Electron microscopic observations on structures resembling myxovirus in human sarcomas

Györkey, Ferenc; Sinkovics, Joseph G.; Györkey, Phyllis

doi:10.1002/1097-0142(197106)27:6<1449::aid-cncr2820270627>3.0.co;2-3

Cited by 66 publications

(18 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may, therefore, provide an explanation for clinical observations in the higher grades/ stages of prostate carcinomas, which correlate with lower levels of cellular PAcP expression (3,(47)(48)(49)(50). These high grade tumors will eventually escape from anti-androgen or androgen deprivation therapy, despite unaltered expression of functional AR in these carcinomas (12,13,46).…”

Section: Fig 3 Expression Of Psa and Pacp In Different Lncap Cellsmentioning

confidence: 99%

“…Our preliminary results indicate that pp185 co-migrates with ErbB-2/neu protein in SDS gels. 3 Interestingly, in several independent systems, an induction of cellular differentiation by various differentiation agents is associated with a decreased cell growth and an increased expression of cellular PTPase activity (53)(54)(55)(56)(57). Thus, the study of PAcP, a differentiationassociated PTPase, for its possible functional role in growth regulation of prostate epithelium may provide us with useful information in understanding the putative role of other differentiation-associated PTPases in their respective cell growth regulation.…”

Section: Fig 3 Expression Of Psa and Pacp In Different Lncap Cellsmentioning

confidence: 99%

“…Development and maintenance of differentiated function of the normal prostate gland require androgen (2). Androgen has also been implicated in the carcinogenesis of prostate epithelium (3,4). This is evidenced by observations that, at least in the early phase of prostate carcinogenesis, the growth of carcinoma cells can be stimulated by androgen and arrested by androgen withdrawal (5).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Expression of Human Prostatic Acid Phosphatase Correlates with Androgen-stimulated Cell Proliferation in Prostate Cancer Cell Lines

Lin¹,

Meng²,

Rao³

et al. 1998

Journal of Biological Chemistry

124

164

View full text Add to dashboard Cite

Androgen plays a critical role in regulating the growth and differentiation of normal prostate epithelia, as well as the initial growth of prostate cancer cells. Nevertheless, prostate carcinomas eventually become androgen-unresponsive, and the cancer is refractory to hormonal therapy. To gain insight into the mechanism involved in this hormone-refractory phenomenon, we have examined the potential role of the androgen receptor (AR) in that process. We have investigated the expression of AR and two prostate-specific androgen-responsive antigens, prostatic acid phosphatase (

show abstract

Section: Fig 3 Expression Of Psa and Pacp In Different Lncap Cellsmentioning

confidence: 99%

Section: Fig 3 Expression Of Psa and Pacp In Different Lncap Cellsmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Expression of Human Prostatic Acid Phosphatase Correlates with Androgen-stimulated Cell Proliferation in Prostate Cancer Cell Lines

Lin¹,

Meng²,

Rao³

et al. 1998

Journal of Biological Chemistry

124

164

View full text Add to dashboard Cite

show abstract

“…Despite a superficial resemblance to the nucleoprotein cores of myxoviruses (1,2,8,22), the tubules observed in endothelial cells and lymphocytes of patients with SLE appear to lack the helical periodicity of myxovirus cores (25,28,30). In this respect, the tubules also differ from the intranuclear filaments described in chronic polymyositis or subacute sclerosing panencephalitis (31,32).…”

Section: Nature and Pathogenesis Of Trsmentioning

confidence: 99%

Abnormal Structures in Circulating Lymphocytes from Patients with Systemic Lupus Erythematosus and Related Diseases

Grimley

Decker

Michelitch

et al. 1973

Arthritis & Rheumatism

View full text Add to dashboard Cite

A prospective electron microscopic study, incorporating blind controls, demonstrated tubuloreticular structures (TRS) in the buffy coat lymphocytes of 32 patients with connective tissue disease. From 1 to 8% of the lymphocyte sections were involved. The abnormal structures consisted of interwoven, electron-dense tubules (220 to 280 A diameter) which were located within the endoplasmic reticulum. Tubuloreticular structures were found in lymphocytes from 20 of 30 patients with systemic lupus erythematosus (SLE), 2 of 4 with discoid lupus erythematosus, 8 of 20 with other connective tissue disease and none of 22 control cases. Clinical evaluation of the patients with SLE disclosed no specific differences between those with TRS-positive or TRS-negative lymphocytes; there were some indications of greater disease activity in the TRS-positive group. The biologic nature of TRS is unknown, but they have been linked to virus infection under both clinical and experimental conditions. systemic lupus erythematosus (SLE) (3-6) and many patients with related diseases of connective tissues (7-9). We now report a significant frequency of morphologically identical structures in the circulating lymphocytes of such patients.T h e tubules in question have been distinguished by their ultrastructural appearance. They are relatively electron-dense and measure in the range of 220 to 280 A in diameter. They are interwoven within membrane-limited compartments which can often be identified as dilatations of the endoplasmic reticulum or perinuclear space. T h e biologic nature of these structures is still unknown, and we have adopted the description tu buloreticular struclures (TRS) also proposed by Dalton (1 0).T h e possibility of finding T R S in circulating cells was suggested by electron microscopic examination of a skin biopsy from a 24-year-old man with SLE with subcutaneous nodules and histologic evidence of chronic vasculitis. Thin

show abstract

“…The roll of zinc and its possible causal effects in prostate cancer has attracted attention in recent years. A human prostate gland has a unique feature to possess highlevel accumulation of zinc compared to other organs [1]. In prostate cancer tissue the unique zinc metabolism is altered, resulting in the decrease of zinc level in the epithelial cells [1,2].…”

Section: Introductionmentioning

confidence: 99%

Investigations on Distribution and Quantity of Zinc in Prostate Cancer Using Synchrotron Radiation Microbeams

Kawakami¹,

Ide‐Ektessabi²,

Sugimura³

et al. 2003

AIP Conference Proceedings

View full text Add to dashboard Cite

Synchrotron radiation (SR) micro beams were used to investigate ultra-trace elements in a single cell. X-ray fluorescence (XRF) spectroscopy using SR was applied to determine the distribution and density of the ultra-trace elements in incubated prostate cancer cells. Metallic elements such as zinc, iron and copper play an important role in the metabolism and regulatory dynamics of cells. In this study, we focused on zinc because the prostate tissues contain the highest levels of zinc compared to any other tissues in the body and the level of zinc is a factor that influences the progress of malignancy. We measured two types of cells (LNCaP and C4-2) that were incubated in the normal culture medium, zinc-contained one or testosterone-contained one. The distribution and density of zinc, calcium, copper and iron have close relations to the existence of zinc and androgen in the culture medium. † Corresponding author: Ari Ide-Ektessabi.

show abstract

Electron microscopic observations on structures resembling myxovirus in human sarcomas

Abstract: Human tumors of mesenchymal origin contain cytoplasmic structures resembling ribonucleoprotein strands of paramyxoviruses. Similar structures have previously been reported in collagen diseases. The nature and function of these structures remain unresolved.

Cited by 66 publications

References 21 publications

Expression of Human Prostatic Acid Phosphatase Correlates with Androgen-stimulated Cell Proliferation in Prostate Cancer Cell Lines

Expression of Human Prostatic Acid Phosphatase Correlates with Androgen-stimulated Cell Proliferation in Prostate Cancer Cell Lines

Abnormal Structures in Circulating Lymphocytes from Patients with Systemic Lupus Erythematosus and Related Diseases

Investigations on Distribution and Quantity of Zinc in Prostate Cancer Using Synchrotron Radiation Microbeams

Contact Info

Product

Resources

About