Electron Microscopy of Skeletal Aging

Tonna, Edgar A.

doi:10.1007/978-1-4684-3929-8_7

Cited by 8 publications

(12 citation statements)

References 111 publications

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“…In young adult bone, an osomiphilic lamina is observed at the surface of the lacunae that increases in thickness and density with age [Tonna, 1981]. In young adult bone, an osomiphilic lamina is observed at the surface of the lacunae that increases in thickness and density with age [Tonna, 1981].…”

Section: Discussionmentioning

confidence: 99%

“…Osteocytes play an important role in calcium homeostasis [Jande, 1971;Tonna, 1981]. These cells are involved in the storage and release of needed calcium and phosphate mobilized from the perilacunar surfaces [Belanger, 1965;Baylink and Wegedal, 1971;Tonna, 1972Tonna, , 1973.…”

Section: Discussionmentioning

confidence: 99%

“…In his excellent review of skeletal aging, Tonna [1981] concluded "although electron microscopic studies of skeletal tissues are numerous, especially when the growing dental literature is added, in investigations of aging bone, cartilage, and associated soft connective tissue are appallingly exigious, and most of the information comes from several laboratories". In contrast, there were very few studies of the changes in bone in aged animals and man during this period.…”

mentioning

confidence: 99%

“…The aging osteocytes also showed degenerative changes with lipofuchsin granules followed by cell death and empty lacunae. Tonna [1965Tonna [ , 1981 and Jowsey [1960] have shown in aged bone that the aged process limits the capability of calcium homeostasis in old mice and man leading to physiologic atrophy in old age. Manson [1964] by the use of microradiographs reported that in aged man mandibles there is an increasing number of high density resting lines which he felt indicated not only interrupted deposition but an impairment in the diffusion of ions from high density tissue.…”

mentioning

confidence: 99%

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Changes in the Microvasculature and Interstitium of Aged Human Mandibles and Maxillae¹

1983

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The present study describes the age changes to the microvasculature and connective tissue interstitium of the osteons and periosteums of aged human mandibles and maxillae. The mandibles and maxillae obtained from 14 and 19 year old males, respectively, were also studied. In the nutrient canals of the aged osteons, the walls of the arterioles and venules stained intensely PAS positive, and alcian blue negative. The walls of the blood capillaries were thick and strongly PAS positive. There was a deposition of PAS positive material in the connective tissue stroma of the nutrient canals which progressed to the obliteration of the canal space. Many of the nutrient canals exhibited diffuse calcification within the connective tissue interstitium localized around the blood vessels. The lacunae and canaliculi of those osteons in which the nutrient canals were partially or completely obliterated were filled with PAS material. None of these histochemical changes were seen in the osteons of young individuals. The microvasculature of the aged periosteum showed similar changes. The periosteal tissue consisted of thick collagenous bundles and few osteogenic cells. There was a thin darkly stained amorphous calcified layer forming the bone surface.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Changes in the Microvasculature and Interstitium of Aged Human Mandibles and Maxillae¹

1983

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“…This tissue is divided into two layers, based on cellular and extracellular matrix components: a thick outer fibrous layer and an inner osteogenic layer (Simpson, 1985;Squier et al, 1990;Tonna, 1974). The osteogenic layer is known to play key roles in intramembranous ossification during the growth of long bones, and provides chondrogenic cells, to form new bones by endochondral ossification, during the repair of fractured or damaged bone (Hall, 1967;Ham, 1930;Oni et al, 1992).…”

Section: Introductionmentioning

confidence: 98%

Comparison of bone formation ingrafted periosteum harvested from tibia and calvaria

Fujii

Ueno

Kagawa

et al. 2006

Microscopy Res & Technique

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Periosteum covers the bone surface and displays the potential to initiate bone formation, after injury to the bone. Numerous studies have demonstrated that the periosteum plays major roles in the healing process after bone fracture. Some reports have described that in the healing of long bone fractures, the periosteum forms new bone by intramembranous and endochondral ossification. Other researchers insist that healing of defects in membrane bone shows bone formation by intramembranous ossification. However, previous studies have not been able to clarify differences in bone formation patterns. We hypothesized that differences in bone formation pattern are associated with the periosteal potential for cell differentiation. The present study grafted periosteum, harvested from the tibia and calvaria, into the suprahyoid muscle, with the aim of interrupting release of factors from bone matrix. Bone formation, after grafting periosteum, harvested from the tibia and calvaria, was examined histologically and radiographically. Grafted tibial periosteum formed a large area of new bone by intramembranous and endochondral ossification, while grafted calvarial periosteum displayed intramembranous ossification. Grafted tibial periosteum formed a larger area of bone than grafted calvarial periosteum. Patterns of cell differentiation thus differ between grafted periosteum, harvested from the tibia and calvaria.

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Remodeling of bone and bones: Effects of altered mechanical stress on the regeneration of transplanted bones

Storey

Feik

1986

Anat. Rec.

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We divided 116 rats weighing 50 gm into four groups with tails either left in situ or transplanted as follows: straight in situ: untreated controls; bent in situ: five caudal vertebrae (CV) in the loop; straight transplants: three CV skinned and transplanted autologously; and bent transplants: five CV skinned, bent to form a loop, and transplanted autologously. Tails were radiographed weekly up to 6 weeks and at 12 weeks, and microradiographic and histological studies were undertaken on selected specimens. At 12 weeks the bones in the apex of the loop of tails left in situ appeared bent with a straight-to-convex shaft on the outer side and a thicker, more concave one on the inner side. In the transplanted bent segments the bone shaft died and initially the reverse occurred: the outer shaft thickened and the inner resorbed completely. A new concave inner diaphysis then formed so that the bones in both instances were essentially similar in final shape. In the bent transplants the surviving osteogenic tissues regenerated and, adapting to the altered forces, formed a new bone shaft. This involved a change in the direction, amount, and nature of endochondral, periosteal, and regenerative growth and subsequent remodeling of bone. The results support previous observations that, within limits, the strain in the osteogenic envelope is an important factor in adaptation of bones to changing stress and that, where the envelope is deficient, the surviving tissues have the capacity to regenerate and repair defects in the bone so that it best resists the changing stresses applied to it.

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Electron Microscopy of Skeletal Aging

Cited by 8 publications

References 111 publications

Changes in the Microvasculature and Interstitium of Aged Human Mandibles and Maxillae¹

Changes in the Microvasculature and Interstitium of Aged Human Mandibles and Maxillae¹

Comparison of bone formation ingrafted periosteum harvested from tibia and calvaria

Remodeling of bone and bones: Effects of altered mechanical stress on the regeneration of transplanted bones

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Electron Microscopy of Skeletal Aging

Cited by 8 publications

References 111 publications

Changes in the Microvasculature and Interstitium of Aged Human Mandibles and Maxillae1

Changes in the Microvasculature and Interstitium of Aged Human Mandibles and Maxillae1

Comparison of bone formation ingrafted periosteum harvested from tibia and calvaria

Remodeling of bone and bones: Effects of altered mechanical stress on the regeneration of transplanted bones

Contact Info

Product

Resources

About

Changes in the Microvasculature and Interstitium of Aged Human Mandibles and Maxillae¹

Changes in the Microvasculature and Interstitium of Aged Human Mandibles and Maxillae¹