Electron Microscopy on the Pre- and Post-natal Development of the Pancreatic Acinar Cell of the Mouse

Koizumi, Haruo

doi:10.1620/tjem.78.58

Cited by 4 publications

(2 citation statements)

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“…3, 4), but they appear to be shrunk. If "dark" cells or dense core of zymogen granule has been noticed by several investigators (MUNCER, 1958;SJOSTRAND, 1961;KOIZUMI 1962). These previous studies dealt with fine structural changes in development of the pancreatic tissue and interpreted that the granules with "central condensation" are of immature type.…”

Section: Tendencymentioning

confidence: 91%

A Note on the “Dark” Cells of the Exocrine Pancreas

Ichikawa

1967

Arch. Histol. Jap., Arch. Histol. Jpn

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Section: Tendencymentioning

confidence: 91%

A Note on the “Dark” Cells of the Exocrine Pancreas

Ichikawa

1967

Arch. Histol. Jap., Arch. Histol. Jpn

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“…The morphogenetic events responsible for the development of the exocrine pancreas of rodents mainly occur during prenatal life (Koizumi, 1962;Kallman and Grobstein, 1964;Wessells and Cohen, 1967;Parsa, Marsh and Fitzgerald, 1969a,b;Pictet et aL 1972;Spooner, Cohen and Faubion 1977;Hisaoka, Haritake and Hashimoto, 1993;Taga, 1994). Thus, at birth the pancreas already exhibits differentiated acinar cells with the cytoplasm replete of zymogen granules.…”

mentioning

confidence: 99%

Morphometric and Allometric Study of the Mouse Exocrine Pancreas Growth During the Postnatal Life

Taga

Bispo

Bordin

et al. 1998

Okajimas Folia Anatomica Japonica

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Postnatal mouse pancreas growth was submitted to allometric analysis by the Wald nonparametric method, modified by Bartlett. The body and gland mass were obtained and the total cell number and the absolute compartmental volumes of acini, ducts and stroma were evaluated by morphometric methods. The allometric coefficients were calculated for the growths between the following parameters: a) pancreatic mass and body mass; b) acinar compartmental volume and body mass; c) ductal compartmental volume and body mass; d) stroma volume and body mass; e) total cell number and body mass; and f) acinar volume and stroma volume. The results of these analysis showed that the pancreatic mass, total cell number and stroma volume exhibited statistically significant allometric growths with a monophasic pattern and allometric coefficients of 1.56, 1.27 and 1.29, respectively, for the periods of 2 to 70, 2 to 28 and 2 to 70 days of age; while the growth of compartmental acinar volume in relation to body mass and compartmental stroma volume was biphasic. In the first case, the 1st phase occurred between 2 to 14 days (K = 1.09) and the 2nd phase between 14 to 70 days (K = 1.44) and in the second case, the 1st and 2nd phases occurred, respectively, between 2 to 28 days (K = 1.31) and 28 to 70 days (K = 0.79) of age. The growth of ductal volume in relation to body mass was also biphasic with a 1st phase between 2 to 14 days (K = 0.88) and a 2nd phase between 14 to 70 days (K = 1.07). These results permitted us to conclude that the growth of the mouse pancreas is allometrically associated with the growth of body mass.

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Perinatal changes in size of pancreatic acini in the rat with special reference to effects of fetal decapitation and fetal or neonatal oral administration of water or milk

et al. 1974

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Normally, the size of pancreatic acini is remarkably decreased after birth in the rat.Administration of water or milk on day 21 of gestation resulted in decreased acinar size a day later in intact fetuses and in fetuses decapitated immediately after administration of water or milk. The same treatments of premature newborn rats obtained by Caesarean section on day 22 of gestation induced similar effects a day later. On the other hand, in starved Caesarean newborn rats, there were no histologic changes in acini. In spontaneous newborn rats which were allowed to suckle maternal milk and then starved for one day, there was an increase in acinar size as compared with that of 2-day-old normal rats.These results suggest that the fetal pancreatic acini at least near term (on day 21 of gestation) can respond to some signals conveyed from digestive tracts which have responded to exogenous stimuli, that the brain during fetal days does not play any role in digestive tract-pancreatic acini interrelations in secretion of zymogen granules and that the neonatal decrease in acinar size is caused by the intake of maternal milk.

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Electron Microscopy on the Pre- and Post-natal Development of the Pancreatic Acinar Cell of the Mouse

Cited by 4 publications

References 1 publication

A Note on the “Dark” Cells of the Exocrine Pancreas

A Note on the “Dark” Cells of the Exocrine Pancreas

Morphometric and Allometric Study of the Mouse Exocrine Pancreas Growth During the Postnatal Life

Perinatal changes in size of pancreatic acini in the rat with special reference to effects of fetal decapitation and fetal or neonatal oral administration of water or milk

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