Electron Microscopy and the Functional Significance of a New Cellular Structure in Plasmocytes: A Review

Studies of the Primary and the Secondary Immune Responses of Lymph Nodes Draining Homografts of Fresh Cancellous Bone (With Particular Reference to Mechanisms of Lymph Node Reactivity)

“…The pyroninophilic lymphoid cells found in lymph nodes draining homografts of skin and iliac bone which have dense particles freely dispersed throughout their cytoplasm and a nucleus which is sometimes indented, are similar in ultrastructural appearance to the cells described by other workers as primitive cells or large lymphocytes (Sorenson, 1960), lymphoblasts (Granboulan, 1960;Bernhard and Granboulan, 1960), lymphogonia (Amano, 1958), and precursors of plasmocytes (Braunsteiner and Pakesch, 1955). Cells of this type are generally believed to belong to the lymphocytic series and, after mitotic division, produce small lymphocytes.…”

“…The second ultrastructural type of large and medium lymphoid cells in which the dense particles are not freely dispersed but are attached to an elaborate system of cytoplasmic membranes is less commonly seen in the activated lymphoid tissue than the former type of cell. It is, however, similar in ultrastructural appearance to those cells that are generally considered to be the main producers of serum antibodies, namely, the plasma cell series (Braunsteiner et al, 1953;Braunsteiner and Pakesch, 1955;Amano, 1958;ThiCry, 1960;Bernhard and Granboulan, 1960;Bessis, 1961). In the present state of semantics in this field such large and medium lymphoid dells should be included in the plasma cell series; it seems likely that they produce serum antibodies.…”

The Form Birefringence of Lamellar Systems Containing Three or More Components

“…these equations are of interest: 1. If all but two of the d's become zero or if all but two of the K's become equal to one another, both equations(5) and(6) reduce to the form in which the Wiener equation for plates is usually quoted1:…”

Plasma Cell Neoplasia in a Single Host: A Mosaic of Different Protein-Producing Cell Types

“…It is known that most of the cytoplasm of the neoplastic plasma cells consists of a system of membranes, sacs, and ribosomes (free and attached); i.e., an ergastoplasm. This complex structure is associated with protein synthesis in normal plasma cells (13,14) and other active, protein-forming (15) cell types. One of the important questions regarding protein formation in neoplastic plasma cells, is what role the nucleus (DNA) plays.…”