Electron Paramagnetic Resonance

Membrane proteins are essential for the survival of living organisms. They are involved in important biological functions including transportation of ions and molecules across the cell membrane and triggering the signaling pathways. They are targets of more than half of the modern medical drugs. Despite their biological significance, information about the structural dynamics of membrane proteins is lagging when compared to that of globular proteins. The major challenges with these systems are low expression yields and lack of appropriate solubilizing medium required for biophysical techniques. Electron paramagnetic resonance (EPR) spectroscopy coupled with site directed spin labeling (SDSL) is a rapidly growing powerful biophysical technique that can be used to obtain pertinent structural and dynamic information on membrane proteins. In this brief review, we will focus on the overview of the widely used EPR approaches and their emerging applications to answer structural and conformational dynamics related questions on important membrane protein systems.

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Electron Paramagnetic Resonance

Cited by 2 publications

References 137 publications

Symmetry breaking in single-crystal SrTiO₃ plates: EPR manifestations

Symmetry breaking in single-crystal SrTiO₃ plates: EPR manifestations

Probing Structural Dynamics of Membrane Proteins Using Electron Paramagnetic Resonance Spectroscopic Techniques

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Electron Paramagnetic Resonance

Cited by 2 publications

References 137 publications

Symmetry breaking in single-crystal SrTiO3 plates: EPR manifestations

Symmetry breaking in single-crystal SrTiO3 plates: EPR manifestations

Probing Structural Dynamics of Membrane Proteins Using Electron Paramagnetic Resonance Spectroscopic Techniques

Contact Info

Product

Resources

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Symmetry breaking in single-crystal SrTiO₃ plates: EPR manifestations

Symmetry breaking in single-crystal SrTiO₃ plates: EPR manifestations