Electron microscopy of lipofuscin pigment stained by the schm�rl and fontana techniques

Hendy, R.

doi:10.1007/bf00277378

Cited by 5 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, glycogens were mainly localized in GLAST+ astrocytes and their progenitor cells ( S3A Fig ), while they were much less localized in the PDGFRα+ OPCs or excluded from Iba1+ microglia ( S3B–S3D Fig ). Microglia somas were identified using established criteria, including lysosomes, lipofuscin, and a long ER ( Fig 1D ) [ 19 , 30 , 31 ]. Fig 1 also shows a unique cell that contains relatively sparse cytoplasmic organelles and few or no glycogen granules, but no intermediate filaments (cell C in Fig 1 , S1 and S2 Figs).…”

Section: Resultsmentioning

confidence: 99%

Ultrastructural characteristics of oligodendrocyte precursor cells in the early postnatal mouse optic nerve observed by serial block-face scanning electron microscopy

et al. 2022

View full text Add to dashboard Cite

Oligodendrocyte precursor cells (OPC) arise from restricted regions of the central nervous system (CNS) and differentiate into myelin-forming cells after migration, but their ultrastructural characteristics have not been fully elucidated. This study examined the three-dimensional ultrastructure of OPCs in comparison with other glial cells in the early postnatal optic nerve by serial block-face scanning electron microscopy. We examined 70 putative OPCs (pOPC) that were distinct from other glial cells according to established morphological criteria. The pOPCs were unipolar in shape with relatively few processes, and their Golgi apparatus were localized in the perinuclear region with a single cisterna. Astrocytes abundant in the optic nerve were distinct from pOPCs and had a greater number of processes and more complicated Golgi apparatus morphology. All pOPCs and astrocytes contained a pair of centrioles (basal bodies). Among them, 45% of pOPCs extended a short cilium, and 20% of pOPCs had centrioles accompanied by vesicles, whereas all astrocytes with basal bodies had cilia with invaginated ciliary pockets. These results suggest that the fine structures of pOPCs during the developing and immature stages may account for their distinct behavior. Additionally, the vesicular transport of the centrioles, along with a short cilium length, suggests active ciliogenesis in pOPCs.

show abstract

Section: Resultsmentioning

confidence: 99%

Ultrastructural characteristics of oligodendrocyte precursor cells in the early postnatal mouse optic nerve observed by serial block-face scanning electron microscopy

et al. 2022

View full text Add to dashboard Cite

show abstract

“…It is generally agreed that its formation involves oxidation of lipids, and that it develops in lesions where unsaturated fatty acids accumulate in abnormal torm and amoutit (Hartroft & Porta 1965). Seveial investigators have suggested that ceroid arises through the breakdown of damaged otganclles and membranes by lysosotnes which arc unable to digest the material completely (Hendy 1971). Hess (1955) proposed a tnitochondrial origin based on electron microscopic observations.…”

Section: Discussionmentioning

confidence: 99%

Pigmented cells in adenolymphoma (Warthin's tumor)

Buchner

David

1977

J Oral Pathology Medicine

View full text Add to dashboard Cite

A study of a series of adenolymphomas showed the presence of pigmented cells in the lymphoid stroma in 85 % of the cases. The pigmented cells contained light brown cytoplasmic pigment and manifested sudanophila, acid‐fastness, silver reduction capacity, PAS positivity and yellow autofluorescence in ultraviolet light. The morphology, histochemical reactions and autofluorescence suggest that the pigmented cells are macrophages containing ceroid derived from breakdown of damaged organelles of the epithelial tumor cells. It is possible that these cells play a role in the elimination of undigestable pigment material present in the cystic spaces of the tumor.

show abstract