Electron Microscopic Studies of Capillary Permeability in Normal and Ames Waltzer Deaf Mice

Osako, Shigeto; Hilding, David A.

doi:10.3109/00016487109125376

Cited by 57 publications

(10 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are many reports about mutant strains exhibiting behavioral abnormalities due to inner ear defects (Deol, 1954;Deol and Green, 1966;Osato and Hilding, 1971;Steel et al, 1983;Kitamura et al, 1992;Sjostrom and Anniko, 1992). We previously reported that BUS mutant is deaf in total life and could be classified in this 'circling' mutants group .…”

Section: A Hanai Et A1mentioning

confidence: 99%

BUS/ldr, a Mutant Mouse Strain Exhibiting Abnormal Behaviors: Behavioral Similarities of BUS Mice and Chemically Labyrinthectomized Mice

Hanai

Tsuji

Otani

et al. 1995

Congenital Anomalies

View full text Add to dashboard Cite

The behavioral abnormalities of homozygotes (bus/bus) of mutant bustling mice, BUS/ldr, were characterized in comparison with those of heterozygotes (+/bus) and of chemically labyrinthectomized mice. Homozygotes were 4‐fold more active than heterozygotes, as evaluated in an open field (11 × 17 cm) for 24 hr by means of Animex. Homozygotes revealed the lack of righting reflex and of head nystagmus on a rotating board, the frequent backward‐moving and the inability to swim, in addition to characteristic behaviors such as circling, head bobbing and head tossing. Bilaterally labyrinthectomized mice behaviorally mimicked BUS homozygotes: The behavioral patterns of operated animals were essentially the same as those of BUS homozygotes with respect to all reflex and locomotor indices employed, suggesting that some peripheral vestibular dysfunction, though unidentified yet, is attributed to abnormal behaviors of BUS mice. Unilaterally labyrinthectomized mice were not hyperactive, nor exhibited circling behavior.

show abstract

Section: A Hanai Et A1mentioning

confidence: 99%

BUS/ldr, a Mutant Mouse Strain Exhibiting Abnormal Behaviors: Behavioral Similarities of BUS Mice and Chemically Labyrinthectomized Mice

Hanai

Tsuji

Otani

et al. 1995

Congenital Anomalies

View full text Add to dashboard Cite

show abstract

“…The av mouse mutation was first reported in 1961 (Schaible 1961), and, since then, there have been several reports of inner ear pathology in av mutants, although most reports have focused on cochlear abnormalities (Osako and Hilding 1971;Alagramam et al 1999Alagramam et al , 2000Raphael et al 2001). Osako and Hilding studied the physiology of av mice (presumed to be the original allele of av) and found no evidence of auditory function at any time during postnatal development or in the adult.…”

Section: Introductionmentioning

confidence: 99%

“…Although the av mice displayed circling behavior, Osako and Hilding found no anatomical defects in the vestibular apparatus. Transmission electron microscopic study of the saccular neuroepithelium in Badult^(age not specified) av mice failed to reveal any ultrastructural abnormalities in the sensory cells, supporting cells, or neural elements (Osako and Hilding 1971). Therefore the structural basis for the early-onset circling behavior in av mice is not clear.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Vestibular Dysfunction in the Mouse Model for Usher Syndrome 1F

Alagramam

Stahl

Jones

et al. 2005

JARO

View full text Add to dashboard Cite

The deaf-circling Ames waltzer (av) mouse harbors a mutation in the protocadherin 15 (Pcdh15) gene and is a model for inner ear defects associated with Usher syndrome type 1F. Earlier studies showed altered cochlear hair cell morphology in young av mice. In contrast, no structural abnormality consistent with significant vestibular dysfunction in young av mice was observed. Light and scanning electron microscopic studies showed that vestibular hair cells from presumptive null alleles Pcdh15 av-Tg and Pcdh15 av-3J are morphologically similar to vestibular sensory cells from control littermates, suggesting that the observed phenotype in these alleles might be a result of a central, rather than peripheral, defect. In the present study, a combination of physiologic and anatomic methods was used to more thoroughly investigate the source of vestibular dysfunction in Ames waltzer mice. Analysis of vestibular evoked potentials and angular vestibulo-ocular reflexes revealed a lack of physiologic response to linear and angular acceleratory stimuli in Pcdh15 mutant mice. Optokinetic reflex function was diminished but still present in the mutant animals, suggesting that the defect is primarily peripheral in nature. These findings indicate that the mutation in Pcdh15 results in either a functional abnormality in the vestibular receptor organs or that the defects are limited to the vestibular nerve. AM1-43 dye uptake has been shown to correlate with normal transduction function in hair cells. Dye uptake was found to be dramatically reduced in Pcdh15 mutants compared to control littermates, suggesting that the mutation affects hair cell function, although structural abnormalities consistent with significant vestibular dysfunction are not apparent by light and scanning electron microscopy in the vestibular neuroepithelia of young animals.

show abstract

“…22 Subsequently, three other spontaneously occurring allelic mutations were identified: Pcdh15 avJ , Pcdh15 av-2J , and Pcdh15 av-3J . 23 Affected mice exhibit circling behavior and hearing loss associated with a severe degeneration of cochlear and saccular sensory structures that is evident in adult animals.…”

mentioning

confidence: 99%

“…23 Affected mice exhibit circling behavior and hearing loss associated with a severe degeneration of cochlear and saccular sensory structures that is evident in adult animals. 22 Herein, we report the retinal phenotype of the Ames waltzer mouse, a potential model for Usher syndrome type 1F (USH1F). The publication costs of this article were defrayed in part by page charge payment.…”

mentioning

confidence: 99%

Assessment of Retinal Structure and Function in Ames Waltzer Mice

Ball

Bardenstein

Alagramam

2003

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

Electron Microscopic Studies of Capillary Permeability in Normal and Ames Waltzer Deaf Mice

Cited by 57 publications

References 11 publications

BUS/ldr, a Mutant Mouse Strain Exhibiting Abnormal Behaviors: Behavioral Similarities of BUS Mice and Chemically Labyrinthectomized Mice

BUS/ldr, a Mutant Mouse Strain Exhibiting Abnormal Behaviors: Behavioral Similarities of BUS Mice and Chemically Labyrinthectomized Mice

Characterization of Vestibular Dysfunction in the Mouse Model for Usher Syndrome 1F

Assessment of Retinal Structure and Function in Ames Waltzer Mice

Contact Info

Product

Resources

About