Electron pin resonane of chromanoxy free radicals from α-, ζ2-, β-, γ-, δ-tocopherol and tocol

Boguth, W.; Niemann, H.

doi:10.1016/0005-2760(71)90082-8

Cited by 63 publications

(12 citation statements)

References 15 publications

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“…The characteristic spectral splitting factor, g ‐value, of the radical is g = 2.0044 (shown by an arrow). These data are consistent with reports published in the literature 10, 14, 15…”

Section: Resultssupporting

confidence: 94%

Effects of packaging environments on free radicals in γ‐irradiated UHMWPE resin powder blend with vitamin E

Ridley

Jahan

2008

J Biomedical Materials Res

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Ultra-high molecular weight polyethylene (UHMWPE) powder (GUR 1020) was blended with high concentration (20%) of vitamin E (alpha-Tocopherol (alpha-T)) for direct detection of alpha-T radicals in presence of PE radicals. Samples were gamma-irradiated in sealed packages filled with N(2), or in open air. Free radicals were measured in open air environment for 71 days using electron spin resonance (ESR) technique. When irradiated in air, both alpha-T and alpha-T-resin produced identical ESR signals characteristics of tochopheroxyl radicals (alpha-T-O(*)), suggesting that PE radicals are quenched by alpha-T. There was no indication of growth of oxygen-induced radicals (OIR) either. However, when alpha-T-resin was irradiated in N(2), presence of both PE and alpha-T radicals were evident in the ESR spectra. And, OIR were produced by the same samples when they were subsequently exposed to air (for 71 days). Oxidation data recorded 85 days after postirradiation aging in air using Fourier transform infra-red (FTIR) spectroscopy, however, did not show any measurable difference between samples irradiated in N(2) and air.

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“…The characteristic spectral splitting factor, g ‐value, of the radical is g = 2.0044 (shown by an arrow). These data are consistent with reports published in the literature 10, 14, 15…”

Section: Resultssupporting

confidence: 94%

Effects of packaging environments on free radicals in γ‐irradiated UHMWPE resin powder blend with vitamin E

Ridley

Jahan

2008

J Biomedical Materials Res

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“…The characteristic spectral splitting factor, g-value, of the radical is g  2.0044 (shown by an arrow). These data are consistent with the reports found in the literature [35,40,41].…”

Section: Esr Of Vitamin E-doped Uhmwpesupporting

confidence: 94%

ESR Insights into Macroradicals in UHMWPE

Jahan¹

2009

UHMWPE Biomaterials Handbook

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“…Other work has also shown an injury-induced decline in spinal vitamin E (Anderson et al, 1986) and reduced ascorbate (Pietronigra et al, 1983). The antioxidant depletion is likely to be a reflection of posttraumatic lipid peroxidative reactions as vitamin E is utilized to quench lipid peroxyl radicals (Boguth and Niemann, 1971;Pryor, 1976). Previous studies have indicated that microvascular lipid peroxidation may be largely responsible for the development of posttraumatic spinal cord ischemia (see Fig.…”

Section: Discussionmentioning

confidence: 92%

Correlation Between Attenuation of Posttraumatic Spinal Cord Ischemia and Preservation of Tissue Vitamin E by the 21-Aminosteroid U74006F: Evidence for anIn VivoAntioxidant Mechanism

Hall¹,

Yonkers²,

Horan³

et al. 1989

Journal of Neurotrauma

115

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In the present study, the ability of U74006F, the 21-aminosteroid inhibitor of lipid peroxidation, to attenuate posttraumatic spinal cord ischemia has been examined in cats following a moderately severe compression injury. Moreover, in an attempt to assess whether U74006F is affecting in vivo posttraumatic lipid peroxidation, the effect of the compound on injury-induced spinal tissue vitamin E depletion was also studied. Following an initial 10 min postinjury hyperperfusion (+45%), spinal cord blood flow (SCBF) returned to the preinjury level at 30 min before entering a phase of progressive hypoperfusion, which reached -42.0 +/- 4.5% by 4 h postinjury in the vehicle-treated animals. In animals that received 30 min postinjury U74006F i.v. doses of 1.0, 3.0, or 10 mg/kg (plus 0.5, 1.5, and 5.0 mg/kg maintenance doses at 2.5 h.), the SCBF decline was reduced to -23.1%, -22.9%, and -26.1%, respectively (p less than 0.05 vs. vehicle at all three doses). A 0.3 mg/kg dose did not reduce the posttraumatic fall in SCBF. In vehicle-treated cats, the vitamin E content of the injured cord segment was reduced by 78.9% at 4 h postinjury in comparison to cord samples from uninjured vehicle-treated cats. In contrast, the same doses of U74006F (1.0, 3.0, and 10 mg/kg) that attenuated posttraumatic ischemia also significantly reduced the depletion of cord vitamin E. The lowest U74006F dosage (0.3 mg/kg), which failed to affect posttraumatic ischemia development, also had no effect on spinal cord vitamin E content.(ABSTRACT TRUNCATED AT 250 WORDS)

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Electron pin resonane of chromanoxy free radicals from α-, ζ2-, β-, γ-, δ-tocopherol and tocol

Cited by 63 publications

References 15 publications

Effects of packaging environments on free radicals in γ‐irradiated UHMWPE resin powder blend with vitamin E

Effects of packaging environments on free radicals in γ‐irradiated UHMWPE resin powder blend with vitamin E

ESR Insights into Macroradicals in UHMWPE

Correlation Between Attenuation of Posttraumatic Spinal Cord Ischemia and Preservation of Tissue Vitamin E by the 21-Aminosteroid U74006F: Evidence for anIn VivoAntioxidant Mechanism

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