Electron spin resonance measurements of blood caeruloplasmin and iron transferrin levels in patients with non-Hodgkin's lymphoma

Foster, Margaret A.; Dawson, Audrey A.; Pockington, T.; Fell, Lydia

doi:10.1016/s0009-9260(77)80131-1

Cited by 17 publications

(2 citation statements)

References 4 publications

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“…No explanation can be given for the raised levels in the intermediate-activity group (Table II). The fall in iron transferrin noted in active Hodgkin's disease was not seen in CLL, whereas in the more closely related nonHodgkin's lymphoma cases there was no significant abnormality in their iron transferrin levels (Foster et al, 1977b).…”

Section: Discussionmentioning

confidence: 73%

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Electron spin resonance studies on caeruloplasmin and iron transferrin in patients with chronic lymphocytic leukaemia

Green¹,

Pocklington²,

Dawson³

et al. 1980

Br J Cancer

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Summary.-Whole-blood caeruloplasmin measured by electron spin resonance was studied in 41 patients with chronic lymphocytic leukaemia. The levels were above normal at all stages of the disease, rose with increasing clinical involvement, and were higher in progressive than inactive disease. Whole -blood iron transferrin levels were more variable, and were significantly raised only in patients with marrow failure.

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Section: Discussionmentioning

confidence: 73%

“…In the non-Hodgkin's lymphomas, abnormal iron, copper and caeruloplasmin levels have been found, but their clinical usefulness has yet to be proved (Foster et al, 1977b). Hypercupraemia has also been found in conditions other than the lymphoreticular disorders, e.g.…”

mentioning

confidence: 99%

Electron spin resonance studies on caeruloplasmin and iron transferrin in patients with chronic lymphocytic leukaemia

Green¹,

Pocklington²,

Dawson³

et al. 1980

Br J Cancer

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Electron spin resonance studies on properties of ceruloplasmin and transferrin in blood from normal human subjects and cancer patients

Horn

Friesen

Stephens

et al. 1979

Cancer

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The methodology of blood sample preparation and analysis has been examined to further evaluate the technique of electron spin resonance (ESR) for possible use in detecting cancer and in monitoring the progress of cancer therapy. Frozen whole blood and serum samples from 278 normal donors and 97 cancer patients were studied by ESR for signal intensity from Cu+' bound to ceruloplasmin (g factor = 2.05). The signal from this species (Cu+'-CP) in serum rose sharply during the first two hours of storage at room temperature after being drawn from the subject, and then reached a plateau. The average Cu+'-CP ESR signal intensity was significantly different for control groups of males, females not taking estrogen medication, and females taking estrogens. The mean ESR signal intensities of Cu+'-CP from cancer patients separated into the same groups as the control data were approximately twice as great as the mean control levels. Total serum copper levels were correlated with ESR intensities of Cut2-CP and indicated that the ratio of Cu+'/Cuf' in CP is higher in serum from cancer patients than from controls. diseases as compared with control samples. It was also shown that there was a reduction in signal level over the course of treatment with radiotherapy. Foster et aLs described experiments in which they recorded ESR signals with g-values of 2.049 and 4.2 from frozen human whole blood samples. In a comparison between samples from 26 control subjects and 63 cancer patients, these authors demonstrated that the mean ESR level, at g = 2.049 of the cancer patients was significantly higher.

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Serum beta 2 microglobulin and C-reactive protein in the monitoring of lymphomas findings in a multicenter study and experience in selected patients

Child

Spati

Illingworth

et al. 1980

Cancer

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Serum beta 2 microglobulin (P2m) and C-Reactive protein (C-RP) were measured in patients with Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL). In a vertical study of 215 patients with HD and 171 with NHL, the serum P2m was raised in 8% of stage I and I1 and 47% of stage I11 and IV active untreated HD; the corresponding frequencies for patients in "complete remission" (CR) off treatment were 4% and 18%. In active NHL, p2m was elevated in 23% of stage I and I1 disease and 60% of stage I11 and I V disease; the frequencies for CR were 10% and 21%. The serum C-RP levels afforded interesting comparison: values >20 mg/l were found in 31% of stage I and I1 and 53% of stage I11 and I V active untreated HD. The corresponding frequencies for the CR groups were 5% in both. In active NHL, C-RP was elevated in 23% of stage I and I1 and 40% of stage 111 and 1V: the frequencies for the CR groups were 7% and 2%. When histopathological grade rather than clinical stage was considered in NHL, a raised P2m was found in association with "unfavorable" histologies in 78% of all untreated patients and 100% of stage IV disease. The detailed investigation of smaller numbers of patients including extended longitudinal studies provided additional information: the serum e2m was found to be independent of changes in serum C-RP, acid glycoprotein (a,AGP), fibrinogen, and the erythrocyte sedimentation rate (ESR). It was elevated in advanced untreated disease and persistent elevation probably reflected resistant or partially responsive disease. Chemotherapy produced a reduction in serum P2m levels with each individual course of treatment; this change was either part of a continuing overall reduction to normal or was transient, producing a characteristic "zig-zag" pattern. Biochemical tests in relation to fixed time points have limitations. Longitudinal studies can probably provide crucial information in only a small number of patients who are already being closely monitored. Nevertheless, serum p2m and C-RP levels can furnish useful information of potential clinical value and prognostic significance.Cancer 45318-326, 1980.

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Electron spin resonance measurements of blood caeruloplasmin and iron transferrin levels in patients with non-Hodgkin's lymphoma

Cited by 17 publications

References 4 publications

Electron spin resonance studies on caeruloplasmin and iron transferrin in patients with chronic lymphocytic leukaemia

Electron spin resonance studies on caeruloplasmin and iron transferrin in patients with chronic lymphocytic leukaemia

Electron spin resonance studies on properties of ceruloplasmin and transferrin in blood from normal human subjects and cancer patients

Serum beta 2 microglobulin and C-reactive protein in the monitoring of lymphomas findings in a multicenter study and experience in selected patients

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