Electron Microscopy of Mucosa of Small Intestine

Trier, Jerry S.; Phelps, Patricia C.; Rubin, Cyrus E.

doi:10.1001/jama.1963.63700090014014

Cited by 36 publications

(22 citation statements)

References 6 publications

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“…Among these, the mucosa plays essential roles in digestion and absorption, whereas the submucosa acts as the skeleton of the intestine to integrate the internal mucosa and the external muscle layers. A considerable number of studies have dealt with questions in intestinal morphology (for review; TRIER and RUBIN, 1965;KULENKAMPFF, 1975;YAMAMOTO, 1982;MADARA and TRIER, 1987). However, most of the previous efforts, have focused on the epithelial cells from rather limit-ed view points, and the overall structure of the intestinal mucosa has been far from fully understood.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional structure of the rat intestinal wall (Mucosa and submucosa).

Komuro

Hashimoto

1990

Archives of Histology and Cytology

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Section: Discussionmentioning

confidence: 99%

Three-dimensional structure of the rat intestinal wall (Mucosa and submucosa).

Komuro

Hashimoto

1990

Archives of Histology and Cytology

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“…The space system may possibly play a role in absorption or exchange of nutrients as intraepithelial compartments for the volume regulation of absorbed fluid or supplied plasma (TRIER and MADARA, 1981).…”

Section: Discussionmentioning

confidence: 99%

Intercellular spaces in the lymph nodule associated epithelium of the rabbit Peyer's patch and appendix.

Ogawa

Miyoshi

1985

Arch. Histol. Jap., Arch. Histol. Jpn

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Summary. Intercellular spaces in the epithelium of the rabbit Peyer's patch and appendix were examined by scanning and transmission electron microscopy to elucidate their threedimensional structure and their relationship to the reticular spaces in the underlying lymph nodule.Two types of intercellular spaces were distinguished: regularly arranged tubular channels and irregularly winding tunnels. The tubular channels were observed around normal enterocytes on the villi or internodular folds and apical portions of nodule domes. The channel spaces were lined with a successive arrangement of belt-like intercrestal surfaces of prismatic enterocytes and variously sized processes on the crests. The processes adjoining opposed crests formed a ladder-like structure or pectinate septa between neighboring channels.The irregularly winding tunnels were formed among processes of irregularly shaped cells corresponding to FAE cells (BOCKMAN and COOPER, 1973) or M cells (OWEN and JONES, 1974) in the nodule associated epithelium. In the appendix, the tunnels were frequently organized into two-storey spaces, the adlumenal and basal spaces, which were incompletely separated by cytoplasmic processes. These tunnels continued by pores in the basement membrane to the reticular spaces in the underlying lymph nodules. Furthermore, the tunnels and the basement membrane pores constantly contained single or grouped free cells or their processes.The findings in the present study suggest that the tubular channels are intraepithelial compartments for the absorption of nutrients and fluid, and the irregular tunnels are an intraepithelial network of spaces for the housing of lymphoid cells coming from the underlying lymph nodule. The Peyer's patch and appendix are important constituents of the gut associated lymphoid tissue. In both organs, the lumenal portions of the lymph nodules bulge into the intestinal lumen and closely associate with the overlying epithelium.The nodule or follicle associated epithelium (FAE) is thought to play a mediating role in conveying immunological information from the intestinal lumen to the underlying lymphatic tissue (BOCKMAN et al., 1983). For this mediation function, specialized cells have been proposed, which are morphologically distinguishable from common enterocytes.

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“…A similar sequence has been observed in goblet cells of the cat trachea (Tandler, B., unpublished observations). Trier and Rubin, (48) have also noted that merocrine secretion is the norm in intestinal goblet cells, but that apocrine secretion occurs after a potent secretory stimulus. We suggest that proteinases similarly may be potent stimuli for goblet cells in large airways.…”

Section: Discussionmentioning

confidence: 99%

Proteinases of Pseudomonas aeruginosa evoke mucin release by tracheal epithelium.

et al. 1984

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Abstract. We have determined the potential of exoproducts from pathogenic bacteria to stimulate the release of high molecular weight mucins from goblet cells of airway epithelium in a rabbit tracheal explant system. Culture supernatants from proteolytic strains of Pseudomonas aeruginosa and Serratia marcescens, but not supernatants from a number of non-proteolytic strains, released mucins from goblet cells. Highly purified elastase and alkaline proteinase from P. aeruginosa stimulated goblet cell mucin release in a dose-dependent fashion. Lipopolysaccharide, exotoxin A, and alginate of P. aeruginosa did not possess mucin release properties. Proteolytic activity was required for mucin release by P. aeruginosa elastase, but such release in goblet cells was not mediated by cyclic AMP. Morphologic studies suggested rapid release of mucins from goblet cells in response to elastase by a process resembling apocrine secretion. Several nonbacterial proteinases mimicked the effect of Pseudomonas proteases. These studies provide support for the hypothesis that bacterial and other proteinases play a role in the pathogenesis of mucus hypersecretion in acute and chronic lung infections.

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Electron Microscopy of Mucosa of Small Intestine

Cited by 36 publications

References 6 publications

Three-dimensional structure of the rat intestinal wall (Mucosa and submucosa).

Three-dimensional structure of the rat intestinal wall (Mucosa and submucosa).

Intercellular spaces in the lymph nodule associated epithelium of the rabbit Peyer's patch and appendix.

Proteinases of Pseudomonas aeruginosa evoke mucin release by tracheal epithelium.

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