Electron impact mass spectrometry of some potential neuroleptic trans‐(2‐Amino Methyl)‐Cycloalkyl Aryl Ketones

Electron impact mass spectrometry of some neuroleptic amino alkyl thieno[β]cycloalkanones

“…2 Analogously to the derivatives of the benzene series, most of the thiophene containing compounds have shown a remarkable antipsychotic activity, in both in vitro and in vivo assays. 3 Mass spectrometry has already been shown to be a valuable analytical tool for the characterization of butyrophenones 4 and, in the present paper, we report on the mass spectrometric behaviour of a series of these compounds, namely: 1-[(4-oxo-4,5,6,7-tetrahydrobenzo[b]thiophen-6-yl)methyl]-4-(2'-pyridyl)piperazine (1) 2-Aminoethyl-4-oxo-4,5,6,7-tetrahydrobenzo[b]thiophenes were prepared via DCC (dicyclohexylcarbodiimide) mediated coupling of the corresponding amines and ketoacids followed by amide reduction, while 3-aminomethyl-4oxo-4,5,6,7-tetrahydrobenzo[b]thiophenes were synthesized by acid mediated ring closure of the corresponding acyclic amine derivatives. The study was carried out in electron ionization conditions and with the aid of metastable ion 5 studies, low energy collision experiment 6 and accurate mass measurements.…”