Electron paramagnetic resonance (EPR) spectroscopy: Food, biomedical and pharmaceutical analysis

Iravani, Siavash; Soufi, Ghazaleh Jamalipour

doi:10.3233/bsi-200206

Cited by 9 publications

(3 citation statements)

References 69 publications

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“…Electron paramagnetic resonance (EPR) spectroscopy is an efficient and noninvasive spectroscopic method for analysing samples with unpaired electrons. It is used to quantify the types of radicals and analyse the antioxidative effects of substances [ 87 ]. EPR spectroscopy was applied for determining the potential and capacity of curcumin against free radicals (DPPH, nitric oxide radical (NO⋅), hydroxyl radical (HO∙) and superoxide anion radical (O 2 ) [ 88 , 89 ].…”

Section: Characterization Of Curcuminmentioning

confidence: 99%

Curcumin: Biological Activities and Modern Pharmaceutical Forms

et al. 2022

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Curcumin (1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione) is a natural lipophilic polyphenol that exhibits significant pharmacological effects in vitro and in vivo through various mechanisms of action. Numerous studies have identified and characterised the pharmacokinetic, pharmacodynamic, and clinical properties of curcumin. Curcumin has an anti-inflammatory, antioxidative, antinociceptive, antiparasitic, antimalarial effect, and it is used as a wound-healing agent. However, poor curcumin absorption in the small intestine, fast metabolism, and fast systemic elimination cause poor bioavailability of curcumin in human beings. In order to overcome these problems, a number of curcumin formulations have been developed. The aim of this paper is to provide an overview of recent research in biological and pharmaceutical aspects of curcumin, methods of sample preparation for its isolation (Soxhlet extraction, ultrasound extraction, pressurised fluid extraction, microwave extraction, enzyme-assisted aided extraction), analytical methods (FTIR, NIR, FT-Raman, UV-VIS, NMR, XRD, DSC, TLC, HPLC, HPTLC, LC-MS, UPLC/Q-TOF-MS) for identification and quantification of curcumin in different matrices, and different techniques for developing formulations. The optimal sample preparation and use of an appropriate analytical method will significantly improve the evaluation of formulations and the biological activity of curcumin.

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Section: Characterization Of Curcuminmentioning

confidence: 99%

Curcumin: Biological Activities and Modern Pharmaceutical Forms

et al. 2022

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“…In vitro EPR spectroscopy directly proves the presence of stable radical structures, such as semiquinone, nitroxide, etc., in water-soluble or lipo-soluble samples [19,20]. Most extracts of natural agents used in traditional medicine have stable radical structures and can be used strategically to develop protective creams, biomedicine, protection against UV-B or gamma radiation exposure, as cryoprotectants and as a sustainable resource for the biotechnology industry [21,22].…”

Section: Introductionmentioning

confidence: 99%

EPR spectroscopy investigation on the antioxidant efficacy of <i>Sambucus Nigra</i> L (dry flowers/blossom) extract

Petkova-Parlapanska,

Diankov,

Karsheva

2023

JCTM

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The present study aims to evaluate the antioxidant efficacy and the lipid peroxidation degree of Sambucus nigra L. (S. nigra) blossom extract after induction of biotic stress. Dry stained extracts of S. nigra flowers were analyzed by direct and indirect in vitro EPR spectroscopy. The antioxidant activity of the extract was assessed by DPPH analysis, and the inhibition of lipid peroxidation -by PBN-spin adduction, after UV-B and thermal stress. The direct EPR stable radical structures presence was established either in non-irradiated and UV-B irradiated samples. Furthermore, as before and after UV-B and thermal biotic stress, S. nigra showed well-expressed scavenging abilities and protective properties against reactive oxygen and nitrogen species such as superoxide radicals (•O 2 ̅ ), hydroxyl radicals (•OH), and reduced lipid peroxidation.

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“…Electron paramagnetic resonance (EPR) spectroscopy is a special analytical technology used to trace paramagnetic species through the measurement of the absorption of microwave radiation by unpaired electrons in a magnetic field. , With its advantages of excellent sensitivity and noninvasiveness for both solid and liquid samples, EPR spectroscopy has been applied in food, biomedical, and materials research. For instance, with its ability to evaluate free radicals, EPR spectroscopy has been set as a primary tool to identify irradiated foods in 1/3 of the current standards of the European Union .…”

Section: Introductionmentioning

confidence: 99%

Fast Screening of Coal Fly Ash with Potential for Rare Earth Element Recovery by Electron Paramagnetic Resonance Spectroscopy

Liu

Han

et al. 2021

Environ. Sci. Technol.

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Rare earth elements (REYs) are in increasing global demand, but their mining is costly and environmentally destructive. Coal fly ash (CFA) is a promising alternative source of REYs, but it is necessary to identify CFA with sufficiently high REY concentrations. This study proposes the use of electron paramagnetic resonance (EPR) spectroscopy as part of a simple method to identify CFAs with adequate REY concentrations. The EPR spectra of CFA samples taken from 186 Chinese commercial coal-fired power plants were analyzed. The results suggest that CFAs without evident 6-fold resonances are worth recycling (REY concentrations of 416 ± 108 mg/kg), while those with conspicuous 6-fold resonances are not worth recycling (REY concentrations of 55 ± 26 mg/kg). This is probably due to isomorphic substitution of Ca(II) for Mn(II) and REY(III), resulting in low concentrations of Mn(II) and REY(III) in Ca-rich CFAs. This EPR evaluation method does not require specialized sample preparation, professional skills, or secondary data analysis and has potential global significance in the fast screening of CFAs with REY-recycling potential.

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Electron paramagnetic resonance (EPR) spectroscopy: Food, biomedical and pharmaceutical analysis

Cited by 9 publications

References 69 publications

Curcumin: Biological Activities and Modern Pharmaceutical Forms

Curcumin: Biological Activities and Modern Pharmaceutical Forms

EPR spectroscopy investigation on the antioxidant efficacy of <i>Sambucus Nigra</i> L (dry flowers/blossom) extract

Fast Screening of Coal Fly Ash with Potential for Rare Earth Element Recovery by Electron Paramagnetic Resonance Spectroscopy

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