan to the pelvis. Finally, the doses measured with alanine dosimeters were compared against the doses calculated with a commercial treatment planning system (TPS). The results showed that the alanine dosimeters have a highly sensitive dose response with good linearity and no energy dependence in the dose range and photon beams used in this work. Also, a fairly good agreement was found between the in-phantom dose measurements with alanine dosimeters and the TPS dose calculations. The mean value of the ratios of measured to calculated dose values was found to be near unity. The measured points in the in-field region passed dose-difference acceptance criterion of 3% and those in the penumbral region passed distance-to-agreement acceptance criterion of 3 mm. These findings suggest that the pure alanine powder in PMMA tube dosimeter is a suitable option for dosimetry of radiotherapy photon beams.

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Electron arc therapy treatment planning verification with alanine/EPR dosimetry

Cited by 13 publications

References 6 publications

An experimental and Monte Carlo investigation of the energy dependence of alanine/EPR dosimetry: II. Clinical electron beams

An experimental and Monte Carlo investigation of the energy dependence of alanine/EPR dosimetry: II. Clinical electron beams

Electron paramagnetic resonance (EPR) in medical dosimetry

Verification of the pure alanine in PMMA tube dosimeter applicability for dosimetry of radiotherapy photon beams: a feasibility study

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