Electron Microscopy in Determining Origin of Metastatic Adenocarcinomas

Ga, Herrera; Be, Reimann

doi:10.1097/00007611-198412000-00020

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1985

2010

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Cited by 13 publications

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“…4,5,11 Findings are not pathognomonic. Nevertheless, the following examples from this series illustrate that some ultrastructural features taken in the proper 460…”

Section: Discussionmentioning

confidence: 99%

Transmission Electron Microscopy of Fine Needle Aspiration Biopsies of Metastases

Facundo¹,

Quinonez²,

Ravinsky³

2003

Acta Cytologica

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“…4,5,11 Findings are not pathognomonic. Nevertheless, the following examples from this series illustrate that some ultrastructural features taken in the proper 460…”

Section: Discussionmentioning

confidence: 99%

Transmission Electron Microscopy of Fine Needle Aspiration Biopsies of Metastases

Facundo¹,

Quinonez²,

Ravinsky³

2003

Acta Cytologica

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“…Some of the criteria enumerated above, used to suggest a primary site for malignant cells in effusions, have been found reliable for determining primary sites for metastatic adenocarcinomas of unknown origin in solid tissues. 14…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural studies of malignant cells in fluids

Herrera

Wilkerson

1985

Diagnostic Cytopathology

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An ultrastructural study was performed on 104 sequential fluids in which more than eight malignant cells per ten high-power fields were found by routine light microscopy. The study included fluids associated with mesotheliomas, melanomas, lymphomas, squamous-cell carcinomas, small-cell anaplastic (oat-cell) carcinomas, and adenocarcinomas. Electron microscopic examination reliably separated lymphoid from epithelial malignancies and benign from reactive and malignant mesothelial cell proliferations. It also suggested or identified a primary site for the adenocarcinomas. Ultrastructural examination of fluids can be a valuable adjunct to routine light microscopy of cytology specimens. No false-positive diagnoses were encountered. Sampling was the most significant limitation for this technique.

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