Electron spin resonance of caeruloplasmin and iron transferrin in blood of patients with various malignant diseases

Abstract

Summary.-Electron spin resonance studies have been made of caeruloplasmin and iron transferrin levels in whole blood of healthy controls and patients with a variety of malignant conditions receiving various forms of treatment.A small difference was found in caeruloplasmin level between normal males and females, although normal females receiving contraceptive steroids had an elevated level. No difference was found in iron transferrin level. Various conditions increased the caeruloplasmin and some also decreased the iron transferrin level in patients with malignant disease. These included surgery and the approach of a terminal phase of disease. Once allowance for these factors was made, the remaining small differences in Cu and Fe between patients with either squamous cell carcinoma or breast cancer and controls appeared to have no clinical significance.

Electron spin resonance studies on caeruloplasmin and iron transferrin in patients with chronic lymphocytic leukaemia

“…There was no correlation between either metalloprotein and the total white-cell count, platelet count, haemoglobin or packed-cell volume. There was no sex difference in CLL patients, although a slight difference has been shown between normal males and females (Pocklington & Foster, 1977).…”

“…(Markovitz et al, 1955) and in other malignancies (Fisher & Shifrine, 1978;Andrews, 1979). The significance of raised copper levels in malignancy has been debated (Pocklington & Foster, 1977).…”

Estimation of the Malignancy of Pleural Effusions by Electron Spin Resonance

“…plasma, and serum are iron transferrin with a signal This value was estimated from a receiver-operating of g Å 4.2 and the copper ceruloplasmin with a signal of g Å 2.049 (2,(4)(5)(6)(7)(8)(9)(10)(11)(12)14). In the pleural effusions, we also observed the signals with g Å 4.2 and 2.049.…”

“…nance (ESR) 1 method on blood (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). Some authors The peak-to-peak height was used as a measure of sighave reported that the patients with the malignant nal intensity, since the signal was confirmed to have diseases such as cancer and Hodgkin's disease had a constant line width and line shape in all the samples.…”

Electron Spin Resonance in Haematological Research

“…E.s.r. provides a very rapid method for the measurement ofiron transferrin and an extension of thc method can be used to provide an estimatc of the total plasma transfcrrin concentration (Pocklington et a / , 1977). E.s.r.…”