Electron microscopy study on the transport of lead oxide nanoparticles into brain structures following their subchronic intranasal administration in rats

Sutunkova, Marina P.; Minigalieva, Ilzira A.; Shelomencev, Ivan G.; Privalova, Larisa I.; Ryabova, Yuliya V.; Tazhigulova, Anastasiya Valeryevna; Amromin, Lev A.; Minigalieva, Regina F.; Sutunkova, Yuliya M.; Gurvich, Vladimir B.; Makoveeva, Eugenya V.; Toropova, Liubov V.

doi:10.1038/s41598-022-24018-7

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…The choice of dose in the study we analyzed was limited by the nanoparticle concentration in the suspension and the maximum allowable volume for intranasal instillation in rats. The design of the experiment was similar to that described elsewhere [ 47 ]. The sample size was decided based on the experience acquired in our previous studies and the assumed minimum number of rodents necessary to obtain trustworthy results.…”

Section: Methodsmentioning

confidence: 99%

Analysis of Experimental Data on Changes in Various Structures and Functions of the Rat Brain following Intranasal Administration of Fe2O3 Nanoparticles

Minigalieva

Ryabova

Shelomencev

et al. 2023

IJMS

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Particulate matter, including iron nanoparticles, is one of the constituents of ambient air pollution. We assessed the effect of iron oxide (Fe2O3) nanoparticles on the structure and function of the brain of rats. Electron microscopy showed Fe2O3 nanoparticles in the tissues of olfactory bulbs but not in the basal ganglia of the brain after their subchronic intranasal administration. We observed an increase in the number of axons with damaged myelin sheaths and in the proportion of pathologically altered mitochondria in the brains of the exposed animals against the background of almost stable blood parameters. We conclude that the central nervous system can be a target for toxicity of low-dose exposure to Fe2O3 nanoparticles.

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Section: Methodsmentioning

confidence: 99%

Analysis of Experimental Data on Changes in Various Structures and Functions of the Rat Brain following Intranasal Administration of Fe2O3 Nanoparticles

Minigalieva

Ryabova

Shelomencev

et al. 2023

IJMS

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“…We conducted an electron microscopy study of post-exposure ultrastructural pathological changes in the heart as described elsewhere [ 29 , 36 ].…”

Section: Methodsmentioning

confidence: 99%

On the Mechanisms of the Cardiotoxic Effect of Lead Oxide Nanoparticles

Minigaliyeva,

Klinova,

Sutunkova

et al. 2023

Cardiovasc Toxicol

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Lead compounds are one of the most common pollutants of the workplace air and the environment. In the occupational setting, the sources of their emission, including in nanoscale form, are various technological processes associated with lead smelting and handling of non-ferrous metals and their alloys, the production of copper and batteries. Both lead poisoning and lead exposure without obvious signs of poisoning have a detrimental effect on the cardiovascular system. The purpose of this research was to investigate the mechanisms of the cardiotoxic effect of lead oxide nanoparticles (PbO NPs). The toxicological experiment involved male albino rats subchronically exposed to PbO NPs (49.6 ± 16.0 nm in size) instilled intraperitoneally in a suspension. We then assessed post-exposure hematological and biochemical parameters of blood and urine, histological and ultrastructural changes in cardiomyocytes, and non-invasively recorded electrocardiograms and blood pressure parameters in the rodents. Myocardial contractility was studied on isolated preparations of cardiac muscles. We established that PbO NPs induced oxidative stress and damage to the ultrastructure of cardiomyocytes, and decreased efficiency of the contractile function of the myocardium and blood pressure parameters. We also revealed such specific changes in the organism of the exposed rats as anemia, hypoxia, and hypocalcemia. Graphical Abstract

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“…159 Sobolewski et al 160 showed that exposure to Fe 2 O 3 -NPs caused oxidative damage and neurotoxicity in the mouse brain. In addition to the above-mentioned NPs, NPs such as Ag-NPs, 161,162 PbO-NPs, 163 and ZnO-NPs 164 can cause damage to the nervous system to vary degrees. Taken together, NPs can be inhaled through the nose and mouth to cross the blood-brain barrier and cause neurological damage.…”

Section: Toxic Effects Of Nps On the Nervous Systemmentioning

confidence: 99%

Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

Xuan

Zhao

Skonieczna

et al. 2023

MedComm

114

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Nanoparticles (NPs) have become one of the most popular objects of scientific study during the past decades. However, despite wealth of study reports, still there is a gap, particularly in health toxicology studies, underlying mechanisms, and related evaluation models to deeply understanding the NPs risk effects. In this review, we first present a comprehensive landscape of the applications of NPs on health, especially addressing the role of NPs in medical diagnosis, therapy. Then, the toxicity of NPs on health systems is introduced. We describe in detail the effects of NPs on various systems, including respiratory, nervous, endocrine, immune, and reproductive systems, and the carcinogenicity of NPs. Furthermore, we unravels the underlying mechanisms of NPs including ROS accumulation, mitochondrial damage, inflammatory reaction, apoptosis, DNA damage, cell cycle, and epigenetic regulation. In addition, the classical study models such as cell lines and mice and the emerging models such as 3D organoids used for evaluating the toxicity or scientific study are both introduced. Overall, this review presents a critical summary and evaluation of the state of understanding of NPs, giving readers more better understanding of the NPs toxicology to remedy key gaps in knowledge and techniques.

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Electron microscopy study on the transport of lead oxide nanoparticles into brain structures following their subchronic intranasal administration in rats

Cited by 8 publications

References 24 publications

Analysis of Experimental Data on Changes in Various Structures and Functions of the Rat Brain following Intranasal Administration of Fe2O3 Nanoparticles

Analysis of Experimental Data on Changes in Various Structures and Functions of the Rat Brain following Intranasal Administration of Fe2O3 Nanoparticles

On the Mechanisms of the Cardiotoxic Effect of Lead Oxide Nanoparticles

Nanoparticles‐induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models

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